Ghrelin, an endogenous growth hormone secretagogue with diverse endocrine and nonendocrine effects

Bhatti, Sofie; Ham, Luc M. Van; Mol, Jan A.; Kooistra, Hans S.

doi:10.2460/ajvr.67.1.180

Cited by 6 publications

(4 citation statements)

References 170 publications

(147 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ghrelin is synthesized and released primarily by endocrine X/A cells in the stomach (Kojima et al, 1999;Bhatti et al, 2006) and plays an important role in the control of GH secretion. Kojima et al (1999) found that ghrelin specifically stimulated GH release, but did not affect other pituitary hormones.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Growth-promoting Effect of Tetrabasic Zinc Chloride is Associated with Elevated Concentration of Growth Hormone and Ghrelin

Zhang¹,

Guo²

2008

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

An experiment was conducted to investigate the mechanism for the effect of tetrabasic zinc chloride (TBZC) in enhancing growth performance of weanling piglets. Gut-brain peptides play an important role in the regulation of growth and appetite in animals. This study evaluated the effects of TBZC on blood concentrations of growth hormone (GH), ghrelin, insulin-like growth factor-I (IGF-I), cholecystokinin (CCK) and neuropeptide Y (NPY). Seventy-two weanling piglets (Landrace×Large White) with an initial body weight (BW) of 6.7±0.16 kg and aged 24±1 days were assigned to three dietary treatments: i) control diet without TBZC supplement, ii) the control diet supplemented with 2,000 mg Zn from TBZC/kg and iii) TBZC-supplemented diet pair-fed with respect to the control diet. Each treatment had six replications (pens) of four piglets. At the end of a 14-d experimental period, piglets were weighed and feed consumption was measured, and blood samples were collected for assays of GH, ghrelin, IGF-I, CCK and NPY concentrations. The inclusion of TBZC in the diet increased average daily gain (p<0.01), average daily feed intake (p<0.05), and feed conversion ratio (p<0.05). Pair-fed piglets had higher ADG, and lower FCR than (p<0.05) Control piglets. Supplementation of the diet with TBZC increased (p<0.05) serum GH and plasma ghrelin levels in weanling piglets, but did not affect (p>0.05) serum IGF-I and plasma NPY and CCK concentrations. Pair-fed piglets had lower (p<0.05) serum GH levels than TBZC-supplemented piglets, but did not (p>0.05) differ from Control piglets. These data indicated that TBZC elevated the concentration of ghrelin and GH. This observation may partly explain the beneficial effects of TBZC on growth performance of weanling piglets.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Circulating ghrelin, the endogenous ligand of GH secretagogues-receptor (GHS-R), is synthesized primarily in the stomach in mammals (Bhatti et al, 2006). Ghrelin acts on the GHS-R, increasing intracellular Ca 2+ levels via inositol 1,4,5-trisphosphate (IP3) to stimulate GH release (Kojima and Kangawa, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Growth-promoting Effect of Tetrabasic Zinc Chloride is Associated with Elevated Concentration of Growth Hormone and Ghrelin

Zhang¹,

Guo²

2008

Asian Australas. J. Anim. Sci

View full text Add to dashboard Cite

show abstract

“…Ghrelin acts through a receptor separate from the GHRH receptor, called the GH secretagogue receptor (GHS-R), or ghrelin receptor. In humans, GH release after ghrelin administration is more pronounced than after GHRH administration, and the effect is not absolutely specific, because ghrelin also increases the secretion of prolactin, ACTH, and cortisol (Bhatti et al, 2006a). Interestingly, the GHS-R was identified several years before the discovery of its natural ligand ghrelin and was therefore also called "orphan" GHS-R.…”

Section: Regulation Of Growth Hormone Secretion From the Pituitary Glandmentioning

confidence: 99%

“…;Bhatti et al, 2006a;Mol and Meij, 2008; Box 2-1). Simplified, schematic representation of the hypothalamus-pituitary-growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis.…”

mentioning

confidence: 99%