Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

Kluge, Michael; Schüssler, P.; Bleninger, Philipp; Kleyer, Sara; Uhr, Manfred; Weikel, J.; Yassouridis, Alexander; Zuber, Verena; Steiger, Axel

doi:10.1016/j.psyneuen.2008.01.008

Cited by 48 publications

(28 citation statements)

References 44 publications

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“…Thus, we have shown that the appetite-related hormone ghrelin was associated with temperature variability, which may be linked to its circadian behavior. Ghrelin spikes occur at times coincident with classical meal times, showing both circadian and ultradian rhythms (Drazen et al, 2006; Kluge et al, 2008; Motivala et al, 2009). Further, the inverse correlation found between ghrelin, the rhythm amplitude, and the percentage of rhythmicity (PR), the latter two being indicators of circadian robustness, seems to be consistent with previous reports showing an association between increased ghrelin and lack of sleep (Motivala et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Differences in Daily Rhythms of Wrist Temperature Between Obese and Normal-Weight Women: Associations With Metabolic Syndrome Features

Corbalán-Tutau¹,

Madrid²,

Ordovás³

et al. 2011

Chronobiology International

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The circadian rhythm of core body temperature is associated with widespread physiological effects. However, studies with other more practical temperature measures, such as wrist (WT) and proximal temperatures, are still scarce. The aim of this study was to investigate whether obesity is associated with differences in mean WT values or in its daily rhythmicity patterns. Daily patterns of cortisol, melatonin, and different metabolic syndrome (MetS) features were also analyzed in an attempt to clarify the potential association between chronodisruption and MetS. The study was conducted on 20 normal-weight women (age: 38 ± 11 yrs and BMI: 22 ± 2.6 kg/m2) and 50 obese women (age: 42 ± 10 yrs and BMI: 33.5 ± 3.2 kg/m2) (mean ± SEM). Skin temperature was measured over a 3-day period every 10 min with the “Thermochron iButton.” Rhythmic parameters were obtained using an integrated package for time-series analysis, “Circadianware.” Obese women displayed significantly lower mean WT (34.1°C ± 0.3°C) with a more flattened 24-h pattern, a lower-quality rhythm, and a higher intraday variability (IV). Particularly interesting were the marked differences between obese and normal-weight women in the secondary WT peak in the postprandial period (second-harmonic power [P2]), considered as a marker of chronodisruption and of metabolic alterations. WT rhythmicity characteristics were related to MetS features, obesity-related proteins, and circadian markers, such as melatonin. In summary, obese women displayed a lower-quality WT daily rhythm with a more flattened pattern (particularly in the postprandial period) and increased IV, which suggests a greater fragmentation of the rest/activity rhythm compared to normal-weight women. These 24-h changes were associated with higher MetS risk.

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Section: Discussionmentioning

confidence: 99%

Differences in Daily Rhythms of Wrist Temperature Between Obese and Normal-Weight Women: Associations With Metabolic Syndrome Features

Corbalán-Tutau¹,

Madrid²,

Ordovás³

et al. 2011

Chronobiology International

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“…This might be of relevance, as both ghrelin plasma levels and some effects of ghrelin, e.g. on sleep, exhibit sex differences [29,31,32] . Furthermore, different measurement methods may also account for the different results, at least in part.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin Plasma Levels Are Not Altered in Major Depression

Kluge¹,

Schüssler²,

Schmid³

et al. 2009

Neuropsychobiology

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Background: In patients with major depression, the function of most endocrine axes is altered compared to healthy subjects. The orexigenic hormone ghrelin, which shows higher plasma levels in females than males, interacts with several of these endocrine axes. In addition, ghrelin levels in depressed patients decrease with psychopathological improvement. Therefore, we hypothesized that ghrelin levels in patients with major depression would be higher than in healthy subjects. Methods: Nocturnal (20:00–07:00 h) secretion patterns of ghrelin in 20 patients with major depression [11 females, age 39.4 ± 10.2 years (mean ± standard deviation); 9 males, age 38.3 ± 10.4 years] with a total score on the Hamilton Depression Rating Scale, 21-item version, of 24.8 ± 5.2 and 20 healthy subjects [11 females, age 38.7 ± 10.8 years; 9 males, age 39.1 ± 11.2 years] were determined following an adaptation night. Results: Ghrelin plasma levels of depressed patients and matched healthy subjects did not differ at any point in time when stratified for sex. Accordingly, the area under the curve was comparable: depressed females, 423.3 ± 103.4; healthy females, 398.0 ± 94.6; depressed males, 266.3 ± 56.9, and healthy males, 228.4 ± 41.3. Conclusion: This is the first comparison of ghrelin secretion patterns in patients with major depression and healthy controls. Surprisingly, no relevant differences were ascertained between the two groups.

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“…cannula and a tubic extension. Furthermore, sleep EEGs were conducted between 2300 and 0700 h. These data have been presented elsewhere (26,27). Substances (e.g.…”

Section: Methodsmentioning

confidence: 99%

Ghrelin affects the hypothalamus–pituitary–thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma

Kluge

Riedl

Uhr

et al. 2010

European Journal of Endocrinology

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Objective: Ghrelin promotes a positive energy balance, e.g. by increasing food intake. Stimulation of the activity of the hypothalamus-pituitary-thyroid (HPT) axis promotes a negative energy balance, e.g. by increasing energy expenditure. We therefore hypothesized that ghrelin suppresses the HPT axis in humans, counteracting its energy-saving effect. Design and methods: In this single-blind, randomized, cross-over study, we determined secretion patterns of free triiodothyronine (fT 3 ), free thyroxine (fT 4 ), TSH, and thyroid-binding globulin (TBG) between 2000 and 0700 h in 20 healthy adults (10 males and 10 females, 25.3G2.7 years) receiving 50 mg ghrelin or placebo at 2200, 2300, 0000, and 0100 h. Results: FT 4 plasma levels were significantly higher after ghrelin administration than after placebo administration from 0000 h until 0620 h except for the time points at 0100, 0520, and 0600 h. TSH plasma levels were significantly lower from 0200 until the end of the study at 0700 h except for the time points at 0540, 0600, and 0620 h. The relative increase of fT 4 (area under the curve (AUC) 0130-0700 h (ng/dl!min): placebo: 1.31G0.03; ghrelin: 1.39G0.03; PZ0.001) was much weaker than the relative decrease of TSH (AUC 0130-0700 h (mIU/ml!min): placebo: 1.74G0.12; ghrelin: 1.32G0.12; PZ0.007). FT 3 and TBG were not affected. Conclusions: This is the first study to report that ghrelin affects the HPT axis in humans. The early fT 4 increase was possibly induced by direct ghrelin action on the thyroid where ghrelin receptors have been identified. The TSH decrease might have been caused by ghrelin-mediated inhibition at hypothalamic level by feedback inhibition through fT 4 , or both.

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Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

Cited by 48 publications

References 44 publications

Differences in Daily Rhythms of Wrist Temperature Between Obese and Normal-Weight Women: Associations With Metabolic Syndrome Features

Differences in Daily Rhythms of Wrist Temperature Between Obese and Normal-Weight Women: Associations With Metabolic Syndrome Features

Ghrelin Plasma Levels Are Not Altered in Major Depression

Ghrelin affects the hypothalamus–pituitary–thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma

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