Ghrelin Activates Behavior of Neonatal Chicks in a Short Period of Post-Intracerebroventricular Injection

Saito, Ei Suke; Takagi, Tohru; Nakanishi, Tomonori; Sashihara, Kouichi; Furuse, Mitsuhiro

doi:10.1080/09712119.2002.9706376

Cited by 15 publications

(4 citation statements)

References 17 publications

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“…The effect was not altered by capsaicin treatment which indicate that peripheral des-acyl ghrelin may induce anorexigenic function by direct activation of brain receptor by crossing the blood-brain barrier but not by the activation of vagal afferent pathways (Chen et al, 2005). Although little is known about des-ghrelin in birds, Saito et al (2002) reported that icv injection of des-ghrelin did not change feed intake in neonatal chicks. However, in the present study, we reported that activity of ghrelin was restricted after peripheral blocking of CRH receptors in 7-day-old chickens.…”

Section: Discussionmentioning

confidence: 93%

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Ocłoń¹,

Pietras²

2011

J. Anim. Feed Sci.

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It is known that centrally injected ghrelin is an anorexigenic peptide in chicken. Its activity is not mediated by NPY/AgRP -producing neurons but through the corticosterone releasing hormone (CRH) -expressing neurons in hypothalamus which activate the hypothalamo-pituitary-adrenal (HPA) axis inducing an increase in plasma corticosterone levels. However, controversial results of peripheral ghrelin effect on appetite have been reported. Thus, the influence of intraperitonealinjected ghrelin on the activity of the HPA axis in Cobb broiler chickens was examined. In addition, the effect of glucocorticoids antagonist (RU486) on the ghrelin activity was also investigated. The intraperitoneal co-injection of CRH-receptor antagonist, astressin, partially attenuated ghrelininduced anorexia and corticosterone release. Co-administration of RU486 significantly enhanced the inhibitory effect of ghrelin on feed intake in 7-day-old broiler chickens. These results indicate that the peripheral ghrelin -induced anorexia is caused by the stimulation of HPA axis in chickens.

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Section: Discussionmentioning

confidence: 93%

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Ocłoń¹,

Pietras²

2011

J. Anim. Feed Sci.

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“…ICV-injected ghrelin induces several behavioral changes such as vocalization and hyper activity in neonatal chicks (Saito et al, 2002b). These behaviors are also induced by ICV injection of corticotropin-releasing hormone (CRH) (Zhang et al, 2001a), and CRH itself is regarded as an anorexigenic peptide in chicks (Furuse et al, 1997b).…”

Section: Peripheral Peptidergic Hormonesmentioning

confidence: 99%

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

Tachibana

Tsutsui

2016

Front. Neurosci.

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Feeding is an essential behavior for animals to sustain their lives. Over the past several decades, many neuropeptides that regulate feeding behavior have been identified in vertebrates. These neuropeptides are called “feeding regulatory neuropeptides.” There have been numerous studies on the role of feeding regulatory neuropeptides in vertebrates including birds. Some feeding regulatory neuropeptides show different effects on feeding behavior between birds and other vertebrates, particularly mammals. The difference is marked with orexigenic neuropeptides. For example, melanin-concentrating hormone, orexin, and motilin, which are regarded as orexigenic neuropeptides in mammals, have no effect on feeding behavior in birds. Furthermore, ghrelin and growth hormone-releasing hormone, which are also known as orexigenic neuropeptides in mammals, suppress feeding behavior in birds. Thus, it is likely that the feeding regulatory mechanism has changed during the evolution of vertebrates. This review summarizes the recent knowledge of peptidergic feeding regulatory factors in birds and discusses the difference in their action between birds and other vertebrates.

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“…Numerous studies with birds have now clearly shown that ghrelin administered icv inhibits food intake in a dose-dependent manner under both fed and fasted conditions [ 2 – 5 , 17 , 29 , 43 , 44 ]. In contrast, central administration of des-acyl ghrelin had no effect on food intake in neonatal chicks [ 45 ]. However, peripheral administration of ghrelin produced some conflicting findings with respect to its effects on food intake [ 18 , 29 , 46 ].…”

Section: Physiological Actions Of Proghrelin-derived Peptidesmentioning

confidence: 99%

“…As part of the studies of the various physiological actions of ghrelin in birds, it has been noted that this peptide also has important impacts on behavior. For example, ghrelin has been reported to induce sleep-like behavior in a dose-dependent manner when administered centrally to fed or fasted neonatal chicks suggesting that this behavior may be related to its inhibitory effect on food intake [ 45 , 61 ]. However, the sleep-like behavior was preceded by a short period (less than 30 minutes) of hyperactivity and increased vocalization [ 61 ].…”

Section: Physiological Actions Of Proghrelin-derived Peptidesmentioning

confidence: 99%

The Avian Proghrelin System

Richards

McMurtry

2010

International Journal of Peptides

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To understand how the proghrelin system functions in regulating growth hormone release and food intake as well as defining its pleiotropic roles in such diverse physiological processes as energy homeostasis, gastrointestinal tract function and reproduction require detailed knowledge of the structure and function of the components that comprise this system. These include the preproghrelin gene that encodes the proghrelin precursor protein from which two peptide hormones, ghrelin and obestatin, are derived and the cognate receptors that bind proghrelin-derived peptides to mediate their physiological actions in different tissues. Also key to the functioning of this system is the posttranslational processing of the proghrelin precursor protein and the individual peptides derived from it. While this system has been intensively studied in a variety of animal species and humans over the last decade, there has been considerably less investigation of the avian proghrelin system which exhibits some unique differences compared to mammals. This review summarizes what is currently known about the proghrelin system in birds and offers new insights into the nature and function of this important endocrine system. Such information facilitates cross-species comparisons and contributes to our understanding of the evolution of the proghrelin system.

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Ghrelin Activates Behavior of Neonatal Chicks in a Short Period of Post-Intracerebroventricular Injection

Abstract: Saito, E., Takagi, T., Nakanishi, T., Sashihara, K. and Furuse, M. 2002. Ghrelin activates behavior of neonatal chicks in a short period of postintracerebroventricular injection. J . Appl. Anim. Res., 22: 33-41. Ghrelin, a novel growth hormone (GH)-

Cited by 15 publications

References 17 publications

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken

Neuropeptide Control of Feeding Behavior in Birds and Its Difference with Mammals

The Avian Proghrelin System

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