Ghrelin

Müller, Timo; Nogueiras, Rubén; Andermann, Mark L.; Andrews, Zane B.; Anker, Stefan D.; Argente, Jesús; Batterham, Rachel L.; Benoit, Stephen C.; Bowers, Cyril Y.; Broglio, Fabio; Casanueva, Felipe F.; D’Alessio, David A.; Depoortere, Inge; Geliebter, Allan; Ghigo, Ezio; Cole, Philip A.; Cowley, Michael A.; Cummings, David E.; Dagher, Alain; Diano, Sabrina; Dickson, Suzanne L.; Diéguez, Carlos; Granata, Riccarda; Grill, Harvey J.; Grove, Kevin L.; Habegger, Kirk M.; Heppner, Kristy M.; Heiman, Mark L.; Holsen, Laura M.; Holst, Birgitte; Inui, Akio; Jansson, J-O; Kirchner, Henriette; Korbonits, Márta; Laferrère, Blandine; Leroux, Christine; López, Miguel; Morin, Sophie; Nakazato, Michiko; Nass, Ralf; Pérez-Tilve, Diego; Pfluger, Paul T.; Schwartz, Thue W.; Seeley, Randy J.; Sleeman, Mark W.; Sun, Yuxiang; Sussel, Lori; Tong, Jenny; Thorner, Michael O.; Lely, Aart Jan van der; Ploeg, Lex H.T. Van der; Zigman, Jeffrey M.; Kojima, Masayasu; Kangawa, Kenji; Smith, Roy G.; Horváth, Tamas L.; Tschöp, Matthias H.

doi:10.1016/j.molmet.2015.03.005

Cited by 845 publications

(670 citation statements)

References 378 publications

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“…This orexigenic effect is mediated by changes in fatty acid metabolism and other parameters related to fatty acid-sensing systems that basically reverse those elicited by raised levels of LCFA (Ló pez et al 2008, Sangiao-Alvarellos et al 2010, Martins et al 2013, Gao et al 2013, Stark et al 2015. Besides the role of GHRL in food intake regulation, this hormone has been also involved in the control of glucose and lipid homeostasis and metabolism (Sangiao-Alvarellos et al 2010, Ratner et al 2015 and modulation of hormone release (Carreira et al 2013), among others (Sato et al 2014, Müller et al 2015. GHRL has been also identified in a number of fish species, including rainbow trout (Oncorhynchus mykiss), Japanese eel (Anguilla japonica), sea bass (Dicentrarchus labrax), Atlantic salmon (Salmo salar), zebrafish (Danio rerio), goldfish (Carassius auratus), tilapia (Oreochromis mossambicus) and channel catfish (Ictalurus punctatus) (Kaiya et al 2008, Kang et al 2011.…”

Section: Introductionmentioning

confidence: 99%

Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout

Velasco¹,

Librán-Pérez²,

Otero-Rodiño³

et al. 2015

Journal of Endocrinology

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There is no information available on fish as far as the possible effects of ghrelin on hypothalamic fatty acid metabolism and the response of fatty acid-sensing systems, which are involved in the control of food intake. Therefore, we assessed in rainbow trout the response of food intake, hypothalamic fatty acid-sensing mechanisms and expression of neuropeptides involved in the control of food intake to the central treatment of ghrelin in the presence or absence of a long-chain fatty acid such as oleate. We observed that the orexigenic actions of ghrelin in rainbow trout are associated with changes in fatty acid metabolism in the hypothalamus and an inhibition of fatty acid-sensing mechanisms, which ultimately lead to changes in the expression of anorexigenic and orexigenic peptides resulting in increased orexigenic potential and food intake. Moreover, the response to increased levels of oleate of hypothalamic fatty acid-sensing systems (activation), expression of neuropeptides (enhanced anorexigenic potential) and food intake (decrease) were counteracted by the simultaneous treatment with ghrelin. These changes provide evidence for the first time in fish of a possible modulatory role of ghrelin on the metabolic regulation by fatty acid of food intake occurring in the hypothalamus.

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Section: Introductionmentioning

confidence: 99%

Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout

Velasco¹,

Librán-Pérez²,

Otero-Rodiño³

et al. 2015

Journal of Endocrinology

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“…WC was determined by measuring the narrowest point between the costal margin and iliac crest at the end of a normal expiration. BMI was calculated as weight (kg)/height (m) 2 . After an 8-12 hour overnight fast, venipuncture was performed between 8:00 a.m. and 9:00 a.m. and blood samples were collected into plain tubes.…”

Section: Clinical Biochemical and Hormonal Measurementsmentioning

confidence: 99%

“…Ghrelin has well-documented systemic actions including stimulation of gastrointestinal system motility; gastric acid secretion; regulation of sleep, taste sensation, and reward-seeking behavior; modulation of glucose metabolism; suppression of brown fat thermogenesis; regulation of stress and anxiety; prevention of muscle atrophy; and improvement of cardiovascular functions such as vasodilatation and cardiac contractility (2). Ghrelin was implicated in several processes of cancer progression including cell proliferation, cell migration and invasion, angiogenesis, and apoptosis, probably via an autocrine/paracrine mechanism.…”

Section: Introductionmentioning

confidence: 99%

Serum ghrelin levels in papillary thyroid carcinoma

Uçan

Şahi̇n

Kızılgül

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Ghrelin plays a role in several processes of cancer progression, and numerous cancer types express ghrelin and its receptor. We aimed to investigate serum levels of ghrelin in patients with papillary thyroid carcinoma (PTC) and its association with the prognostic factors in PTC. Materials and methods: We enrolled 54 patients with thyroid cancer (7 male, 47 female) and 24 healthy controls (6 male, 18 female) in the study. We compared demographic, anthropometric, and biochemical data, and serum ghrelin levels between the groups. Serum ghrelin levels were measured using as enzyme-linked immunosorbent assay. Results: Ghrelin levels were similar between the groups, but plasma ghrelin levels were significantly higher in tumors larger than 1 cm diameter compared with papillary microcarcinomas. Serum ghrelin levels also correlated with tumor size (r = 0.499; p < 0.001). Body mass index, thyroid-stimulating hormone, and HOMA-IR levels were similar between the groups. There were no statistically significant differences regarding average age and other prognostic parameters including lymph node invasion, capsule invasion, multifocality and surgical border invasion between patients with microcarcinoma and tumors larger than 1 cm. Conclusion: In our study, no significant difference in serum ghrelin levels was determined between patients with papillary thyroid cancer and healthy controls however, serum ghrelin levels were higher in tumors larger than 1 cm compared to in those with thyroid papillary microcarcinoma. Arch Endocrinol Metab. 2017;61(5):464-9

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“…In this sense, the development of adipogenesis under non-pathological conditions corresponds with a high food consumption and loss of physical activity. Under this concept, ghrelin an orexigenic peptide have a fundamental role, acting on the brain to regulate food intake, body weight, adiposity and glucose metabolism (12). Furthermore, lipoprotein lipase (LPL) is an enzyme with numerous physiological activities, which mainly include the regulation of fatty acid supply to various tissues for either storage or oxidation (13).…”

Section: Introductionmentioning

confidence: 99%

Changes in body composition and mRNA expression of ghrelin and lipoprotein lipase in rats treated with leuprolide acetate, a GnRH agonist

et al. 2017

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Abstract. Leuprolide acetate (LA), a gonadotropin-releasing hormone (GnRH) agonist, was identified to cause changes in body weight in experimental and clinical trials; however, to date, the effect of LA on the body composition has not been properly assessed. The aim of the present study was to evaluate the long-term effect of LA administration on body composition and the mRNA expression of ghrelin and lipoprotein lipase (LPL) in rats. Ovariectomized (OVX), ovariectomized and LA-treated (OVX+LA), non-ovariectomized (CTRL) and non-ovariectomized but LA-treated (LA) rats were used. LA treatment was performed by intramuscular injection at 5 µg/kg every 72 h over 120 days. Analysis of body composition and mRNA expression of ghrelin and lipoprotein lipase were performed. The results indicated significant changes in body composition after treatment; in the OVX, LA, OVX+LA and CTRL group, the body weight was increased by 216.1, 183.7, 175.4 and 150.1%, respectively, compared with baseline. The fat mass in the LA group was 14% higher than that in the CTRL group, while that in the OVX group was 19% higher than that in the OVX+LA, and the fat-free mass was similar between the LA and CTRL as well as the OVX and OVX+LA groups. Following 120 days of treatment, the mRNA expression of ghrelin and LPL in the LA group was ~20% higher than that in the CTRL group, while that in the OVX+LA was downregulated in comparison with that in the OVX group. The results of the present study confirmed changes in body composition and mRNA expression of ghrelin and LPL caused by long-term administration of LA. LA may contribute to regulate food consumption and exert control over adipogenesis.

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Ghrelin

Cited by 845 publications

References 378 publications

Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout

Ghrelin modulates hypothalamic fatty acid-sensing and control of food intake in rainbow trout

Serum ghrelin levels in papillary thyroid carcinoma

Changes in body composition and mRNA expression of ghrelin and lipoprotein lipase in rats treated with leuprolide acetate, a GnRH agonist

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