Although the emotional consequences of social rejection are well-documented, less is known about the emotional antecedents of social rejection decisions. In a set of two preregistered studies, the present research examines the association of anxiety symptoms, depressive symptoms, general distress, and self-esteem with attitudes toward engaging in different types of rejection in the contexts of friendship and romantic relationships. Across both studies, participants experiencing higher levels of general distress and lower levels of self-esteem indicated that engaging in social rejection would be more difficult and would lead to higher levels of negative emotion. However, participants did not differ in their reported willingness to engage in social rejection based on depressive symptoms, anxiety symptoms, or self-esteem, nor did these markers of negative affect relate to the number of romantic relationships they had ended. Additionally, symptoms did not differentiate between likelihood of explicit rejection or passive rejection (ghosting); participants reported being unwilling to ghost in romantic relationships in both studies. Taken together, the two studies suggest that psychological distress may not result in decreased willingness to reject a friend or partner, but may make the idea of doing so seem more difficult.