Ghost cell odontogenic carcinoma: A case report

Panprasit, Wariya; Lappanakokiat, Napas; Kunmongkolwut, Sumana; Phattarataratip, Ekarat; Rochchanavibhata, Sunisa; Sinpitaksakul, Phonkit; Cholitgul, Wichitsak

doi:10.5624/isd.20200296

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…The 5-year survival rate for GCOC is about 73% and distant metastases are rare. [5] The recommended treatment for GCOC is extensive surgical excision with clean margins. [6,7] To date, no research has been able to determine whether immunotherapy and chemotherapy are effective in treating inoperable ghost cell odontogenic carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Ghost cell odontogenic carcinoma: A rare case report and review of literature

Xia,

Song,

Zhang

et al. 2023

Medicine

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Rationale: Ghost cell odontogenic carcinoma is a rare malignant odontogenic carcinoma characterized by the presence of ghost cells. It has a nonspecific clinical and radiographic presentation and can be locally destructive and invasive, sometimes with distant metastases. However, no effective systemic therapy is currently recommended for such patients. Patient concerns: The patient has been unable to undergo surgery or radiotherapy again. Therefore, he was referred to our department for a more aggressive, multimodal systematic treatment program. Diagnoses: The histopathological examination was morphologically suggestive of ghost cell odontogenic carcinomas. Interventions: We report a case of locally invasive primary inoperable odontogenic shadow cell carcinoma in a 31-year-old Chinese man who achieved treatment with Toripalimab and chemotherapy, followed by Toripalimab maintenance therapy after 6 cycles. Outcomes: He achieved partial remission after treatment. The quality of life significantly improved after treatment. There were no grade 3/4 treatment-related adverse events during treatment. Lessons: This case presented that Toripalimab and chemotherapy may be a safe and effective systemic therapy for ghost cell odontogenic carcinoma.

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Section: Introductionmentioning

confidence: 99%

Ghost cell odontogenic carcinoma: A rare case report and review of literature

Xia,

Song,

Zhang

et al. 2023

Medicine

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“…Other treatment options of GCOC include conservative surgery, radiation therapy, or chemotherapy ( 9 , 10 ). The effects of radiation therapy or chemotherapy on GCOC remain uncertain because of the rarity of the tumor, with a prevalence of 0.37% of all odontogenic tumors in the oral cavity ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome

Kim,

Lee,

Kim

et al. 2023

Front. Vet. Sci.

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A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right mandibular canine to the fourth premolar, along with horizontal bone loss and dorsal displacement of the right mandibular first and second premolars. Skull cone beam computed tomography revealed osteolysis at the level of the right mandibular canine and fourth premolar. A destructive bone lesion was observed in the apical area of the right mandibular canine, with mass invasion of the interradicular bone of the right mandibular first molar near the mandibular canal. Consequently, unilateral total mandibulectomy and skin flap surgery were performed. Histopathological examination revealed poorly demarcated and infiltrative neoplastic epithelial cells that formed small islands and trabeculae. Neoplastic cells exhibited the malignant features of cytological atypia and high mitotic activity. Furthermore, the neoplastic epithelial cells frequently showed ghost cell changes and were diagnosed as ghost cell odontogenic carcinoma (GCOC). The dog was followed up for 1 year, during which no severe complications or local recurrence was observed, except for slight mandibular drift, tongue protrusion, and drooling. This case report describes the clinical features, diagnostic imaging, and histologic features of an unreported GCOC in a dog and the favorable outcome following surgical resection.

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