Ghost cell characterization in calcifying odontogenic cysts and dentinogenic ghost cell tumors: An immunohistochemical study

Urs, Aadithya B; Jot, Kiran; Kumar, Manoj

doi:10.1016/j.job.2020.10.002

Cited by 7 publications

(9 citation statements)

References 16 publications

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“…This feature was also present in cases with concomitant CK14, MNF116, and 34βE12 expression [4,62]. The epithelial origin of ghost cells was confirmed through CKs expression [7,[12][13][14][15][63][64][65].…”

Section: Discussionmentioning

confidence: 91%

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Vieira

Montovani

Rozza-De-Menezes

et al. 2021

Head and Neck Pathol

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Dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. The aim of this study was to perform a comparative systematic review of the clinicopathological, genetic, therapeutic, and prognostic features of DGCT and GCOC. The electronic search was performed until December 2020 on seven electronic databases. Case reports, series, and research studies with enough histopathological criteria for diagnosis and all genomic studies were included. Both DGCT and GCOC showed a male prevalence (p = 0.043), with mandibular and maxillary predilections, respectively (p = 0.008). Peripheral DGCT (DGCTp) affected most elderly people (p < 0.001), and central DGCT (DGCTc) and GCOC occurred mainly in younger individuals. Unilateral enlargement of maxilla or mandible was the most common clinical sign associated with a radiolucent or mixed image. Ameloblastomatous epithelium was often present in both neoplasms. Basaloid and large cells with vesicular nuclei were also frequently seen in GCOC. β-catenin expression and mutations (CTNNB1 gene) were found in DGCT and GCOC. Conservative surgery was mostly used for DGCTp, while radical resection was chosen for DGCTc and GCOC. High recurrence rates were found in DGCTc and GCOC. Metastasis occurred in 16.7% of GCOC cases and the 5-year survival rate was 72.6%. DGCT and GCOC share numerous clinicopathological features and demand a careful histopathological evaluation, considering the overlap features with other odontogenic tumors and the possibility of malignant transformation of DGCT. A strict regular post-operative follow-up is mandatory due to high recurrence rates and metastatic capacity in GCOC.

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Section: Discussionmentioning

confidence: 91%

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Vieira

Montovani

Rozza-De-Menezes

et al. 2021

Head and Neck Pathol

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“…4 In addition, the ghost cells in the lining epithelium of the COC are positive for amelogenin and CK6, but are negative for CK19. 5 Although the hybrid odontogenic tumor in our patients was quite extensive, basically it was a benign odontogenic tumor and can be treated by conservative excision with relatively good prognosis. However, long-term and regular follow-ups are needed for our patient.…”

mentioning

confidence: 72%

A hybrid odontogenic tumor of calcifying odontogenic cyst, ameloblastic fibroma, and complex odontoma

Chen

Lee

et al. 2022

Journal of Dental Sciences

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“…The 27 cases we searched for in this review consisted of 3 retrospective studies [ 9 – 11 ] and 13 case reports [ 12 – 24 ]. We added our case to these for this investigation.…”

Section: Discussionmentioning

confidence: 99%

Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature

et al. 2023

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Background Dentinogenic ghost cell tumor is a rare benign tumor that accounts for less than 3% of all cases and consists of the stellate reticulum, which is made up of enamel epithelioid and basaloid cells. Although DGCT is a benign tumor, the local infiltration of the odontogenic epithelium or recurrences have been reported, and its detailed pathology and treatments remain unclear. Case presentation This report describes the case of a 60-year-old Japanese male diagnosed with a maxillary dentinogenic ghost cell tumor. Images showed well-circumscribed, multilocular cystic lesions with a calcified substance in the interior. Marsupialization was performed along with biopsy to prevent the expansion of the lesion, and a partial maxillectomy was performed 2 years after the initial examination. Histopathological findings showed ameloblastomatous proliferation containing clusters of ghost cells and dentinoid materials, resulting in the diagnosis of dentinogenic ghost cell tumor. This article also reviews recently reported cases of dentinogenic ghost cell tumor. Conclusion It is important to perform marsupialization, proper resection, and postoperative follow-up because of possible recurrence.

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Ghost cell characterization in calcifying odontogenic cysts and dentinogenic ghost cell tumors: An immunohistochemical study

Cited by 7 publications

References 16 publications

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

A hybrid odontogenic tumor of calcifying odontogenic cyst, ameloblastic fibroma, and complex odontoma

Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: a case report and review of the literature

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