GH/GHBP changes in the perioperative course of liver transplantation: pathophysiologic and clinical implications

Cillo, Umberto; Bassanello, Marco; Lancerin, Federica; Senzolo, Marco; Burra, Patrizia; Montin, Umberto; Boccagni, Patrizia; Brolese, Alberto; Zanus, Giacomo; Graziotto, A.; Russo, F.P.; Gringeri, Enrico; D’Amico, Davide; Palo, Elio Franco De

doi:10.1016/s0041-1345(00)02809-8

Cited by 2 publications

(4 citation statements)

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“…Previous studies have reported a pivotal axis recovery after OLT in adult and pediatric patients . In an LDLT model, potential factors influencing the pattern of liver regeneration are diminished.…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies have reported a pivotal axis recovery after OLT in adult and pediatric patients. 8,[13][14][15][16][17][18][19] In an LDLT model, potential factors influencing the pattern of liver regeneration are diminished. Liver damage is comparable among patients (right lobe donation versus partial liver transplantation with a brief cold ischemia preservation time), and we would predict a certain similarity for the circulatory dynamics in the 2 groups because of the similar body mass indices.…”

Section: Discussionmentioning

confidence: 99%

“…However, these studies investigated either GH or IGF1 serum levels after OLT using deceased donor organs. 15,24 A comparison with healthy subjects undergoing partial hepatic resection is particularly difficult because this hormonal axis is rarely studied in patients undergoing LDLT. A case report of LDLT between identical twins showed decreasing IGF1 and GH serum levels in the donor, whereas a study of patients without cirrhosis undergoing partial resection reported decreased IGF1 levels and increased GH plasma levels after surgery.…”

Section: Discussionmentioning

confidence: 99%

“…These results are consistent with our current understanding of the postoperative hormonal course of GH/IGF1 signaling in liver transplant recipients, although some studies have shown different paces of hormone axis recovery. However, these studies investigated either GH or IGF1 serum levels after OLT using deceased donor organs . A comparison with healthy subjects undergoing partial hepatic resection is particularly difficult because this hormonal axis is rarely studied in patients undergoing LDLT.…”

Section: Discussionmentioning

confidence: 99%

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Growth hormone/insulin-like growth factor 1 dynamics in adult living donor liver transplantation

Jara

Schulz

Malinowski³

et al. 2014

Liver Transpl

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End-stage liver disease is accompanied by decreased serum levels of insulin-like growth factor 1 (IGF1) and inversely increased serum levels of growth hormone (GH). Previous reports have demonstrated rapid GH/IGF1 axis recovery after orthotopic liver transplantation. This study investigated the effect in an adult-to-adult living donor liver transplantation (LDLT) model and characterized GH/IGF1 alterations and liver regeneration in both donors and recipients. Sequential blood samples were prospectively collected from 30 donor-recipient pairs during the perioperative course of LDLT. A distinct set of biochemical parameters, including serum GH, serum IGF1, and standard liver blood tests, was analyzed at different time points (preoperatively and during 12 months of follow-up after surgery). Recipients showed significantly higher GH serum levels and lower IGF1 serum levels in comparison with donors before surgery and throughout the first postoperative days (PODs). The GH serum levels of recipients declined, whereas donor levels inversely increased during the early postoperative period to a normal range. Recipients' IGF1 serum levels were restored within the first operative week. In parallel, donor IGF1 levels decreased by 50% after living donation, and preoperative serum levels were restored after 6 months. Donors showed delayed recovery of liver function in comparison with recipients. The dynamics of IGF1 strongly correlated with routine laboratory parameters of liver function. In conclusion, recipients showed a rapid recovery of the GH/IGF1 hormonal axis and liver function after LDLT, whereas donors showed altered GH signaling and regenerative delay in the early PODs after living donation.

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Section: Discussionmentioning

confidence: 97%