GH and IGF‐I excess control contributes to blood pressure control: results of an observational, retrospective, multicentre study in 105 hypertensive acromegalic patients on hypertensive treatment

Abstract

Hypertensive patients with controlled acromegaly achieved improved control of hypertension and of cardiac diastolic and systolic function. The use of antihypertensive drugs was significantly less in patients achieving control of acromegaly.

The relationship between calcium metabolism, insulin-like growth factor-1 and pulse pressure in normotensive, normolipidaemic and non-diabetic patients

“…A negative relationship between adiposity and GH [23, 24] may be a theoretical explanation, but in our study men did not show a significant difference from others regarding BMI. These findings on relations between blood pressure and GH and IGF-1 levels are parallel with known observations in the medical literature as observed in special patient groups with acromegaly or sleep apnoea [3, 4]. Postmenopausal women with higher BMI did not reveal any relationship between PP and GH or IGF-1, probably because some other factors (such as age and BMI found in this study) dominate.…”

Effects of Initial Therapy for Five Years with Somatostatin Analogs for Acromegaly on Growth Hormone and Insulin-Like Growth Factor-I Levels, Tumor Shrinkage, and Cardiovascular Disease: A Prospective Study

“…In particular, 18 patients (40%) had mild left ventricular failure: only a minority of patients with acromegaly (Ͻ3%) is reported to have overt heart failure, which generally has a good prognosis in patients with controlled acromegaly (45). One major cause of persistent failure of left ventricular performance is persistent hypertension, which might be difficult to control in patients with uncontrolled acromegaly (46). In the current cohort, despite GH and IGF-I control and treatment of hypertension, 10 patients were still mildly hypertensive, 19 had persistent left ventricular hypertrophy, seven had persistent diastolic dysfunction, and two had persistent systolic dysfunction, indicating a selected group with severe cardiovascular disease.…”

Pattern of adrenal morphology and function in patients with acromegaly

“…The second speculation was a potential link between the adrenal functional changes and arterial hypertension very frequently observed in patients with acromegaly and associated with increased cardiovascular morbidity and mortality [6][7][8][9]. The second speculation was a potential link between the adrenal functional changes and arterial hypertension very frequently observed in patients with acromegaly and associated with increased cardiovascular morbidity and mortality [6][7][8][9].…”