“…With adequate sample size, treatment effects in the range of 0.5 to 1.00 mL/min/1.73 m 2 /y had 96% probability of predicting CKD progression, defined as doubling of serum creatinine, eGFR less than 15 mL/min/1.73 m 2 , or ESKD . eGFR slope can be used in patients with higher baseline eGFR values and may provide CKD progression insights when few hard kidney events are observed, especially in trials with limited follow-up . Assuming a normal kidney function trajectory based on eGFR or measured GFR of 1 mL/min/1.73 m 2 /y, literature categorizes slow kidney function trajectory as less than 3 mL/min/1.73 m 2 /y, fast as 3 to 5 mL/min/1.73 m 2 /y, and very fast as more than 5 mL/min/1.73 m 2 /y .…”