GFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing

Chen, Nan; Shi, Hao; Zhang, Luxia; Zuo, Li; Xie, Jingyuan; Xie, Dong; Karger, Amy B.; Miao, Shiyuan; Ren, Hong; Zhang, Wen; Wang, Weiming; Pan, Yisheng; Wei, Min-Ji; Sui, Zhun; Okparavero, Aghogho; Simon, Andrew; Chaudhari, Juhi; Eckfeldt, John H.; Inker, Lesley A.; Levey, Andrew S.

doi:10.1016/j.xkme.2019.11.004

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…and BTP was not more accurate than eGFR cr-cys in a combined population of 3 US cohorts with CKD, but the panel was more accurate than eGFR cr-cys in two Chinese cohorts including participants with and without CKD where eGFR cr was less accurate than in the US cohorts 26,27 .…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 75%

A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Inker

Couture

Tighiouart

et al. 2021

American Journal of Kidney Diseases

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 75%

A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Inker

Couture

Tighiouart

et al. 2021

American Journal of Kidney Diseases

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“…Recently, Inker LA et al nicely demonstrated that the incorporation of β2-Microglobulin and β-Trace Protein into adult prediction formulas improved their performance, without incorporating the race data [ 29 ]. Chen N et al also showed the beneficial addition of β2-Microglobulin and β-Trace Protein in improving GFR estimation in a Chinese population, however without significant clinical impact [ 30 ]. The utility of these two biomarkers in predicting GFR should be investigated further.…”

Section: Discussionmentioning

confidence: 99%

Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children

et al. 2021

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Glomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r2) in relation to iGFR and tested the improvement in variance explained by means of the likelihood ratio test. The combined Schwartz and the combined quadratic formulas yielded best results with an r2 of 0.676 and 0.730, respectively. The addition of BNP and PTH to the combined Schwartz and quadratic formulas improved the variance slightly. NGAL and albumin failed to improve the prediction of GFR further. These study results also confirm that the addition of cystatin C improves the performance of estimating GFR formulas, in particular the Schwartz formula.Conclusion: The addition of serum NGAL, BNP, PTH, and albumin to the combined Schwartz and quadratic formulas for estimating GFR did not improve GFR prediction in our population. What is Known:• Estimating glomerular filtration rate (GFR) formulas include serum creatinine and/or cystatin C but lack precision when compared to measured GFR.• The serum concentrations of some biological parameters such as neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) vary with the level of renal function. What is New:• The addition of BNP and PTH to the combined quadratic formula improved its performance only slightly. NGAL and albumin failed to improve the prediction of GFR further.

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“…It has been used as a marker of cerebrospinal fluid leakage since it is an important constituent of cerebral spinal fluid and is in much lower concentrations in blood [12]. Many studies have described and compared the diagnostic performance of BTP with the traditional markers of CKD [13][14][15], reporting that increased urinary and systemic BTP concentrations were highly correlated with creatinine and cystatin C concentrations [16,17]; moreover, the urinary concentration of BTP progressively increased, along with GFR reduction, and with a rise in its serum concentration [16]. A study conducted by Motawi et al (2017) showed that serum BTP was higher in type 2 diabetes (T2D) CKD patients with microalbuminuria than in patients with normoalbuminuria, suggesting the potential of BTP in the early diagnosis of diabetic nephropathy [18].…”

Section: New Biomarkers For Chronic Kidney Disease Managementmentioning

confidence: 99%

New Potential Biomarkers for Chronic Kidney Disease Management—A Review of the Literature

Lousa

Reis

Beirão

et al. 2020

IJMS

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The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality rate continues to be unacceptably high. The biomarkers currently used in clinical practice are considered relevant when there is already significant renal impairment compromising the early use of potentially successful therapeutic interventions. More sensitive and specific biomarkers to detect CKD earlier on and improve patients’ prognoses are an important unmet medical need. The aim of this review is to summarize the recent literature on new promising early CKD biomarkers of renal function, tubular lesions, endothelial dysfunction and inflammation, and on the auspicious findings from metabolomic studies in this field. Most of the studied biomarkers require further validation in large studies and in a broad range of populations in order to be implemented into routine CKD management. A panel of biomarkers, including earlier biomarkers of renal damage, seems to be a reasonable approach to be applied in clinical practice to allow earlier diagnosis and better disease characterization based on the underlying etiologic process.

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GFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing

Abstract: Complete author and article information provided before references.

Cited by 11 publications

References 30 publications

A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population

Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children

New Potential Biomarkers for Chronic Kidney Disease Management—A Review of the Literature

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