Getting there in one piece: The Rac pathway prevents cell fragmentation in a nonprotrusively migrating leader cell during organogenesis
Noor Singh,
Karen Jian Li,
Kacy Lynn Gordon
Abstract:SUMMARYTheC. eleganshermaphrodite distal tip cell (DTC) leads gonadogenesis. Loss-of-function mutations in aC. elegansortholog of the Rac1 GTPase (ced-10) and its GEF complex (ced-5/DOCK180,ced-2/CrkII,ced-12/ELMO) cause gonad migration defects related to directional sensing; we discovered an additional defect class of gonad bifurcation in these mutants. Using genetic approaches, tissue-specific and whole-body RNAi, andin vivoimaging of endogenously tagged proteins and marked cells, we find that loss of Rac1 o… Show more
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