Getting the powder mix right for design of bone implants

Friederici, Vera; Bruinink, A.; Imgrund, Philipp; Seefried, Selina

doi:10.1016/s0026-0657(11)70041-8

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…Subsequently, scientific study refined processing with a primary focus on oxygen with a target of improved as-sintered ductility and corrosion resistance. Several detailed studies emerged disclosing the processing cycles required for titanium and its alloys, as reviewed in recent papers [ 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 ]. Along the way, in spite of many industry skeptics, Ti-MIM reached production status for several mechanical components.…”

Section: Ti-mim Processing Optimizationmentioning

confidence: 99%

“…Most recently Ti-MIM has penetrated life critical applications in dental, aerospace, medical, and chemical devices [ 115 , 116 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 134 , 135 , 140 , 141 , 142 , 143 ]. Based on success at research institutions, the high quality Ti-MIM process has been put into production with variants by several firms.…”

Section: Ti-mim Processing Optimizationmentioning

confidence: 99%

“…Now the research turns to Ti-MIM materials for demanding applications and the progress is traced in several recent papers [ 114 , 115 , 116 , 117 , 118 , 119 , 124 , 125 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 ]. Much of this effort is focused on final properties, especially fatigue, as well as oxidation, corrosion, and various biocompatibility attributes.…”

Section: Ti-mim Processing Optimizationmentioning

confidence: 99%

“…Most importantly, progress in powder atomization provides the infrastructure platform to enable successful Ti-MIM. Accordingly, much effort is applied to form high purity titanium components using the Ti-MIM process [ 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 ].…”

Section: Introductionmentioning

confidence: 99%

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Progress in Titanium Metal Powder Injection Molding

German

2013

Materials

148

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Metal powder injection molding is a shaping technology that has achieved solid scientific underpinnings. It is from this science base that recent progress has occurred in titanium powder injection molding. Much of the progress awaited development of the required particles with specific characteristics of particle size, particle shape, and purity. The production of titanium components by injection molding is stabilized by a good understanding of how each process variable impacts density and impurity level. As summarized here, recent research has isolated the four critical success factors in titanium metal powder injection molding (Ti-MIM) that must be simultaneously satisfied—density, purity, alloying, and microstructure. The critical role of density and impurities, and the inability to remove impurities with sintering, compels attention to starting Ti-MIM with high quality alloy powders. This article addresses the four critical success factors to rationalize Ti-MIM processing conditions to the requirements for demanding applications in aerospace and medical fields. Based on extensive research, a baseline process is identified and reported here with attention to linking mechanical properties to the four critical success factors.

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Section: Ti-mim Processing Optimizationmentioning

confidence: 99%

Section: Ti-mim Processing Optimizationmentioning

confidence: 99%

Section: Ti-mim Processing Optimizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Progress in Titanium Metal Powder Injection Molding

German

2013

Materials

148

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“…It should be noted that osteoblast and osteoclast cells exist in a normal state. However, in the case of tissue inflammation, osteoclasts proliferate more and osteoblasts decrease, which has a negative effect on ossification and osteogenesis [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Osteoblastic Responses to Titanium and Alumina-Toughened Zirconia Implants: An In Vitro Study

Saberian,

Jenča,

Seyfaddini

et al. 2024

Biomolecules

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Introduction: Osteoblastic responses play a crucial role in the success of oral implants. Enhanced proliferation of osteoblast cells is associated with reduced cell mortality and an increase in bone regeneration. This study aims to evaluate the osteoblastic responses following oral implantation. Materials and Methods: Osteoblast stem cells were harvested and subsequently cultivated using cell culture techniques. The osteoblastic phenotype of the extracted cells was confirmed by examining the extracellular matrix. Cell morphogenesis on functionalized biomaterial surfaces was assessed through indirect immunofluorescence staining. The cellular response was investigated in the presence of two types of implant materials: titanium (Ti) and alumina-toughened zirconia (ATZ). Cell viability and apoptosis were quantitatively assessed using MTT assays and flow cytometry, respectively. Results: The survival of osteoblastic lineage cells was moderately reduced post-implantation. Viability in the Ti implant group remained at approximately 86%, while in the ATZ group, it was observed at 75%, which is considered acceptable. Moreover, there was a significant disparity in cell survival between the two implant groups (p < 0.05). Analysis of apoptosis levels at various concentrations revealed that the rate of apoptosis was 3.6% in the control group and 18.5% in the ATZ group, indicating that apoptosis or programmed cell death in the ATZ-treated group had increased nearly four-fold (p < 0.05). Conclusions: The findings of this study indicate a reduction in osteoblastic cell line survival following implant treatment, with titanium implants exhibiting superior performance in terms of cell survival. However, it was also noted that the incidence of apoptosis in osteoblast cells was significantly higher in the presence of zirconium-based implants.

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Future Prospects for Sintering

German¹

2014

Sintering: From Empirical Observations to Scientific Principles

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Getting the powder mix right for design of bone implants

Abstract: Very good biocompatibility makes titanium the material of choice for permanent metallic bone implants. Work carried out in Germany and Switzerland shows that -MIM offers a promising route to designed regular micro-sized patterns on implant surfaces that enhance osteointegration..

Cited by 4 publications

References 2 publications

Progress in Titanium Metal Powder Injection Molding

Progress in Titanium Metal Powder Injection Molding

Comparative Analysis of Osteoblastic Responses to Titanium and Alumina-Toughened Zirconia Implants: An In Vitro Study

Future Prospects for Sintering

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