Getting paralysed after COVID

Mehta, Sameer Kr.; Sunder, Ashok

doi:10.4103/jfmpc.jfmpc_2454_20

Cited by 5 publications

(11 citation statements)

References 10 publications

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“…We read with interest the article by Mehta et al . [ 1 ] about an 84-year-old male who was diagnosed with Guillain--Barre syndrome (GBS) 22 days after onset of COVID-19. For COVID-19, the patient had received nasal oxygen, steroids, remdesivir, tocilizumab, and convalescent plasma.…”

mentioning

confidence: 99%

“…For COVID-19, the patient had received nasal oxygen, steroids, remdesivir, tocilizumab, and convalescent plasma. [ 1 ] For GBS he received immunoglobulins and recovered completely until dismissal from the hospital. [ 1 ] The study is appealing but raises comments and concerns.…”

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confidence: 99%

“…[ 1 ] For GBS he received immunoglobulins and recovered completely until dismissal from the hospital. [ 1 ] The study is appealing but raises comments and concerns.…”

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confidence: 99%

“…We do not agree with the statement in the discussion that most SARS-CoV-2 associated GBS cases were aged over 50 years. [ 1 ] In a study of SARS-CoV-2 associated GBS patients published between January 2021 and the end of June 2021, at least 20 of 75 patients were under age 50 years [Finsterer, submitted]. Four of the 75 included patients were even below 20 years of age.…”

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confidence: 99%

“…We do not agree with the conclusion that the increased frequency of respiratory failure in SARS-CoV-2 associated GBS compared to non-COVID-19 GBS is due to affection of both, lungs and the nerve roots. [ 1 ] Since it is difficult to differentiate to which degree respiratory failure is due to GBS or due to COVID-19 pneumonia and no studies about this issue are available, the influence of both conditions on respiratory functions remains speculative. However, since some patients with SARS-CoV-2 associated GBS experience only subclinical or mild COVID-19 infection and do not have pneumonia, it is conceivable that respiratory failure is entirely due affection of the respiratory muscles in GBS at least in some patients.…”

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confidence: 99%

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Unvaccinated patients may still experience SARS-CoV-2 associated polyradiculitis

Finsterer

2022

Journal of Family Medicine and Primary Care

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confidence: 99%

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confidence: 99%

“…[ 1 ] For GBS he received immunoglobulins and recovered completely until dismissal from the hospital. [ 1 ] The study is appealing but raises comments and concerns.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Unvaccinated patients may still experience SARS-CoV-2 associated polyradiculitis

Finsterer

2022

Journal of Family Medicine and Primary Care

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Exposure to SARS-CoV-2 and Infantile Diseases

Kanduc

2023

Glob Med Genet

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Background and Aim Immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in newborns and children after prophylactic immunization is currently a relevant research topic. The present study analyzes the issue by examining the possibility that the anti-SARS-CoV-2 immune responses are not uniquely directed against the virus but can—via molecular mimicry and the consequent cross-reactivity—also hit human proteins involved in infantile diseases. Methods Human proteins that—if altered—associate with infantile disorders were searched for minimal immune pentapeptide determinants shared with SARS-CoV-2 spike glycoprotein (gp). Then, the shared pentapeptides were analyzed for immunologic potential and immunologic imprinting phenomena. Results Comparative sequence analysis shows that: (1) numerous pentapeptides (namely, 54) are common to SARS-CoV-2 spike gp and human proteins that, when altered, are linked to infantile diseases; (2) all the shared peptides have an immunologic potential since they are present in experimentally validated SARS-CoV-2 spike gp-derived epitopes; and (3) many of the shared peptides are also hosted in infectious pathogens to which children can have already been exposed, thus making immunologic imprint phenomena feasible. Conclusion Molecular mimicry and the consequent cross-reactivity can represent the mechanism that connects exposure to SARS-CoV-2 and various pediatric diseases, with a fundamental role of the immunologic memory and the history of the child's infections in determining and specifying the immune response and the pathologic autoimmune sequela.

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Peripheral nervous system involvement associated with COVID-19. A systematic review of literature

et al. 2023

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There is increasing evidence of both central and peripheral nervous system (PNS) involvement in COVID-19. We conducted this systematic literature review to investigate the characteristics, management and outcomes of patients with PNS, including the types and severity of cranial nerves (CN) involvement. We systematically searched on PubMed for studies reporting adult patients diagnosed with COVID-19 and PNS involvement until July 2021. From 1670 records, 225 articles matched the inclusion criteria, with a total of 1320 neurological events, in 1004 patients. There were 805 (61%) CN, 350 (26.5%) PNS, and 165 (12.5%) PNS plus CN events. The most frequently involved CN were the facial, vestibulo-cochlear and olfactory nerve in 27.3%, 25.4% and 16.1%, respectively. Guillain-Barre syndrome spectrum was identified in 84.2% of PNS events. We analysed 328 patients reported in 225 articles with CN, PNS, and PNS plus CN involvement. The patients with CN involvement were younger (mean age 46.2±17.1, p = .003), and were more frequently treated as outpatients (p < .001), mostly with glucocorticoids (p < .001). Patients that had PNS with or without CN involvement were more likely to be hospitalized (p < .001), and to receive intravenous immunoglobulins (p = .002) or plasma exchange (p = .002). Patients with CN, PNS, and PNS plus CN had severe COVID -19 disease in 24.8%, 37.3%, 34.9% respectively. The most common neurological outcome was mild/moderate sequelae in patients with CN, PNS, and PNS plus CN in 54.7%, 67.5% and 67.8% respectively (p = .1) and no significant difference was found between the three categories regarding death, disease severity, time from disease onset to neurological symptoms, lack of improvement and complete recovery. CN involvement was the most frequent PNS finding. All three categories of PNS involvement were rather associated to non-severe COVID-19 but it may be an important cause of hospitalization and post COVID-19 sequelae.

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Getting paralysed after COVID

Cited by 5 publications

References 10 publications

Unvaccinated patients may still experience SARS-CoV-2 associated polyradiculitis

Unvaccinated patients may still experience SARS-CoV-2 associated polyradiculitis

Exposure to SARS-CoV-2 and Infantile Diseases

Peripheral nervous system involvement associated with COVID-19. A systematic review of literature

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