1995
DOI: 10.1002/jcb.240580404
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Getting human gene therapy to work

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Cited by 5 publications
(3 citation statements)
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“…Many of these studies employed adenoviral vectors as the vehicles for introduction of the wtp53 (Liu et al, 1994Fujiwara et al, 1994;Clayman et al, 1995;Srivastava et al, 1995;Shaw et al, 1992). The use and advantages of adenovirus for gene therapy have been recently reviewed (Bramson et al, 1995;Blau et al, 1995;Stewart, 1995). Due to its natural a nity for the epithelium of the aerodigestive tract, adenovirus is the best vehicle currently available for gene therapy studies of head and neck cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Many of these studies employed adenoviral vectors as the vehicles for introduction of the wtp53 (Liu et al, 1994Fujiwara et al, 1994;Clayman et al, 1995;Srivastava et al, 1995;Shaw et al, 1992). The use and advantages of adenovirus for gene therapy have been recently reviewed (Bramson et al, 1995;Blau et al, 1995;Stewart, 1995). Due to its natural a nity for the epithelium of the aerodigestive tract, adenovirus is the best vehicle currently available for gene therapy studies of head and neck cancer.…”
Section: Discussionmentioning
confidence: 99%
“…The first gene therapy protocol to correct a genetic defect began in 1990 and was designed to treat a girl with adenosine deaminase deficiency by giving her autologous T cells that had been transduced ex vivo with a retrovirus encoding the normal gene (Blaese et al, 1995). Since that time, a variety of gene delivery techniques have been used in human trials (Crystal, 1995;Stewart, 1995).…”
Section: Introductionmentioning
confidence: 99%
“…Success of antisense and gene therapy depends on providing effective methods for delivery of the drugs to the site of action [1,2]. Nonviral delivery methods such as liposome-mediated DNA delivery systems offer a major advantage over the viral-based methods since lipids are less immunogenic and thus are better tolerated than virus vectors for use in in vivo systems.…”
Section: Introductionmentioning
confidence: 99%