Getting his act together: Roles of glutamate, nitric oxide, and dopamine in the medial preoptic area

Hull, Elaine M.; Domínguez, Juan M.

doi:10.1016/j.brainres.2006.08.031

Cited by 162 publications

(104 citation statements)

References 48 publications

Supporting

Mentioning

101

Contrasting

Order By: Relevance

“…Male sexual behavior is well defined within this network (Newman, 1999), with a more central role for the POA (Heimer and Larsson, 1967;Hull and Dominguez, 2006). Similarly, thanks to the pioneering work by Pfaff and Sakuma (1979) delineating the lordosis circuit, in females this network also mediates sexual behavior, with a central role for the VMH (Malsbury et al, 1977).…”

Section: Social Behavior Networkmentioning

confidence: 98%

“…It is located in the hypothalamus conspicuously along the third ventricle and ventral to the anterior commissure. It mediates aggression, sexual behavior, and parental care (Table 1) (Heimer and Larsson, 1967;Malsbury, 1971;Hull and Dominguez, 2006;Lee and Brown, 2007), and contains tyrosine hydroxylase (TH)-and neuropeptide-expressing cells as well as sex steroid receptors (Wang et al, 1996;Rosen et al, 2007;Holmes et al, 2008). It is reciprocally connected to many limbic brain regions, especially those in the SBN (Conrad and Pfaff, 1975).…”

Section: Preoptic Area (Poa) Mammalsmentioning

confidence: 99%

“…In general, regions of the SBN form an interactive network, and a single node can be involved in mediating many behaviors, such as various forms of aggression (Hayden-Hixon and Ferris, 1991;Delville et al, 2000;Nelson and Trainor, 2007;Fuxjager et al, 2010). For instance, the POA mediates male-male aggression (Albert et al, 1986), male sexual behavior (Heimer and Larsson, 1967;Hull and Dominguez, 2006), and maternal care (Miceli and Malsbury, 1982;Lee and Brown, 2007). As many of the hypothalamic and midbrain nodes of the SBN are downstream of sensory processing areas, and thus associative in nature, it should come as no surprise that this circuit is also considered fundamental to more complex tasks such as social cognition (Ferguson et al, 2002).…”

Section: Social Behavior Networkmentioning

confidence: 99%

See 2 more Smart Citations

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

853

879

View full text Add to dashboard Cite

All animals evaluate the salience of external stimuli and integrate them with internal physiological information into adaptive behavior. Natural and sexual selection impinge on these processes, yet our understanding of behavioral decision-making mechanisms and their evolution is still very limited. Insights from mammals indicate that two neural circuits are of crucial importance in this context: the social behavior network and the mesolimbic reward system. Here we review evidence from neurochemical, tract-tracing, developmental, and functional lesion/stimulation studies that delineates homology relationships for most of the nodes of these two circuits across the five major vertebrate lineages: mammals, birds, reptiles, amphibians, and teleost fish. We provide for the first time a comprehensive comparative analysis of the two neural circuits and conclude that they were already present in early vertebrates. We also propose that these circuits form a larger social decision-making (SDM) network that regulates adaptive behavior. Our synthesis thus provides an important foundation for understanding the evolution of the neural mechanisms underlying reward processing and behavioral regulation. J. Comp. Neurol. 519:3599-3639, 2011. INDEXING TERMS: social behavior; comparative neuroanatomy; amphibian; reptile; bird; teleost; reward system; social behavior network; limbic system; neural circuitsThroughout their lives, all animals constantly face situations that provide either challenges (e.g., aggression, predation) or opportunities (e.g., reproduction, foraging, habitat selection) (for a detailed review, see O'Connell and Hofmann, 2011). In all cases, environmental cues are processed by sensory systems into a meaningful biological signal while internal physiological cues (e.g., condition, maturity) and prior experience are integrated at the same time. This process usually results in behavioral actions that are adaptive, i.e., beneficial to the animal. To accomplish this, an animal's nervous system must evaluate the salience of a stimulus and elicit a context-appropriate behavioral response. Despite tremendous progress in understanding the ecology and evolution of social behavior (Lorenz, 1952;Tinbergen, 1963;Lehrman, 1965;von Frisch, 1967;Krebs and Davies, 1993;Stephens, 2008), it is less understood where in the brain these decisions (e.g., about mate choice or territory defense) are made and how these brain circuits have arisen over the course of vertebrate evolution.Recent research has begun to decipher the neural basis of social decision-making. In mammals in particular, the neural circuits that evaluate stimulus salience and/or regulate social behavior have been uncovered to some degree: the mesolimbic reward system and social behavior network (Fig. 1). It is becoming increasingly clear that the reward system (including but not limited to the midbrain dopaminergic system) is the neural circuit where the salience of an external stimulus is evaluated (Deco and Rolls, 2005;Wickens et al., 2007), as appetitive beh...

show abstract

Section: Social Behavior Networkmentioning

confidence: 98%

Section: Preoptic Area (Poa) Mammalsmentioning

confidence: 99%

Section: Social Behavior Networkmentioning

confidence: 99%

See 1 more Smart Citation

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

853

879

View full text Add to dashboard Cite

show abstract

“…Central dopamine (DA) plays an important role in most, if not all, of the key cognitive and behavioral processes associated with pair bonding including olfaction, sexual behavior, learning, memory, and conditioning (Mitchell et al, 1992;Cheng et al, 2003;Hull et al, 2004;Hull et al, 2006;Lemon et al, 2006;Tillerson et al, 2006;El-Ghundi et al, 2007). DA, particularly in mesolimbic brain regions, has also been implicated in the mediation of a variety of natural rewards (Wise et al, 1989;Bozarth, 1991) including mating (Everitt, 1990) which facilitates pair bonding (Carter et al, 1990;Williams et al, 1992b;Insel et al, 1995b;Curtis et al, 2003a;Wang et al, 2004).…”

Section: Dopaminergic Regulation Of Social Attachment Indeedmentioning

confidence: 99%

“…Although various animal models have been developed to study social behaviors ubiquitous to mammalian species, including mating, maternal care, and aggression (Seay et al, 1962;Coe et al, 1978;Kendrick et al, 1992;Nelson et al, 2001;Weller et al, 2003;Levy et al, 2004;Moriceau et al, 2005;Hull et al, 2006;Hull et al, 2007;Nelson et al, 2007), the formation of strong bonds between mating pairs (pair bonding), and behaviors associated with these bonds, such as mate guarding (selective aggression) and paternal care, have been understudied, perhaps due to the lack of appropriate animal models. These behaviors are relatively uncommon in the animal kingdom, and in mammals are only displayed by the 3-5% of species that are monogamous (Kleiman, 1977).…”

Section: Introductionmentioning

confidence: 99%

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies

Young

Liu

Wang

2008

Comparative Biochemistry and Physiology Part C: Toxicology &

132

View full text Add to dashboard Cite

The formation and maintenance of social bonds in adulthood is an essential component of human health. However studies investigating the underlying neurobiology of such behaviors have been scarce. Microtine rodents offer a unique comparative animal model to explore the neural processes responsible for pair bonding and its associated behaviors. Studies using monogamous prairie voles and other related species have recently offered insight into the neuroanatomical, neurobiological, and neurochemical underpinnings of social attachment. In this review, we will discuss the utility of the microtine rodents in comparative studies by exploring their natural history and social behavior in the laboratory. We will then summarize the data implicating vasopressin, oxytocin, and dopamine in the regulation of pair bonding. Finally, we will discuss the ways in which these neurochemical systems may interact to mediate this complex behavior.

show abstract

Central Nervous System Anatomy and Neurochemistry of Sexual Desire

Pfaus¹,

Jones²

2018

Textbook of Female Sexual Function and Dysfunction

View full text Add to dashboard Cite

Getting his act together: Roles of glutamate, nitric oxide, and dopamine in the medial preoptic area

Cited by 162 publications

References 48 publications

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies

Central Nervous System Anatomy and Neurochemistry of Sexual Desire

Contact Info

Product

Resources

About