Getting educated on care for the LGBTQ community

Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation of time-resolved micro-tomography images

“…Thus highlighting that care should be taken when choosing the combination of the lubricant and the disintegrant for a given formulation. Magnesium stearate increased the swelling intensity score compared to sodium stearyl fumarate partially due to their different size differences but more likely owing to their different aqueous solubility [ 101 ]. As the swelling is promoted by the liquid imbibition, it is sensitive to the surface-liquid contact interface properties, i.e., how hydrophobic the surface is.…”

“…Hydroxypropyl methylcellulose in a formulation increased this score, while polyethylene oxide lowered it. The linear polymer structure of PEO suggests fast water binding ability but also the formation of weaker, erodible gels [ 101 , 103 ]. Therefore, in the presence of factors facilitating erosion of the polyethylene oxide gel, the swelling intensity is not as prominent, as seen from this study's experimental data.…”

“…We suggest our finding on the interaction of Fujicalin with magnesium stearate to reflect the general tendency of magnesium stearate to slow down the disintegration of formulations. In contrast, sodium stearyl fumarate is less hydrophobic and thus affects tablet dissolution less [ 101 ].…”