Getah Virus as an Equine Pathogen

Fukunaga, Yoshio; Kumanomido, Takeshi; Kamada, Masanobu

doi:10.1016/s0749-0739(17)30099-8

Cited by 64 publications

(54 citation statements)

References 52 publications

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“…Getah virus is transmitted mainly among horses and pigs, and it has not been linked to human illness (12)(13)(14). Also, M1 does not cause apparent disease symptoms in mice or rats, even on administration of doses up to 3 × 10 7 pfu per mouse or 3 × 10 8 pfu per rat.…”

mentioning

confidence: 99%

Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers

Lin¹,

Zhang²,

Liang³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

122

124

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Oncolytic virotherapy is a growing treatment modality that uses replicating viruses as selective antineoplastic agents. Safety and efficacy considerations dictate that an ideal oncolytic agent would discriminate between normal and cancer cells on the basis of common genetic abnormalities in human cancers. Here, we identify a naturally occurring alphavirus (M1) as a novel selective killer targeting zinc-finger antiviral protein (ZAP)-deficient cancer cells. In vitro, in vivo, and ex vivo studies showed potent oncolytic efficacy and high tumor tropism of M1. We showed that the selectivity depends on ZAP deficiency by systematic identification. A large-scale multicenter pathology study using tissue microarrays reveals that ZAP is commonly deficient in human cancers, suggesting extensive application prospects for M1. Additionally, M1 killed cancer cells by inducing endoplasmic reticulum stress-mediated apoptosis. Our report provides novel insights into potentially personalized cancer therapy using oncolytic viruses.

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mentioning

confidence: 99%

Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers

Lin¹,

Zhang²,

Liang³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

122

124

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“…It is the only alphavirus to emerge into an urban or peridomestic cycle, where the virus is transmitted by anthrophilic mosquitoes from human-to-human with no involvement of wild animals as amplification or reservoir hosts. Among this group of viruses in the Semliki Forest complex, some such as Una virus (UNAV) and Getah virus (GETV), cause little or no human disease but do cause disease in horses (15,24).…”

mentioning

confidence: 99%

Genome-Scale Phylogeny of the Alphavirus Genus Suggests a Marine Origin

Forrester

Palacios

Tesh

et al. 2012

J Virol

137

121

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The genus Alphavirus comprises a diverse group of viruses, including some that cause severe disease. Using full-length sequences of all known alphaviruses, we produced a robust and comprehensive phylogeny of the Alphavirus genus, presenting a more complete evolutionary history of these viruses compared to previous studies based on partial sequences. Our phylogeny suggests the origin of the alphaviruses occurred in the southern oceans and spread equally through the Old and New World. Since lice appear to be involved in aquatic alphavirus transmission, it is possible that we are missing a louse-borne branch of the alphaviruses. Complete genome sequencing of all members of the genus also revealed conserved residues forming the structural basis of the E1 and E2 protein dimers.

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“…GETV is maintained in nature by zoonotic transmission cycles involving nonhuman primate/vertebrate hosts and primary arthropod vectors (9). In these cycles, horses and pigs are amplifying hosts for GETV (10).…”

Section: Getah Virus (Getv) Is a Member Of The Genusmentioning

confidence: 99%

Development and Evaluation of Indirect ELISA for Detection of Antibodies to Getah Virus in Horse Serum

et al. 2016

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Getah virus (GETV) is a member of the genus Alphavirus in the family Togaviridae. GETV infection can occur in a wide range of vertebrate species, and the virus has been known for a pathogen of horses and pigs. To rapidly and accurately diagnose GETV infection of a racehorse, an indirect ELISA (I-ELISA) was developed in the present study for detection of antibodies to GETV in serum samples. To evaluate the developed I-ELISA, a total of 240 serum samples from Thoroughbred racehorses raised in Korea were screened in parallel by a serum neutralization (SN) test. The developed I-ELISA exhibited an efficacy comparable to that of the SN test in terms of a high diagnostic sensitivity (86.3%) and specificity (94.5%) at a cut-off absorbance value of 0.25. In addition, our results showed that the developed I-ELISA had a significant correlation with the SN test (r = 0.91; p < 0.05). Taken together, our findings suggest that the I-ELISA developed in this study is a valuable diagnostic tool for the screening of horses suspected to be infected with GETV.

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Getah Virus as an Equine Pathogen

Cited by 64 publications

References 52 publications

Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers

Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers

Genome-Scale Phylogeny of the Alphavirus Genus Suggests a Marine Origin

Development and Evaluation of Indirect ELISA for Detection of Antibodies to Getah Virus in Horse Serum

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