Gesundheitsbezogene Lebensqualität

Scheffold, Christian; Haller, M.; Briegel, Josef; Meier, M.; Manert, W.; Hummel, Theresia; Heyduck, M; Lenhart, Andreas; Polasek, J; Bullinger, Monika; Schelling, Gustav

doi:10.1007/s001010050518

Cited by 38 publications

(4 citation statements)

References 11 publications

(13 reference statements)

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“…1). A total of 21 articles [10,15,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41] describing 13 unique patient cohorts (n = 557) were eligible for the review (Table 1). Reviewer agreement on selection of abstracts for full-text evaluation was 93% (κ = 0.77) and for inclusion of articles in the final review was 100%.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Quality of life after acute respiratory distress syndrome: a meta-analysis

et al. 2006

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Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Quality of life after acute respiratory distress syndrome: a meta-analysis

et al. 2006

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“…It is noteworthy that the incidence of delirium may be very high in patients that underwent prolonged mechanical ventilation under sedation. In ICU patients experiencing hallucinations, delusions, nightmares, and altered sense of reality have been frequently reported [39,40] and may favor the development of post-traumatic stress syndrome after patient dismission [41]. As far as 80% general ICU patients may experience delirium [6].…”

Section: Incidencementioning

confidence: 99%

Postoperative Delirium

Cavaliere¹,

Dambrosio²,

Volpe³

et al. 2005

CDT

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Delirium is a global impairment of upper brain functions caused by an organic substrate. It is frequently observed in the postoperative period, particularly in elderly people. Vascular and orthopedic surgery and long-duration surgery are associated with a higher incidence of postoperative delirium. When it occurs, postoperative delirium makes patient management much more difficult, increases costs, and, above all, causes severe discomfort to the patient. Delirium is also associated with higher postoperative mortality and morbidity, and with delayed functional recovery, but it is still unclear whether worse prognosis is directly caused by delirium or results from the neurological damage of which delirium is simply a symptom. Drug therapy should be part of a complex approach to prevent and treat this complication. Neuroleptics like haloperidol and droperidol, and benzodiazepines are usually employed in order to control symptoms like agitation, restlessness, and altered perceptions. Atypical neuroleptics, like risperidone, have not yet been studied in postoperative delirium, although some case reports in which they were successfully used have been published. Physiostigmine is effective in delirium caused by anticholinergic syndrome; vitamins may be useful in alcoholics; melatonin use has been suggested in order to prevent and treat delirium by normalizing sleep-wake cycle alterations. Environmental interventions are often costless and may be very useful to prevent and treat postoperative delirium in patients at risk.

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“…There is some controversy regarding the quality of life after ECMO. 37 Some studies reported a benefit of ECMO over conventional MV, 26,38 while others reported worse outcomes for ECMO 39,40 or no difference. 41 For this study, we select the health-related quality of life reported by the CESAR Trial and by Kanji et al 37 However, two critical patients of the same age who need ECMO, even if one has a 10% possibility of surviving and the other 90%, both have the same QALY.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the discrimination and calibration of predictive scores of mortality in ECMO for patients with COVID‐19

et al. 2023

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Background The criteria for the selection of COVID‐19 patients that could benefit most from ECMO organ support are yet to be defined. In this study, we evaluated the predictive performance of ECMO mortality predictive models in patients with COVID‐19. We also performed a cost–benefit analysis depending on the mortality predicted probability. We conducted a retrospective cohort study in COVID‐19 patients who received ECMO at two tertiary care hospitals between March 2020 to July 2021. Materials and Methods We evaluated the discrimination (C‐statistic), calibration (Cox calibration), and accuracy of the prediction of death due to severe ARDS in V‐V ECMO score (PRESERVE), the Respiratory Extracorporeal Membrane Oxygenation Survival Score (RESP) score, and the PREdiction of Survival on ECMO Therapy‐Score (PRESET) score. In addition, we compared the RESP score with Plateau pressure instead of Peak pressure. Results We included a total of 36 patients, 29 (80%) of them male and with a median (IQR) APACHE of 10 (8–15). The PRESET score had the highest discrimination (AUROCs 0.81 [95%CI 0.67–0.94]) and calibration (calibration‐in‐the‐large 0.5 [95%CI −1.4 to 0.3]; calibration slope 2.2 [95%CI 0.7/3.7]). The RESP score with Plateau pressure had higher discrimination than the conventional RESP score. The cost per QALY in the USA, adjusted to life expectancy, was higher than USD 100 000 in patients older than 45 years with a PRESET > 10. Conclusion The PRESET score had the highest predictive performance and could help in the selection of patients that benefit most from this resource‐demanding and highly invasive organ support.

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Gesundheitsbezogene Lebensqualität

Cited by 38 publications

References 11 publications

Quality of life after acute respiratory distress syndrome: a meta-analysis

Quality of life after acute respiratory distress syndrome: a meta-analysis

Postoperative Delirium

Evaluation of the discrimination and calibration of predictive scores of mortality in ECMO for patients with COVID‐19

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