Gestationally dependent immune organization at the maternal-fetal interface

Moore, Allan F.; Gonzalez, Nora Vivanco; Plummer, Katherine A.; Mitchel, Olivia; Kaur, Harleen; Rivera, Moises; Collica, Brian; Goldston, Mako; Filiz, Ferda; Angelo, Michael; Palmer, Theo; Bendall, Sean C.

doi:10.1016/j.celrep.2022.111651

Cited by 7 publications

(5 citation statements)

References 98 publications

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“…Studies regarding neutrophils at the feto-maternal interface have indicated that proper neutrophil infiltration plays an important role in the normal development of the fetus. In recent mouse studies, neutrophil depletion using anti-Gr1 or Ly6G antibodies resulted in inadequate blastocyst implantation as well as altered placenta development in pregnant mice [ 7 , 36 ], suggesting that neutrophils are important during the early stages of pregnancy [ 21 ]. Herein, we determined whether MPO, which is predominantly expressed by neutrophils and released into the extracellular space, plays a role during placentation.…”

Section: Discussionmentioning

confidence: 99%

“…In the placenta, the presence of neutrophils and MPO in the DB has been confirmed [ [4] , [5] , [6] , [7] , 20 , 21 ]. Furthermore, higher MPO levels on the surface of blood neutrophils have been observed during pregnancy [ 22 ]; however, its abundance and role during first trimester implantation and placentation remains unclear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells

Mihalic,

Kloimböck,

Cosic-Mujkanovic

et al. 2023

Redox Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells

Mihalic,

Kloimböck,

Cosic-Mujkanovic

et al. 2023

Redox Biology

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“…Therefore, the modulatory effects of ECS on fertilization, blastocyst implantation, placentation, labor, and parturition might be partially mediated by the regulation of the innate and adaptive immune response at the interface between embryo and decidua, enriched in immune cells [ 152 ]. Indeed, the maternal decidua hosts numerous populations of immune cells, such as decidual NK cells, macrophages, dendritic cells, cytotoxic, regulatory and helper T lymphocytes, and B lymphocytes, that dynamically change in a gestational stage-dependent manner, and show distinct signatures from their counterparts in other tissues or in the bloodstreams [ 153 , 154 ]. These immune cells represent the first line of defence against the pathogen colonization of the placenta [ 155 ] and are responsible for the establishment of maternal immune tolerance, a modulation of the immune response necessary to avoid the allogeneic risk due to the foreign paternal antigens expressed on the fetal tissues [ 156 ].…”

Section: The Role Of Endocannabinoids In Low-grade Inflammation and M...mentioning

confidence: 99%

Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy

Rava

Trezza

2023

IJMS

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In recent years, Cannabis use/misuse for treating pregnancy-related symptoms and other chronic conditions has increased among pregnant women, favored by decriminalization and/or legalization of its recreational uses in addition to its easy accessibility. However, there is evidence that prenatal Cannabis exposure might have adverse consequences on pregnancy progression and a deleterious impact on proper neurodevelopmental trajectories in the offspring. Maternal Cannabis use could interfere with the complex and finely controlled role performed by the endocannabinoid system in reproductive physiology, impairing multiple gestational processes from blastocyst implantation to parturition, with long-lasting intergenerational effects. In this review, we discuss current clinical and preclinical evidence regarding the role of endocannabinoids in development, function, and immunity of the maternal–fetal interface, focusing on the impact of Cannabis constituents on each of these gestational processes. We also discuss the intrinsic limitations of the available studies and the future perspectives in this challenging research field.

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“…Recent research has uncovered that PD-L1 is abundantly present in breast stem cells and promotes the development and regeneration of mammary glands, offering new insights into the physiological functions of PD-L1 [ 29 ]. During pregnancy, the expression of PD-L1 in the placenta contributes to the maternal immune tolerance to fetal antigens and prevents immune attacks on the fetus [ 30 ]. A study has shown that PD-L1 + senescent cells, which are resistant to T cell surveillance, gradually accumulate with ageing.…”

Section: Introductionmentioning

confidence: 99%

Regulatory mechanisms of PD-1/PD-L1 in cancers

Lin,

Kang,

Chen

et al. 2024

Mol Cancer

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Immune evasion contributes to cancer growth and progression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. The programmed death protein 1 (PD-1) and programmed cell death ligands (PD-Ls) are considered to be the major immune checkpoint molecules. The interaction of PD-1 and PD-L1 negatively regulates adaptive immune response mainly by inhibiting the activity of effector T cells while enhancing the function of immunosuppressive regulatory T cells (Tregs), largely contributing to the maintenance of immune homeostasis that prevents dysregulated immunity and harmful immune responses. However, cancer cells exploit the PD-1/PD-L1 axis to cause immune escape in cancer development and progression. Blockade of PD-1/PD-L1 by neutralizing antibodies restores T cells activity and enhances anti-tumor immunity, achieving remarkable success in cancer therapy. Therefore, the regulatory mechanisms of PD-1/PD-L1 in cancers have attracted an increasing attention. This article aims to provide a comprehensive review of the roles of the PD-1/PD-L1 signaling in human autoimmune diseases and cancers. We summarize all aspects of regulatory mechanisms underlying the expression and activity of PD-1 and PD-L1 in cancers, including genetic, epigenetic, post-transcriptional and post-translational regulatory mechanisms. In addition, we further summarize the progress in clinical research on the antitumor effects of targeting PD-1/PD-L1 antibodies alone and in combination with other therapeutic approaches, providing new strategies for finding new tumor markers and developing combined therapeutic approaches.

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Gestationally dependent immune organization at the maternal-fetal interface

Cited by 7 publications

References 98 publications

Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells

Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells

Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy

Regulatory mechanisms of PD-1/PD-L1 in cancers

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