Gestational weight gain, appetite‐regulating hormones and metformin treatment in polycystic ovary syndrome: The importance of exclusion criteria

Free leptin index, excessive weight gain, and metformin treatment during pregnancy in polycystic ovary syndrome: What about inflammation?

“…Dear Dr Papageorghiou, We thank Fejzo et al for their paper 'Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum,' 1 which demonstrates that a genetic predisposition of GDF15/GFRAL/RET signalling is involved in Hyperemesis Gravidarum (HG), confirming their previous study. 2 They also added that, as no other exome-wide significant or causal variants in ≥10 cases were identified, their study does not support the two predominant historical theories that HG has a psychological origin or is caused by the pregnancy hormone human chorionic gonadotropin (hCG).…”

“…Dear Dr. Papageorghiou, We thank Zhera and Shah 1 for their interest in our study and welcome the opportunity to clarify the issue of exclusion criteria in 'Gestational weight gain, appetite regulating hormones and metformin treatment: a longitudinal, placebocontrolled study' . 2 The included participants with polycystic ovary syndrome (PCOS) were a sub-sample from two randomised, placebo-controlled, double-blind, multicentre trials investigating the effect of metformin treatment on pregnancy outcomes in PCOS, the PregMet 3 and PregMet2 4 trials.…”