Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study

Tylavsky, Frances A.; Kocak, Mehmet; Murphy, Laura E.; Graff, J. Carolyn; Palmer, Frederick B.; Völgyi, Eszter; Diaz-Thomas, Alicia; Ferry, Robert J.

doi:10.3390/nu7125499

Cited by 52 publications

(47 citation statements)

References 52 publications

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“…Participants were enrolled in the Conditions Affecting Neurocognitive Development in Early Childhood (CANDLE) study, a prospective prenatal cohort in Memphis, Tennessee. Briefly, 1503 healthy women, 16‐40 years of age, with a singleton pregnancy, and intent to deliver at a study hospital were enrolled during 16‐28 weeks estimated gestational age (EGA) from community‐based obstetric practices between 2006 and 2011 . The CANDLE study included 2nd and 3rd trimester and delivery visits during which we obtained demographics, psychosocial and medical histories, and biospecimens.…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, 1503 healthy women, 16-40 years of age, with a singleton pregnancy, and intent to deliver at a study hospital were enrolled during 16-28 weeks estimated gestational age (EGA) from community-based obstetric practices between 2006 and 2011. 18,19 The CANDLE study included 2nd and 3rd trimester and delivery visits during which we obtained demographics, psychosocial and medical histories, and biospecimens. Mother-child dyads were followed with in-person study visits annually.…”

Section: Study Populationmentioning

confidence: 99%

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Association of prenatal folate status with early childhood wheeze and atopic dermatitis

Roy

Kocak

Hartman

et al. 2017

Pediatric Allergy Immunology

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Background Prenatal folic acid supplementation is recommended to prevent birth defects. Some foods are fortified in the U.S. to ensure sufficient intake among reproductive-aged women. However, high prenatal folate exposure may be a risk factor for childhood atopic diseases. We investigated associations between prenatal folate and early childhood wheeze and atopic dermatitis in a U.S. cohort. Methods We studied 858 mother-child dyads, enrolled prenatally. Folate was measured in 2nd and 3rd trimester maternal plasma. Parents reported current wheeze (previous 12 months) and healthcare provider diagnosis of atopic dermatitis at 3 years. We examined associations using logistic regression, modeling folate continuously and dichotomously (< or ≥20 ng/ml), a level often considered supraphysiologic. Results Over half of women were African-American and on Medicaid. Median (interquartile range) folate levels were 22.6 (15.9–30.0) and 23.1 (16.1–30.0) ng/mL for 2nd and 3rd trimesters, respectively. Current wheeze and atopic dermatitis were reported for 20.4% and 26.8% of children, respectively. Second trimester folate as a continuous exposure was not significantly associated with outcomes. Decreased odds of current wheeze was observed in children born to mothers who had 2nd trimester folate ≥ 20 ng/mL (adjusted odds ratios = 0.67, 95% confidence interval = 0.46, 0.97) compared to children with maternal levels < 20 ng/mL. Third trimester folate was not associated with outcomes. Conclusions High plasma folate in mid-pregnancy was associated with decreased odds of current wheeze at age 3. Our findings do not support harmful effects of high prenatal folate levels on childhood atopic diseases in this setting.

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Section: Methodsmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Association of prenatal folate status with early childhood wheeze and atopic dermatitis

Roy

Kocak

Hartman

et al. 2017

Pediatric Allergy Immunology

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“…Seven studies did not find any association between prenatal vitamin D levels and global IQ or cognitive development at preschool [69][70][71][72] and school age [73,74]. However, Keim et al [75] reported a positive association between both maternal and cord blood 25(OH)D concentration and IQ at age 7, but the effect estimates were very small.…”

Section: Global Intelligence Quotient (Iq) or Cognitive Developmentmentioning

confidence: 99%

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Larqué

Morales

Leis³

et al. 2018

Ann Nutr Metab

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Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH]D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Summary: The foetus depends fully on maternal 25(OH)D supply. 25(OH)D readily crosses the placenta and it is activated into 1,25(OH)₂D by foetal kidneys. Moreover, 1,25(OH)₂D can also be synthesized within the placenta to regulate placental metabolism. The importance of vitamin D during pregnancy for maintaining maternal calcium homeostasis and therefore for foetal bone development is well recognized; major discussions are in progress regarding the potential maternal detrimental effects on pregnancy outcomes, foetal development, and the long-term health of children. Interventional studies have also evaluated the effect of vitamin D for reduction on preterm birth and asthma programming. Key Messages: Clinically, by understanding the effects of vitamin D on perinatal outcomes, we could individualize antenatal counselling regarding vitamin D supplementation to ensure vitamin D repletion without increasing the risk of foetal hypercalcemia.

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“…A growing body of evidence suggests that low maternal 25(OH)D levels during pregnancy are associated with impaired neurodevelopmental and neurocognitive outcomes during infancy and childhood [117,[224][225][226][227][228]; however, not all studies are in agreement [229,230]. In this regard, several studies have shown a significant association between suboptimal maternal vitamin D status and reduced language developmental outcomes in the offspring [224][225][226].…”

Section: Offspring Brain Development and Functionmentioning

confidence: 99%

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Keshavarz¹,

Jandaghi²,

Shafiee³

et al. 2020

Vitamin D Deficiency

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Maternal vitamin D deficiency in pregnancy is a widespread public health concern. Race and ethnicity as biological and cultural factors, respectively, can affect vitamin D status through differences in skin color, sunlight exposure, and dietary intake. Low maternal vitamin D status in pregnancy may affect both mother and fetus adversely. Vitamin D deficiency and insufficiency are linked to a wide variety of adverse pregnancy outcomes such as gestational diabetes, preeclampsia, and preterm delivery. Furthermore, maternal vitamin D deficiency has been linked to several adverse health outcomes in infants and children. The examples include, but not limited to, impaired growth, skeletal problems, and autoimmune diseases such as type 1 diabetes and asthma. This chapter reviews the vitamin D status during pregnancy across different ethnic groups, looking into the adverse pregnancy and child outcomes, followed by a discussion on the association between maternal and child vitamin D status and successful interventions. Strong evidence exists about the association between vitamin D and some health outcomes during pregnancy, while more studies are needed to confirm the other claim. The existing body of evidence justifies the need for well-designed policies and systematic interventions to ensure optimal vitamin D status of pregnant women and their offsprings across different ethnic and racial groups.

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Gestational Vitamin 25(OH)D Status as a Risk Factor for Receptive Language Development: A 24-Month, Longitudinal, Observational Study

Cited by 52 publications

References 52 publications

Association of prenatal folate status with early childhood wheeze and atopic dermatitis

Association of prenatal folate status with early childhood wheeze and atopic dermatitis

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

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