Gestational Trophoblastic Neoplasia

Osborne, R.; Dodge, Jason

doi:10.1016/j.ogc.2012.03.002

Cited by 18 publications

(13 citation statements)

References 59 publications

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“…The reason for surgical intervention in this study is correlated to previous reviews (Lurain et al, 1995;Patel et al, 2010;Rodriguez et al, 2010). Multimodality treatment can improve overall survival of resistant GTN patients (Lurain, 2011;Osborne et al, 2012).…”

Section: Discussionsupporting

confidence: 78%

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Treatment of Extremely High Risk and Resistant Gestational Trophoblastic Neoplasia Patients in King Chulalongkorn Memorial Hospital

Oranratanaphan

Lertkhachonsuk²

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 78%

“…Shina Oranratanaphan*, Ruangsak Lertkhachonsuk risk factor scoring system (Hertz et al, 1956;Lurain et al, 1995;Osborne et al, 2012). Criteria for diagnosis of postmolar GTN include at least 1 of the followings .…”

Section: Treatment Of Extremely High Risk and Resistant Gestational Tmentioning

confidence: 99%

Treatment of Extremely High Risk and Resistant Gestational Trophoblastic Neoplasia Patients in King Chulalongkorn Memorial Hospital

Oranratanaphan

Lertkhachonsuk²

2014

Asian Pacific Journal of Cancer Prevention

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“…About 50% of all cases of GTN occur postmolar gestations, 25% after abortions or ectopic pregnancies and 25%, after term or preterm deliveries 4 . PSTT and ETT, however, develop after term deliveries or non-molar abortions in 95% of the cases 6 . The largest epidemiological study conducted in Brazil about trophoblastic disease found that GTN developed in 24.6% of the patients that had complete hydatidiform moles and in 7.6% of the cases of partial hydatidiform moles 7 .…”

Section: Introductionmentioning

confidence: 97%

Diagnosis, classification and treatment of gestational trophoblastic neoplasia

Biscaro¹,

Braga²,

Berkowitz³

2015

Rev. Bras. Ginecol. Obstet.

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Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment. ResumoNeoplasia trofoblástica gestacional (NTG) é o termo que descreve o conjunto de anomalias malignas da placenta, incluindo a mola invasora, coriocarcinoma, tumor trofoblástico do sítio placentário e tumor trofoblástico epitelióide. Ambos a mola invasora e o coriocarcinoma respondem bem à quimioterapia, com taxas de cura superiores a 90%. Desde o advento da quimioterapia, NTG de baixo risco tem sido tratada com monoquimioterapia, pelo geral methotrexate ou actinomicina-D. Casos de NTG de alto risco, contudo, devem ser tratados com poliquimioterapia, e o regime usualmente escolhido é o EMA-CO que combina etoposide, methotrexate, actinomicina-D, ciclofosfamida e vincristina. Esse estudo revê a literatura sobre NTG a fim de discutir os conhecimentos atuais sobre seu diagnóstico e tratamento.

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“…Despite this aggressiveness, choriocarcinoma is generally highly chemosensitive and carries a much better cure rate than other comparable malignancies. Patients may present with signs and symptoms of bleeding from metastases such as hemoptysis, intraperitoneal bleeding or acute neurologic deficits [7, 8]. …”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma

Milenkovic

Lazović

Mačvanski³

et al. 2013

Case Rep Oncol

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Choriocarcinoma is the most malignant tumor of gestational trophoblastic disease arising from any gestation. It has a tendency toward relapse as well as metastasis. Here, a case of relapsed high-risk choriocarcinoma (FIGO stage IV, WHO score 12) in a 37-year-old female presenting with vaginal bleedings is described. Relapse developed at the site of the surgical scar from hysterectomy that had been performed 2 years earlier. Although the patient was treated with aggressive chemotherapy, she was in a bad general condition and died from infection and liver insufficiency.

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Gestational Trophoblastic Neoplasia

Cited by 18 publications

References 59 publications

Treatment of Extremely High Risk and Resistant Gestational Trophoblastic Neoplasia Patients in King Chulalongkorn Memorial Hospital

Treatment of Extremely High Risk and Resistant Gestational Trophoblastic Neoplasia Patients in King Chulalongkorn Memorial Hospital

Diagnosis, classification and treatment of gestational trophoblastic neoplasia

Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma

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