Gestational Trophoblastic Neoplasia: A Tunisian Multicenter Study

Rachdi, Haifa; Mokrani, Amina; Batti, Rim; Raies, Henda; Touhami, Omar; Ayadi, Mouna; Meddeb, K.; Letaief, Feryel; Yahiaoui, Yosra; Chraiet, Nesrine; Mézlini, Amel

doi:10.31557/apjcc.2019.4.2.59-64

Cited by 1 publication

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“…Gestational Trophoblastic disease is a continuum, which covers a wide range of states from benign molar pregnancy to Gestational Trophoblastic Neoplasia (GTN) Rachdi et al, 2019). Molar pregnancy is divided into three categories; complete, partial, and invasive mole, and malignant form (Hurteau, 2003).…”

Section: Introductionmentioning

confidence: 99%

Prophylactic Chemotherapy with Methotrexate Leucovorin in High-Risk Hydatidiform Mole

Aminimoghaddam

Mahmoudzadeh

Mohammadi

2020

Asian Pac J Cancer Prev

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Aim: Gestational Trophoblastic Neoplasia (GTN) is used to describe a group of malignant gestational tumors originating from the placenta. The chance of having malignant GTN is high in a high-risk molar pregnancy. The main aim of this study is to investigate the effectiveness of using prophylactic chemotherapy in high-risk molar pregnancy to prevent malignant GTN. Method: In this case-control retrospective study, all patients with high-risk mole referred to Firoozgar and Akbarabadi Hospitals affiliated with Iran University of Medical Sciences (IUMS) from 2003 to 2013 were divided into two groups of recipient and non-recipient of methotrexate prophylactic chemotherapy.Demographic information including age, parity, weight, serum βHCG before and after the intervention, level of liver function tests (LFT) and GTN were analyzed. Results: There were 102 patients with a mean age of 27.13 years (SD= 0.37), and 51 patients (50 %) received prophylactic Methotrexate (MTX), and others were the non-receivers. Finally, 23 patients (22.5%) were inflicted with GTN, and 79 (77.5 %) did not. The average time of βHCG spontaneous remission between the groups were 2.5 (SD=1.33) and 3.2 (SD=1.21), for the recipient and non-recipient, respectively, which showed a significant difference (p). Conclusion: This study concludes that prophylactic chemotherapy with MTX and leucovorin may be capable of reducing GTN, which supports the prescription of MTX in high-risk mole, especially in countries with limited resources. The toxicity of methotrexate can be reduced with the addition of leucovorin.

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Section: Introductionmentioning

confidence: 99%