Gestational Trophoblastic Disorders: An Update in 2015

Stevens, Franziska Teresa; Katzorke, Nora; Tempfer, Clemens B.; Kreimer, U; Bizjak, G; Fleisch, Markus; Fehm, Tanja

doi:10.1055/s-0035-1558054

Cited by 83 publications

(92 citation statements)

References 40 publications

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“…Human choriocarcinoma is one of the malignant trophoblastic cancers which usually arises as a hydatidiform mole during pregnancy (Stevens et al, ). The choriocarcinoma cells have a high capacity for vascular invasion and metastasis to lungs, brain, liver, bone, kidney, and even the pituitary gland compared to other gestational trophoblastic diseases such as invasive moles, placental site trophoblastic tumors, and epithelioid trophoblastic tumors (Liu, Xiao, Peng, Zhou, & Liu, ).…”

Section: Introductionmentioning

confidence: 99%

Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

Ham

Lim

Bazer

et al. 2017

Journal Cellular Physiology

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Silibinin is a flavonolignan extracted from seeds of milk thistles. Traditionally, it has been used as a therapeutic agent for liver disorders, and now it is well-known for its anti-cancer effects. However, studies on anti-cancer effects of silibinin on choriocarcinoma are very limited. Therefore, we performed proliferation and apoptosis assays to determine effects of silibinin on the viability of human choriocarcinoma (JAR and JEG3) cells. Our results showed that silibinin significantly inhibited proliferation and induced apoptosis in both JAR and JEG3 cells, and significantly increased reactive oxygen species (ROS) and lipid peroxidation. Moreover, silibinin disrupted mitochondrial function by inducing permeabilization of mitochondrial membrane potential and calcium ion efflux in JAR and JEG3 cells. Furthermore, silibinin-induced apoptosis in choriocarcinoma cells via AKT, mitogen-activated protein kinases (MAPK) and unfolded protein response (UPR) signal transduction. Collectively, our results suggest that silibinin is a novel therapeutic agent or dietary supplement for management of human placental choriocarcinomas.

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Section: Introductionmentioning

confidence: 99%

Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

Ham

Lim

Bazer

et al. 2017

Journal Cellular Physiology

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“…Despite not having been evaluated the presence of molar previous pregnancies, Stevens et al [14] argue that the risk of developing GTD gradually increases with the molar amount of previous pregnancies. This information reinforces the influence of genetic factors in the development of this pathology.…”

Section: Age Sex and Hereditary Factorsmentioning

confidence: 99%

Gestational Trophoblastic Disease: An Analysis Focused On Social Determinants Of Health

et al. 2016

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“…The incidence is approximately 1–3 in 1000 pregnancies for complete hydatidiform mole (CHM) and 3 in 1000 pregnancies for partial hydatidiform mole (PHM) in North America and Europe; both conditions appear to be diagnosed more often in Asia and Latin America 2, 3. Some studies show that cases are ten times more likely in some Asian or African countries 4, 5, 6.…”

Section: Introductionmentioning

confidence: 99%

“…1 The incidence is approximately 1-3 in 1000 pregnancies for complete hydatidiform mole (CHM) and 3 in 1000 pregnancies for partial hydatidiform mole (PHM) in North America and Europe; both conditions appear to be diagnosed more often in Asia and Latin America. 2,3 Some studies show that cases are ten times more likely in some Asian or African countries. [4][5][6] In Brazil, there is no official gestational trophoblastic disease registry, and this disease, despite its important morbidity and psychosocial impact, may be underestimated at 1/200-800 gestations, depending on the geographical region.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of p57^KIP² compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta‐analysis

Madi

Braga

Paganella

et al. 2018

BJOG

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BackgroundDistinguishing hydatidiform moles (HMs) from nonmolar specimens and the subclassification of HM are important because complete hydatidiform mole (CHM) is associated with an increased risk of development of gestational trophoblastic neoplasia. However, diagnosis based solely on morphology has poor inter‐observer reproducibility. Recent studies have demonstrated that the use of p57KIP 2 immunostaining improves diagnostic accuracy for CHM.ObjectivesTo evaluate the accuracy of p57KIP 2 immunostaining compared with molecular genotyping for the diagnosis of CHM.Search strategyMajor databases were searched from inception to March 2017 using the terms ‘hydatidiform mole’, ‘p57’, and ‘genotyping’, with their variations, and the search limit for the relevant study design.Selection criteriaAny cross‐sectional study, case series, case–control study, cohort study, or clinical trial that evaluated the accuracy of p57KIP 2 immunostaining for the diagnosis of CHM compared with genotyping was included. Case reports, narrative reviews, expert opinions, and animal testing were excluded.Data collection and analysisExtracted accuracy data were tabulated and pooled using a hierarchical bivariate random effects model.Main resultsBivariate meta‐analysis produced a summary sensitivity of 0.984 (95% CI: 0.916–1.000) and specificity of 0.625 (95% CI: 0.503–0.736) with significant heterogeneity for specificity (I 2 = 71.8, chi‐square P = 0.029). The pooled summary diagnostic odds ratio was 56.54 (95% CI: 11.03–289.74) with no heterogeneity (I 2 = 0.00%, chi‐square P = 0.67). The diagnostic performance of the test was high with an area under the curve of (AUC) 0.980.Conclusionsp57KIP 2 immunostaining is accurate when diagnosing CHM. It can be used as an adjunct test in a combination algorithmic approach.Tweetable abstractA meta‐analysis to evaluate the accuracy of p57KIP 2 compared with genotyping to diagnose CHM.

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Gestational Trophoblastic Disorders: An Update in 2015

Cited by 83 publications

References 40 publications

Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

Gestational Trophoblastic Disease: An Analysis Focused On Social Determinants Of Health

Accuracy of p57^KIP² compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta‐analysis

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Gestational Trophoblastic Disorders: An Update in 2015

Cited by 83 publications

References 40 publications

Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

Gestational Trophoblastic Disease: An Analysis Focused On Social Determinants Of Health

Accuracy of p57KIP2 compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta‐analysis

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Accuracy of p57^KIP² compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta‐analysis