Gestational trophoblastic disease- rare, sometimes dramatic, and what we know so far

Subcutaneous choriocarcinomas in captive Amargosa voles (Microtus californicus scirpensis)

“…The presence of paternal deoxyribonucleic acid by genotyping and short-tandem repeat analysis in these tumors are techniques used to distinguish gestational from nongestational choriocarcinomas in humans. 23 Gestational choriocarcinomas in humans are also correlated with significantly elevated levels in serum beta-gonadotropin hormone, which if available for the vole could support the proposed pathogenesis. 23 In summary, this case series documents an unusual presentation of subcutaneous choriocarcinomas in 4 Amargosa voles maintained in a breeding colony and proposes a pathogenesis of gestational disease, involving subcutaneous trophoblastic embolization and malignant transformation.…”

“…Nongestational choriocarcinomas are germ cell-derived trophoblastic tumors that rarely metastasize via the lymphatics to the lung, liver, brain, and vulvovaginal region. 13,23 While uncommon, choriocarcinomas have been reported in domestic and laboratory animals and in wildlife, including spontaneous or experimentally induced gestational choriocarcinomas in the rhesus macaque, armadillo (Dasypus novemcinctus mexicanus), and 2 rabbits. 10,12,17 Spontaneous nongestational choriocarcinomas have been described in the ovaries in 2 rhesus macaques (Macaca mulatta), a cynomolgus macaque (M. fascicularis), 6,16,24 and laboratory mouse strains, such as B6C3F1 and Crl:CD1 (ICR), and once in the testes of a Swiss albino mouse.…”

“…Gestational trophoblastic disease is a group of benign and malignant gestational tumors in which abnormal trophoblast cells grow inside the uterus after conception. 23 Choriocarcinoma is a rare subtype of gestational trophoblastic disease and can be of gestational or nongestational origin. 13,23 Gestational choriocarcinoma is derived from placental trophoblastic lineage cells, while nongestational choriocarcinoma arises from totipotential germ cells in the ovaries, testes, or midline tissues in the mediastinum or abdomen.…”

“…23 Choriocarcinoma is a rare subtype of gestational trophoblastic disease and can be of gestational or nongestational origin. 13,23 Gestational choriocarcinoma is derived from placental trophoblastic lineage cells, while nongestational choriocarcinoma arises from totipotential germ cells in the ovaries, testes, or midline tissues in the mediastinum or abdomen. 23 In humans, gestational choriocarcinoma often occurs following a molar pregnancy presenting as an abnormal overgrowth of placental chorionic tissue in the uterus (also known as hydatidiform mole), which can invade the myometrium and spread hematogenously to extrauterine sites.…”

Gigantisches Chorionkarzinom bei einer multiparen Frau in der postpartalen Periode

“…Die trophoblastischen Erkrankungen (TSE) sind eine heterogene Gruppe von Tumoren, die durch eine abnormale Trophoblastenproliferation gekennzeichnet sind. Die Morphologie und klinische Symptomatik variieren sehr stark und reichen von gutartigen Läsionen, die manchmal dysfunktionale Uterusblutungen verursachen, bis hin zur aggressiven Malignomen [1,2]. Trophoblastentumoren sind immer mit einer Schwangerschaft assoziiert und können sich sowohl während der Schwangerschaft als auch nach ihrer Beendigung (von einigen Tagen bis zu mehreren Jahren) manifestieren.…”