Gestational Trophoblastic Disease

Soper, John T.

doi:10.1097/aog.0000000000004240

Cited by 83 publications

(33 citation statements)

References 68 publications

(84 reference statements)

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“…Choriocarcinoma can be gestational or nongestational, all the 36 patients treated in our department from March 2013 to September 2020 were diagnosed as gestational choriocarcinoma. The morbidity of gestational choriocarcinoma ranged from 1 to 9.3 in 40,000 pregnancies from data of different areas [11,12]. One of the most important prognostic factors of choriocarcinoma patients is chemotherapy sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases

Liu¹,

Chen²,

Zhu³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: Choriocarcinoma is a curable malignant neoplasm when chemotherapy is properly implemented. However, when chemotherapy resistance occurs, disease can be fatal. Misdiagnosis is common, which may lead to delaying of the first cycle of chemotherapy and increase the possibility of chemoresistance. Methods: We analyzed 36 choriocarcinoma cases who were treated in our department about their clinical characteristics, and their diagnosis and treatment processes together with the serum β-hCG variation. Results: Analysis showed that the disease onset age, FIGO (International Federation of Gynecology and Obstetrics) stage distribution were similar to the other cohort. The primary origins were uterine canals, and the serum β-hCG elevated with or without vaginal bleeding were common, which all easily lead to misdiagnosis of benign pregnancy related diseases. Our data demonstrated that the misdiagnosis of choriocarcinoma resulted in delaying of the first cycle of chemotherapy, followed by decreased control of serum β-hCG after one chemotherapy cycle and more cycles for serum β-hCG normalization, which meant the possibility of generating chemoresistance. Conclusions: In summary, standardized surveillance and treatment process to decrease misdiagnosis rate of choriocarcinoma can be an effective measure to improve the prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases

Liu¹,

Chen²,

Zhu³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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“…Las pacientes con puntuaciones de riesgo FIGO de 13 o más tienen mayor riesgo de mortalidad cuando se las trata inicialmente con terapia con agentes múltiples. Estas pacientes pueden desarrollar una respuesta tumoral masiva inicial, con síndrome de lisis tumoral, hemorragia catastrófica de sitios metastásicos, falla orgánica múltiple, mielosupresión y sepsis (13) .…”

Section: Discussionunclassified

Enfermedad trofoblástica gestacional en el posparto tardío

Vega¹,

Martino²,

Qureshey³

2021

Rev peru ginecol obstet.

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La enfermedad trofoblástica gestacional (ETG) es un término utilizado para un grupo de tumores relacionados con el embarazo que surgen de la proliferación defectuosa del tejido trofoblástico. Su incidencia después de un embarazo a término no es frecuente, siendo diagnosticada en la mayoría de los casos de forma incidental, por síntomas de metástasis. Presentamos un caso de ETG que ocurrió 9 semanas después de un parto vaginal a término. El nivel sérico de gonadotropina coriónica humana beta (hCG-β) fue de 38 084 mUI/mL y una tomografía de tórax mostró múltiples nódulos pulmonares. La paciente recibió actinomicina D durante 3 ciclos. La hCG-β se normalizó después del tercer ciclo y la paciente permaneció libre de enfermedad durante 12 meses después del diagnóstico. Se describe la presentación clínica y los desafíos en el diagnóstico de ETG en el período posparto tardío.

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“…pacienčių. Rizika komplikacijoms išsivystyti išauga, jeigu gimda yra didesnė negu turėtų būti 14-16 gestacinę savaitę [6]. Komplikacijos: hipertenzija, hipertiroidizmas, anemija, hyperemesis gravidarum (nėštumo metu sukeltas stiprus pykinimas ir vėmimas), respiracinis distresas [1].…”

Section: Trofoblastinės Ligos Klinikaunclassified

Trophoblastic Disease: Review of the Literature

Launikonytė

Korsakaitė

Bužinskienė

2022

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The purpose of this literature review is to discuss the most effective gestational trophoblastic disease diagnostic and treatment methods. Also, to introduce some of the novel treatment options currently being explored. A comprehensive research was carried out on scientific databases of MEDLINE and PubMed over the time period of 2014 to 2021. According to literature sources initial gestational trophoblastic disease diagnosis is multimodal: encompassing clinical features, quantitative human chorionic gonadotropin titers and pelvic ultrasonography. Pelvic magnetic resonance imaging, body computed tomography, chest radiography and angiography are the methods usually used for overall disease staging and metastases detection. The best treatment method is designated with reference to individual features of the patient and the disease. Conventional treatment consists of hysterectomy and chemotherapy; however, the use of new methods, such as directed enzyme prodrug therapy is also being attempted to cure metastasized and/or resistant gestational trophoblastic neoplasias. Most women with gestational trophoblastic disease can be successfully managed with preservation of reproductive function due to early diagnosis in the first trimester of pregnancy. It is important to identify gestational trophoblastic disease promptly and adjust specific treatment for every patient properly to minimize various complications.

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Gestational Trophoblastic Disease

Cited by 83 publications

References 68 publications

Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases

Misdiagnosis and Chemotherapy Delaying Reduces the Chemosensitivity of Choriocarcinoma Patient: Analysis of 36 Cases

Enfermedad trofoblástica gestacional en el posparto tardío

Trophoblastic Disease: Review of the Literature

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