Gestational Trophoblastic Disease at Sultan Qaboos University Hospital: Prevalence, Risk Factors, Histological Features, Sonographic Findings, and Outcomes

Abstract

Objectives We sought to assess the prevalence of gestational trophoblastic diseases (GTD) among pregnant women at Sultan Qaboos University Hospital (SQUH) and compare our results with the international studies. We also sought to determine the risk factors, histological features, sonographic findings, and outcomes in women with GTD. Methods We conducted a retrospective cohort study of all women diagnosed with GTD and followed at SQUH between November 2007 and October 2015. We collected data on maternal demographics, risk factors, sonographic features, histological diagnosis, follow-up period, and chemotherapy treatment from the hospital information system. Results Sixty-four women with GTD were included in the study with a mean age of 31.0±7.5 years, mean gravidity 4.0, and parity 2.0. The prevalence of GTD was 0.3% (one in 386 births), and the most common risk factors were increased maternal age and multiparity. A partial hydatidiform mole was diagnosed in 54.7%, complete hydatidiform mole in 43.8%, and invasive mole in 1.6% of women. Eleven percent of women required chemotherapy. Typical ultrasound features for partial molar pregnancy were present in 54.7% of our sample, while snowstorm appearance was seen in 89.3% of those with complete mole. Negative beta-human chorionic gonadotropin was achieved 70 days after diagnosis in 41 women. Conclusions The awareness of the risks and complications of GTD among physicians with close follow-up is paramount. There is a need to establish a national registry of GTD cases in Oman.

Ten-Year Review of Gestational Trophoblastic Disease at Lady Reading Hospital, Peshawar

“…Regarding the type of lesion in this study, complete moles were most frequent (65.2%). A similar study in Nigeria reported 57.34% complete mole [12], and in another seven-year study in Oman complete hydatidiform mole was reported in 43.8% [14]. However, in our study the second most frequent lesion was invasive mole (20.4%), which is higher than reported in similar regional and international studies (1.46%, 2.7%, 2.56% and 12.5%) [15][16][17][18].…”

“…Age analysis in this study revealed that overall, most patients were between 21-30 years of age (41.4%). Related studies in Pakistan and India showed the same age group to have a high prevalence (54.54% and 66%), however international studies reported a high prevalence in 31-40 years of age [14][15][16][17][18]. This is an important finding which shows that a much younger population is affected in this part of the world.…”

Enfermedad Trofoblástica Gestacional: Reporte de un Caso

“…En la mola completa la imagen típica de "copos de nieve" o "panal de abejas" se manifiesta por la cavidad ocupada por ecos disminuidos en amplitud, que corresponden al tejido trofoblástico proliferado [9]. Dentro de los estudios de laboratorio la determinación cuantitativa de la subunidad beta de hCG con valores elevados [10], el estudios histopatológicos tiene una apariencia típica de una masa voluminosa de estructuras de vellosidad coriónica anormales se lo utiliza como el método confirmatorio [11]. El legrado aspirativo previa dilatación cervical mecánica y bajo guía ecográfica es el método de preferencia.…”

Profil dan Karakteristik Penderita Tumor Trofoblas Gestasional di RSUP Dr. Hasan Sadikin Periode 2021

“…Pada penelitian di RS Pendidikan Universitas Sultan Qaboos disimpulkan bahwa riwayat multiparitas menjadi salah satu faktor risiko yang signifikan terhadap pembentukan TTG. 13 Pada Huanca-Llamo dkk. dalam uji bivariat disimpulkan bahwa abortus (OR 6,54; 95% CI 3,12 -13,74; p <0,001) dan multiparitas (OR 3,35; CI 95%: 1,47 -7,65; p <0,001) signifikan menjadi faktor risiko PTG.…”