Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes

Lesseur, Corina; Jessel, Rebecca H.; Ohrn, Sophie; Ma, Yula; Li, Qian; Dekio, Fumiko; Brody, Rachel; Wetmur, James G.; Gigase, Frederieke; Lieber, Molly; Lieb, Whitney; Lynch, Jezelle; Afzal, Omara; Ibroci, Erona; Rommel, Anna‐Sophie; Janević, Teresa; Stone, Joanne; Howell, Elizabeth A.; Galang, Romeo R.; Dolan, Siobhan M.; Witte, Lotje D. De; Chen, Jia

doi:10.1016/j.placenta.2022.06.017

Cited by 7 publications

(8 citation statements)

References 72 publications

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“…No differences were found in expression levels of transmembrane protease serine 2 (TMPRSS2) [ 31 ] in infected compared to SARS-CoV-2 negative controls. Infection was reported to be associated with decreased levels of the protease furin in one study [ 28 ] while another found no differences in infected compared to SARS-CoV-2 negative controls [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…Single cell RNA sequencing (scRNAseq) analysis demonstrated impaired trophoblast differentiation and lowered expression of syncytiotrophoblast related genes [ 19 ]. SARS-CoV-2 infection was associated with decreased levels of trophoblast cell type markers pregnancy specific beta-1-glycoprotein 3 (PSG3), and chorionic gonadotropin subunit beta 3 (CGB3) [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…This is likely due to when participants are most likely to receive testing, such as through routine hospital screening at presentation for delivery. Given the contradictions in the literature to date, in that some authors suggest timing of infection does not impact placental pathology [ 28 , 72 ], while others report the risk of developing some placental pathologies, particularly FVM, differs based on timing of infection [ 73 ], further research in regard to gestational age and infection is required. In addition, further research is needed to investigate whether SARS-CoV-2 infections earlier in pregnancy have a greater impact on placentation and RAS-mediated trophoblast invasion.…”

Section: Considerations For Future Researchmentioning

confidence: 99%

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Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection—A scoping review

et al. 2023

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Background Emerging evidence suggests that SARS-CoV-2 infection during pregnancy can result in placental damage and poor placental outcomes. However, the mechanisms by which SARS-CoV-2 infection leads to placental damage are not well understood. With a rapid expansion of literature on this topic, it is critical to assess the quality and synthesize the current state of literature. The objective of this scoping review is to highlight underlying mechanisms of SARS-CoV-2 mediated placental pathology in pregnant individuals and identify literature gaps regarding molecular and cellular mechanisms of poor placental outcomes. Methods The review was conducted and reported following the recommendations of the PRISMA extension for Scoping Reviews. The study protocol was registered with Open Science Framework (https://osf.io/p563s/). Five databases (MEDLINE, EMBASE, Scopus, CINAHL, PubMed) were searched for studies published between September 2019 until April 2022. Studies assessing placental outcomes with respect to SARS-CoV-2 infection in pregnancy were eligible for inclusion. Outcomes of interest included histopathology, and molecular or cellular analysis. All records were uploaded into Covidence and extracted using the Joanna Briggs Institute method. Studies were assessed for risk of bias using the Newcastle Ottawa scale and a narrative synthesis of results was generated. Results Twenty-seven studies reporting on molecular and/or cellular mechanisms of SARS-CoV-2 mediated placental outcomes were included in this review. SARS-CoV-2 infection was associated with perturbations in the ACE2 pathway, inflammatory mediators and immune cell populations and mitochondrial function in placentas. Conclusions Our findings suggest that changes in the ACE2 pathway, mitochondrial dysfunction, and/or inflammatory processes may lead to placental damage observed in SARS-CoV-2 infection during pregnancy. More research is needed to understand the role of these pathways further, in addition to data collection related to trimester, severity, and strain.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Considerations For Future Researchmentioning

confidence: 99%

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Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection—A scoping review

et al. 2023

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“…The confirmation of our results would clarify the effect of SARS-CoV-2 infection in placenta tissues. Interestingly, placenta samples delivered from SARS-CoV-2 positive subjects showed a decreased expression of two trophoblast genes (PSG3, with immunoregulatory and angiogenic functions and CGB3, essential for pregnancy maintenance) and increased expression of three immune genes (CXCL10, pro-inflammatory chemokine secreted in response to interferon gamma, TLR3 and DDX58, involved in recognizing double-stranded RNA) [ 35 ]. These data support our data and the role of SARS-CoV-2 infection in modifying immune and trophoblast gene expression [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of SARS-CoV-2 infection in pregnancy on CD147, ACE2 and HLA-G expression

Schiuma¹,

Beltrami²,

Santi³

et al. 2023

Placenta

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“…The Gen C cohort study was established in April 2020 to investigate the effects of SARS-CoV-2 infection during pregnancy on birth outcomes as described in detail previously ( Janevic et al, 2022 ; Lesseur et al, 2022 ; Molenaar et al, 2022 ). This cohort recruited 3121 pregnant participants in NYC from the Mount Sinai Health System (MSHS) between April 20, 2020 and February 24, 2022.…”

Section: Methodsmentioning

confidence: 99%

Cross-sectional associations of maternal PFAS exposure on SARS-CoV-2 IgG antibody levels during pregnancy

Kaur

Lesseur

Chen

et al. 2023

Environmental Research

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Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes

Cited by 7 publications

References 72 publications

Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection—A scoping review

Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection—A scoping review

Effect of SARS-CoV-2 infection in pregnancy on CD147, ACE2 and HLA-G expression

Cross-sectional associations of maternal PFAS exposure on SARS-CoV-2 IgG antibody levels during pregnancy

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