Gestational Nicotine Exposure Attenuates Nicotine-Stimulated Dopamine Release in the Nucleus Accumbens Shell of Adolescent Lewis Rats

Kane, Victoria B; Fu, Yongjian; Matta, Shannon G.; Sharp, Burt M.

doi:10.1124/jpet.103.059899

Cited by 62 publications

(64 citation statements)

References 29 publications

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“…However, Shacka et al (1997) found that the same nicotine challenge dose only increased activity in 14-day old male rats prenatally exposed to nicotine. These findings are interesting in light of studies showing reduced activity of cholinergic and catecholaminergic systems in rats prenatally exposed to nicotine, an effect one might expect to influence nicotineinduced locomotor activity (Kane et al 2004;Slikker et al 2005;Slotkin 1998). The discrepancy between studies may be due to differences in the postnatal time point at which nicotine-induced locomotor behavior was measured, since neuropharmacological sequelae of prenatal nicotine exposure are known to vary over the course of postnatal development.…”

Section: Discussionmentioning

confidence: 90%

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

LeSage

Gustaf

Dufek

et al. 2006

Pharmacology Biochemistry and Behavior

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Maternal tobacco use is associated with adverse developmental outcomes in offspring, including hyperactivity. Animal studies attempting to model this phenomenon have primarily used continuous s.c. nicotine infusion as the method of nicotine administration, which does not model the intermittent bolus delivery of nicotine associated with smoking in humans. The purpose of the present experiment was to examine the locomotor activity of pre-weanling offspring of pregnant rats exposed to an i.v. nicotine dosing protocol that approximates the pattern of nicotine exposure in moderate to heavy smokers. Pregnant rats were administered an i.v. bolus of 0.03 mg/kg nicotine (N=13) or saline (N=10) every 14 min for 16 hr/day, resulting in a total daily dose of 2 mg/kg (base), from gestational day 4 to delivery. Pups from each litter were tested for spontaneous locomotor activity on postnatal days (PND) 19-21 and nicotine-induced locomotor activity on PND 22. Mean birth weight was significantly lower in nicotine-exposed pups compared to controls, but body weights were equivalent between groups by the time of behavioral testing. Mean total distance traveled, vertical counts, and stereotypy counts were lower on PND 19 in nicotine-exposed pups compared to controls, but only the difference in mean stereotypy counts was statistically significant. Within session analysis revealed that both distance traveled and stereotypy were significantly decreased in nicotine-exposed pups in the first five minutes of the session on PND 19. Total time spent in the center of the field was also lower in nicotine exposed pups. Nicotine-induced increases in activity on PND 22 did not differ according to gestational exposure. These findings demonstrate that prenatal nicotine exposure in a model that mimics the pattern of nicotine exposure from cigarette smoking in humans results in offspring that exhibit low birth weight and hypoactivity in a novel environment.

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Section: Discussionmentioning

confidence: 90%

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

LeSage

Gustaf

Dufek

et al. 2006

Pharmacology Biochemistry and Behavior

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“…Nicotinic receptors are abundant on dopamine terminals, particularly in the striatal regions, leading to the vulnerability of these cells to the toxic effects of nicotine [15]. Research has shown that prenatal administration of nicotine decreases the sensitivity of dopaminergic cells in the nucleus accumbens to administration of acute doses of nicotine later in life, indicating that these cells required higher levels of stimulation to instigate dopamine release [43]. Furthermore, both cell numbers and transcription rates of nicotinic receptors in dopaminergic cells of the ventral tegmental area (VTA) are reduced following prenatal nicotine administration, affecting dopaminergic action in both the VTA and its target regions including the nucleus accumbens and prefrontal cortex through adolescence [44].…”

Section: Discussionmentioning

confidence: 99%

Direct and Passive Prenatal Nicotine Exposure and the Development of Externalizing Psychopathology

Gatzke‐Kopp

Beauchaine

2007

Child Psychiatry Hum Dev

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The association between maternal smoking during pregnancy and childhood antisocial outcomes has been demonstrated repeatedly across a variety of outcomes. Yet debate continues as to whether this association reflects a direct programming effect of nicotine on fetal brain development, or a phenotypic indicator of heritable liability passed from mother to child. In the current study, we examine relations between maternal smoking and child behavior among 133 women and their 7-15-year-olds, who were recruited for clinical levels of psychopathology. In order to disentangle correlates of maternal smoking, women who smoked during pregnancy were compared with (a) those who did not smoke, and (b) those who did not smoke but experienced significant second-hand exposure. Second-hand exposure was associated with increased externalizing psychopathology in participant mothers' offspring. Moreover, regression analyses indicated that smoke exposure during pregnancy predicted conduct disorder symptoms, over and above the effects of income, parental antisocial tendencies, prematurity, birth weight, and poor parenting practices. This is the first study to extend the findings of externalizing vulnerability to second hand smoke exposure.

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“…Moreover, another study using double our prenatal concentration of dexamethasone in the drinking water made a detailed analysis of maternal behavior in the first week after birth and reported a positive rather than negative effect (Hauser et al, 2006). It would also appear that cross-fostering per se may not be without significant effects on maternal behaviors (Maccari et al, 1995) and has been reported to reduce baseline and nicotine-stimulated DA secretion in the nucleus accumbens (Kane et al, 2004). On the other hand, certain programming effects of prenatal dexamethasone treatment were unaffected by cross-fostering to control dams, suggesting that the GC effects operate directly in the fetus (Nyirenda et al, 2001).…”

Section: Dexamethasone Treatment Regimensmentioning

confidence: 99%

The Size and Distribution of Midbrain Dopaminergic Populations are Permanently Altered by Perinatal Glucocorticoid Exposure in a Sex- Region- and Time-Specific Manner

McArthur

McHale

Gillies

2006

Neuropsychopharmacol

110

106

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Central dopaminergic (DA) systems appear to be particularly vulnerable to disruption by exposure to stressors in early life, but the underlying mechanisms are poorly understood. As endogenous glucocorticoids (GCs) are implicated in other aspects of neurobiological programming, this study aimed to characterize the effects of perinatal GC exposure on the cytoarchitecture of DA populations in the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA). Dexamethasone was administered non-invasively to rat pups via the mothers' drinking water during embryonic days 16-19 or postnatal days 1-7, with a total oral intake circa 0.075 or 0.15 mg/ kg/day, respectively; controls received normal drinking water. Analysis of tyrosine hydroxylase-immunoreactive cell counts and regional volumes in adult offspring identified notable sex differences in the shape and volume of the SNc and VTA, as well as the topographical organization and size of the DA populations. Perinatal GC treatments increased the DA population size and altered the shape of the SNc and VTA as well as the organization of the DA neurons by expanding and/or shifting them in a caudal direction. This response was sexually dimorphic and included a feminization or demasculinization of the three-dimensional cytoarchitecture in males, and subtle differences that were dependent on the window of exposure. These findings demonstrate that inappropriate perinatal exposure to GCs have enduring effects on the organization of midbrain DA systems that are critically important for normal brain function throughout life.

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Gestational Nicotine Exposure Attenuates Nicotine-Stimulated Dopamine Release in the Nucleus Accumbens Shell of Adolescent Lewis Rats

Cited by 62 publications

References 29 publications

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats

Direct and Passive Prenatal Nicotine Exposure and the Development of Externalizing Psychopathology

The Size and Distribution of Midbrain Dopaminergic Populations are Permanently Altered by Perinatal Glucocorticoid Exposure in a Sex- Region- and Time-Specific Manner

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