Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins

Bo, Simona; Lezo, Antonela; Menato, Guido; Gallo, Martina; Bardelli, C; Signorile, Anna; Berutti, Carlo; Massobrio, M; Pagano, G

doi:10.1016/j.nut.2004.05.022

Cited by 76 publications

(84 citation statements)

References 21 publications

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“…Third, studies used different diagnostic criteria for GDM, with no clear pattern emerging regarding whether a significant association could be detected using less or more strict criteria. Some studies showed a gradient in dietary intake (e.g., increasing dietary fat intake) from normal glucose tolerance to abnormal glucose tolerance and GDM (39)(40)(41), whereas other studies found an association or no association consistent with both outcomes (16,20,42). Finally, the observed associations may be explained by residual confounding from unmeasured factors in the individual studies.…”

Section: Discussionmentioning

confidence: 96%

The Role of Energy, Nutrients, Foods, and Dietary Patterns in the Development of Gestational Diabetes Mellitus: A Systematic Review of Observational Studies

et al. 2015

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OBJECTIVEDiet may influence the risk of gestational diabetes mellitus (GDM), but inconsistent findings have been reported. The purpose of this study was to synthesize evidence from observational studies on the associations between dietary factors and GDM. RESEARCH DESIGN AND METHODSMedline and Embase were searched for articles published until January 2015. We included observational studies of reproductive-aged women that reported on associations of maternal dietary intake before or during pregnancy, including energy, nutrients, foods, and dietary patterns, with GDM. All relevant results were extracted from each article. The number of comparable studies that adjusted for confounders was insufficient to perform a meta-analysis. RESULTSThe systematic review included 34 articles comprising 21 individual studies (10 prospective cohort, 6 cross-sectional, and 5 case-control). A limited number of prospective cohort studies adjusting for confounders indicated associations with a higher risk of GDM for replacing 1-5% of energy from carbohydrates with fat and for high consumption of cholesterol ( ‡300 mg/day), heme iron ( ‡1.1 mg/day), red and processed meat (increment of 1 serving/day), and eggs ( ‡7 per week). A dietary pattern rich in fruit, vegetables, whole grains, and fish and low in red and processed meat, refined grains, and high-fat dairy was found to be beneficial. The current evidence is based on a limited number of studies that are heterogeneous in design, exposure, and outcome measures. CONCLUSIONSThe findings support current dietary guidelines to limit consumption of foods containing saturated fat and cholesterol, such as processed meat and eggs, as part of an overall balanced diet. Further large prospective studies are warranted.Gestational diabetes mellitus (GDM), defined as glucose intolerance with onset or first recognition during pregnancy (1), is a common pregnancy complication affecting ;7% of pregnancies (1,2). During the past 20 years, its prevalence has increased substantially across a range of multiethnic populations and is expected to continue

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Section: Discussionmentioning

confidence: 96%

The Role of Energy, Nutrients, Foods, and Dietary Patterns in the Development of Gestational Diabetes Mellitus: A Systematic Review of Observational Studies

et al. 2015

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“…For example, selenium and zinc are involved in glucose homeostasis. In humans, dietary intakes and serum concentrations of both elements were inversely associated with occurrence of gestational diabetes mellitus (GDM) [39]. Furthermore, significantly decreased serum selenium and zinc and-at the same timepositive correlation between them were observed in pregnant women with a secondtrimester termination due to fetal neural tube defects [40].…”

Section: Discussionmentioning

confidence: 99%

Iodine, Selenium, and Other Trace Elements in Urine of Pregnant Women

Szybiński

Walas

Zagrodzki

et al. 2010

Biol Trace Elem Res

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The purpose of this work was to determine trace element levels in urine and evaluate possible associations between urinary iodine concentration (UIC), other trace elements (Cr, Cu, Fe, Mn, Na, Se, Zn), toxic elements (Cd, Pb), anthropometrical measures (body weight and height), glycemic indices (serum insulin and glucose), and several parameters related to thyroid function (thyroid stimulating hormone, free thyroxine, antithyroid peroxidase antibodies, thyroid volume, and thyroid echogenicity) in pregnant women. One hundred sixty-nine participants were recruited. The whole study group, originating from Krakow region, comprised three subgroups belonging to three trimesters: I trimester (n = 28), II trimester (n = 83), and III trimester (n = 58). Trace elements were determined using inductively coupled plasma mass/(atomic emission) spectrometry. Partial least square model was used to reveal correlation structure between parameters investigated, as well as a possible causal relationship between dependent parameters and potentially explanatory parameters. Results obtained for trace and toxic elements in urine were comparable with results of other authors, although the study group was not homogenous. We confirmed (1) low iodine excretion in pregnant women, (2) the existence of statistically significant correlation between UIC and urinary selenium, and (3) lack of correlation between latter parameter and typical indices of thyroid function. Urinary selenium correlated with other urinary trace elements, but physiological significance of this finding remains uncertain. The fact that a large number of pregnant women fail to meet dietary recommendations for iodine is the major reason for concern.

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“…Selenium must be taken daily in certain amounts in gestational periods. Dietary intakes of selenium is not the only determinant of their serum levels; other factors such as oxidative stress, age, increased elimination rate, chronic illness or inflammation, and drugs might influence their levels [3]. In general, selenium is not taken enough during gestation, which can cause selenium deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…It is like type 2 diabetes and carries risk for the mother and the fetus, and high blood glucose levels are harmful to developing child and must be carefully managed. Gestational hyperglycemia induces oxidative stress in the mother and the fetus that may be correlated to adverse fetal outcomes (fetal distress, macrosomia, or other congenital anomalies) [2,3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

Kılınç

Güven

Ezer

et al. 2008

Biol Trace Elem Res

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The aim of the study was to investigate the association between serum selenium levels in patients with gestational diabetes mellitus (GDM) and glucose intolerants and compare them with those of glucose-tolerant pregnant women. This cross-sectional study was prospectively performed in a total of 178 pregnant women undergoing a 50-g oral glucose tolerance test between 24 and 28 weeks of gestation who were grouped according to their status of glucose tolerance as with gestational diabetes (group A, abnormal 1- and 3-h glucose tolerance test; n = 30), glucose intolerant (group B, abnormal 1-h but normal 3-h glucose tolerance test; n = 47), or normal controls (group C, normal 1-h glucose test; n = 101). Serum selenium levels were measured with a graphite furnace atomic absorption spectrophotometer using a matrix modifier. Median maternal age and gestational age at the time of diagnosis in group A (gestational age = 24.8 [24-27]), group B (gestational age = 24.7 [24-27]), and group C (gestational age = 25 [24-28]) did not differ. Patients with gestational diabetes mellitus and those with glucose intolerants had lower selenium level than that of the normal pregnant women (P< 0.001). There was a significant inverse correlation between selenium and blood glucose level, and also selenium supplementation might prove beneficial on patients with GDM and prevent or retard them from secondary complications of diabetes.

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Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins

Cited by 76 publications

References 21 publications

The Role of Energy, Nutrients, Foods, and Dietary Patterns in the Development of Gestational Diabetes Mellitus: A Systematic Review of Observational Studies

The Role of Energy, Nutrients, Foods, and Dietary Patterns in the Development of Gestational Diabetes Mellitus: A Systematic Review of Observational Studies

Iodine, Selenium, and Other Trace Elements in Urine of Pregnant Women

Evaluation of Serum Selenium Levels in Turkish Women with Gestational Diabetes Mellitus, Glucose Intolerants, and Normal Controls

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