Gestational Gigantomastia Complicated by PTHrP-Mediated Hypercalcemia

Abstract

The rapid resolution of hypercalcemia after termination of pregnancy, despite persistent gigantomastia, provides evidence for a pathologic role of the placenta in the excess production of PTHrP, possibly through an as yet uncharacterized placenta-breast hormonal axis.

The Place of Reductive Surgery in the Management of Gestational Ulcerative Gigantomastia: A Case Report at Sourô Sanou Teaching Hospital

“…The probable associated risk factors are described. The disease occurs in multiparous according to some authors [2, 4, 9], rarely in nulliparous women [11]; in our case study and as reported by other authors [5, 8], it occurs in the second gravidity. White race more involved in the literature, is more an observation than just a rational explanation [12].…”

“…A report incriminates foetal activities as the genesis of the disease [9]. The best knowledge of this benign pathology helps in reassuring the patient and in initiating treatment modalities.…”

Hypercalcemia during pregnancy: management and outcomes for mother and child

“…PTHrP-induced hypercalcemia during pregnancy or lactation has also been reported, either with or without gigantomastia [28][29][30][31][32][33]. In the reported cases, associating gigantomastia and increased PTHrP serum values, hypercalcaemia was diagnosed during gestation and resolved only after mastectomy, bromocriptin administration, or termination of pregnancy [29,31,32].…”

Роль Паратгормон-Родственного Протеина В Развитии, Функционировании И Патологии Мочевыделительной И Репродуктивной Систем

“…Наличие локальной системы ПТГрП/PTH1R в маточных артериях убедительно продемонстрировано в исследовании Meziani F. et al (2008). Авторы в более ранней работе (Meziani F. et al, 2005) (2016). На 8-й неделе беременности была обнаружена фиброма матки у 26-летней женщины, которая на 14 неделе была госпитализирована с жалобами на тошноту, рвоту, запор, потерю веса и сильную артралгию в запястьях, руках, коленях и спине.…”

“…Предполагается, что источником ПТГрП в этих случаях является увеличение ткани молочной железы. (Van Heerden J.A., Gharib H., Jackson I.T., 1988; Lepre F. et al, 1993;Moazzami B. et al, 2016).…”