Gestational exposure to acrylamide inhibits mouse placental development in vivo

Maternal Exposure to Oxidized Soybean Oil Impairs Placental Development by Modulating Nutrient Transporters in a Rat Model

“…[ 44 ] Similar to some of our results, exposure to acrylamide (produced by oils during the high‐temperature process) significantly inhibited the expression of Esx1, Hand1, and Hand2, which are closely related to the vascularization and angiogenesis of the placenta. [ 38 ] Our research showed that the downregulation of the abovementioned gene mRNA in the placental OSO exposure group may lead to the collapse and atresia of the fetal blood vessels in the labyrinth layer and the disappearance of the vascular grid structure.…”

“…However, the present study showed that dietary OSO remarkably upregulated the mRNA levels of Ascl2 and Hand1, which may contribute to compensating for the downregulation of Esxl and promoting placental repair. [ 38 ] This result implied that placental retarded growth was not closely associated with the increase in Ascl2 and Hand1 in gestational rats fed OSO. The placenta clearly distinguishes three areas in the tissue structure, including the decidual layer, the sponge trophoblast cell layer, and the labyrinth trophoblast cell layer.…”

“…[ 69 ] Additionally, previous study reported that placental growth disorder and impaired fetal development may be related to the proliferation and apoptosis of placental cells. [ 38 ] To evaluate whether the fetal low birth weight and placental developmental damage exposed to OSO were related to the proliferation and apoptosis of the placenta, this study determined the expression levels of genes related to the apoptosis of the placenta. The present data showed that administration of OSO increased the mRNA level of the pro‐apoptotic gene Bax and decreased the expression of anti‐apoptotic Bcl‐2 in the placenta, which implied that dietary OSO accelerates apoptosis of the placenta.…”

“…Similar to the research of Yu et al., acrylamide, as a main toxic byproduct of oxidized frying oil, significantly inhibited the proliferation and induced apoptosis of the placenta by downregulating the expression levels of Ki67‐positive cells and Bcl‐2 protein and upregulating the levels of Bax, cleaved caspase‐3, and cleaved caspase‐8 proteins. [ 38 ] OSO exposure during pregnancy inhibited the proliferation of placental cells and induced apoptosis in pregnant rats.…”

Contaminant acrylamide in food: toxicity, detection methods, mitigation measures and risk assessment for humans

“…Meanwhile, AA can also enter the fetus or newborn through the placental barrier or breastfeeding, affecting the normal development of human offspring. Yu D et al found that AA exposure reduced the absolute and relative weights of the placenta and embryo, leading to placental atrophy, reduced number of vasa vasorum and incomplete embryonic development (D. Yu et al, 2019). AA also causes the expression of essential placental genes such as extra-embryonic tissue-spermatogenesis-homeobox gene 1 (Esx1),basic Helix-Loop-Helix (bHLH) transcription factors Hand1 and Hand2 mRNAs and induce placental cell apoptosis (Figure 4) (D. Yu et al, 2019).…”