Gestational diabetes mellitus among women attending prenatal care at Korle‐Bu Teaching Hospital, Accra, Ghana

Oppong, Samuel A.; Ntumy, Michael; Amoakoh-Coleman, Mary; Alangea, Deda Ogum; Modey-Amoah, Emefa

doi:10.1016/j.ijgo.2015.05.029

Cited by 24 publications

(45 citation statements)

References 22 publications

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“…Lower prevalence has been reported in African countries including Ghana (9.3%) [16], South African (9.1%) [21] and Nigeria (8.6%) [22] compared with developed regions like North America (12%) and Europe (14%) [2]. But Africa appears to be catching-up fast as pockets of high cases have recently been reported in Tanzania (19.5%) [23], South Africa (25.8%) [24] and Morocco (23.7%) [25].…”

Section: Discussionmentioning

confidence: 87%

“…Also, population-based prevalence from peri-urban and rural settings is unavailable. Current data on GDM in Ghana shows a prevalence of 9.3% using 2-h OGTT >8.5 mmol/l [16]. Given that this study was conducted in the largest referral/teaching hospital in Ghana where 92.5% of the study participants were urban dwellers, findings might not be representative of the typical Ghanaian population where lower population-based prevalence is hypothesized.…”

Section: Methods and Findingsmentioning

confidence: 86%

“…Traveling longer distances for emergency EmONC increases risks for complications and bad obstetric outcomes. But undoubtfully, the nutrition transition poses risk for urban dwellers [2,4,7] who are significantly more obese (4.3% vs 13.5%), have higher triglycerides (35.0% vs 64.4%) [14] and double odds for obesity [16,23].…”

Section: Discussionmentioning

confidence: 99%

“…Independent risk factors included excess intake of high glycemic index foods (aOR:2.91 95% CI]:1.05-8.06), obesity (aOR:2.13 CI:1.12-4.03), previous cesarean Introduction Gestational diabetes mellitus (GDM) is glucose intolerance that affects 1-14% of all pregnancies globally [1]. In 2017, 16.2% of live births experienced hyperglycemia in pregnancy, of which 86.4% was accountable to diabetes first recognized in pregnancy [2].…”

Section: Methods and Findingsmentioning

confidence: 99%

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Gestational diabetes using diverse diagnostic criteria, risk factors including dietary intakes, pregnancy outcomes and postpartum glycemic status: a nested case-control study in Ghana

Agbozo

Abubakari

Zotor

et al. 2019

Preprint

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Organization delivery (aOR:4.01 CI:1.08-14.76) and antenatal care in a primary facility (aOR:4.951 CI:1.87-3.76). A unit rise in blood glucose significantly increased maternal blood loss and birthweight. Adjusting for covariates, adverse birth outcomes were perineal tear (Aor:2.91 CI:1.08-5.57) and birth asphyxia (aOR:3.24 CI:1.01-10.44). Cesarean section (aOR:1.9 CI:0.97-3.68), large for gestational age (aOR:2.7 CI:0.86-5.05) and newborn resuscitation (aOR:2.91 CI 0.94-9.01) were significant at 10%. At 12 weeks postpartum, 30% of the GDM cases were unable to achieve euglycemia. Different estimates could be obtained if other diagnostic criteria were used. ConclusionsFindings show an increasing prevalence of GDM in peri-urban and rural settings highlighting the need to strengthen primary facilities to test and refer cases for management. Diet and adiposity are key risk factors necessitating lifestyle modification interventions focusing on nutrition education and weight control. GDM-exposed newborn need close monitoring as birth asphyxia which is a key outcome is likely to compromise neonatal survival. Postpartum follow-up of cases is crucial to avert transition of GDM into active diabetes.

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Section: Discussionmentioning

confidence: 87%

Section: Methods and Findingsmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Methods and Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Gestational diabetes using diverse diagnostic criteria, risk factors including dietary intakes, pregnancy outcomes and postpartum glycemic status: a nested case-control study in Ghana

Agbozo

Abubakari

Zotor

et al. 2019

Preprint

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show abstract

“…A recent review showed that merely 11% of countries had published prevalence data of GDM . Reported rates of GDM prevalence for Africa are in the range of 8.8%–9.3% . Within South Africa, varying rates of prevalence could be due to differences in population, screening practices, and diagnostic methods .…”

Section: Introductionmentioning

confidence: 99%

Maternal and neonatal outcomes following a diabetic pregnancy within the context ofHIV

Soepnel

Nicolaou

Huddle

et al. 2019

Intl J Gynecology & Obste

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Objective To characterize the demographics, comorbidities, management, and outcomes of pregnant women with pre‐gestational and gestational diabetes (GDM), including overt and true GDM, taking into account HIV infection and the influence of exposure to oral hypoglycemic agents (OHAs). Methods A review of medical records of 1071 diabetic pregnancies (between 2012 and 2018) at a tertiary hospital in South Africa. Results Of the women, 43% had GDM, 19% had type 1 diabetes (T1DM), and 38% had type 2 diabetes (T2DM). Each group had a mean initial body mass index (BMI) >25 kg/m2. Despite poor initial HbA1c for pre‐gestational groups, over 90% of the cohort achieved glycemic control by the time of delivery. The rate of prematurity was 30.9%. Perinatal mortality (PNM) was 5.1% for the pre‐gestational group and 1.8% for GDM. Of the cohort, 23.9% was HIV infected. PNM was higher in the HIV‐infected pregnancies (9.4%) than non‐HIV exposed pregnancies (1.8%, P<0.001). The macrosomia rate was higher in the glibenclamide‐exposed group than the insulin‐alone group (12.2% vs 0%, P=0.025). Conclusion Obesity is a significant predictor for macrosomia and was high in all groups. In a low‐/middle‐income country setting with a high prevalence of HIV and high usage of OHAs as an alternative to insulin therapy, HIV might be associated with higher PNM and glibenclamide with increased rates of macrosomia, which warrants further exploration.

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Prevalence and Predictors of Gestational Diabetes Mellitus in Sub‐Saharan Africa: A 10‐Year Systematic Review

Abera,

Larbie,

Abugri

et al. 2024

Endocrino Diabet & Metabol

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BackgroundGestational diabetes mellitus (GDM) remains a global public health problem, which affects the well‐being of mothers and their children in sub‐Saharan Africa (SSA). Studies conducted in different geographical areas provide varied results on its prevalence and predictors. Understanding the extent and predictors of GDM in SSA is important for developing effective interventions and policies. Thus, this review aimed to investigate the prevalence of GDM and its predictive factors in sub‐Saharan Africa.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) standards in this review. An extensive search of the PubMed, Web of Sciences and EMBASE databases was carried out covering papers from 2012 to 2022 to assess the prevalence and predictors of GDM. Microsoft Excel 2019 was utilised for study management. GraphPad Prism Version 8.0 and the MedCalc statistical software were employed for data analysis. The findings were analysed using textual descriptions, tables, forest plots and heat maps.ResultsUsing 30 studies with 23,760 participants that satisfied the inclusion criteria, the review found the overall prevalence of GDM in SSA to be 3.05% (1.85%–4.54%). History of preterm delivery, alcohol consumption, family history of diabetes, history of stillbirths, history of macrosomia, overweight or obesity and advanced mother age were all significant predictors of gestational diabetes. Additionally, various biomarkers such as haemoglobin, adiponectin, leptin, resistin, visfatin, vitamin D, triglycerides and dietary intake type were identified as significant predictors of GDM.ConclusionIn sub‐Saharan Africa, there is a high pooled prevalence of gestational diabetes mellitus. In the light of the predictors of GDM identified in this review, it is strongly recommended to implement early screening for women at risk of developing gestational diabetes during their pregnancy. This proactive approach is essential for enhancing the overall well‐being of both mothers and children.

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Gestational diabetes mellitus among women attending prenatal care at Korle‐Bu Teaching Hospital, Accra, Ghana

Abstract: GDM was found in 10% of pregnant women in Accra. Women who were obese by 20-24 weeks of pregnancy had a significantly increased risk of GDM.

Cited by 24 publications

References 22 publications

Gestational diabetes using diverse diagnostic criteria, risk factors including dietary intakes, pregnancy outcomes and postpartum glycemic status: a nested case-control study in Ghana

Gestational diabetes using diverse diagnostic criteria, risk factors including dietary intakes, pregnancy outcomes and postpartum glycemic status: a nested case-control study in Ghana

Maternal and neonatal outcomes following a diabetic pregnancy within the context ofHIV

Prevalence and Predictors of Gestational Diabetes Mellitus in Sub‐Saharan Africa: A 10‐Year Systematic Review

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