Gestational Diabetes

Sullivan, Beverly A.; Henderson, S. T.; Davis, Julie M.

doi:10.1016/s1086-5802(16)30332-1

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…To the best of our knowledge, this is the first study to determine normal ranges for a number of insulin sensitivity and resistance parameters in a sample of 115 Spanish QUICKI, Quantitative insulin sensitivity check index; IGF-I, Insulin-like growth factor-1; GH, growth hormone; HOMA, homeostatic model assessment for insulin sensitivity (-S) and resistance (-R) No significant differences were found for any parameter tested between males and females Caucasian neonates selected according to very strict criteria: term, normoweight, absence of foetal distress and mothers negative for the O'Sullivan glucose tolerance test [26]. Earlier studies [11,27,28] have shown that neonatal data (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Anthropometrical measurements were taken by trained personnel following the hospital's quality control procedures. Between weeks 24 and 28 future mothers were screened for gestational diabetes using the O'Sullivan glucose tolerance test [26], and 30% were found to be positive. The study for normal range markers was, therefore, performed on 115 neonates (54 males and 61 females).…”

Section: Protocolmentioning

confidence: 99%

“…Moreover, neonates from mothers who screen positive for gestational diabetes using the O'Sullivan glucose tolerance test [26] also show differences on glycidic metabolism parameters [12].…”

Section: Introductionmentioning

confidence: 99%

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Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Gesteiro¹,

Bastida

Sánchez‐Muniz

2008

Eur J Pediatr

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Several endocrine regulators are implicated in the development of metabolic syndrome. The aim of our study was to assess normal ranges for glucose, growth hormone (GH), insulin-like growth factor-1 (IGF-1), cortisol, insulin and the yet-to-be-published quantitative insulin sensitivity check index (QUICKI) for newborns and a number of homeostatic model assessment (HOMA)-related equations that have been proposed as indicators of insulin sensitivity (HOMA-S) and insulin resistance (HOMA-R). The study included 115 (54 males, 61 females) singleton, normoweight, Spanish Caucasian neonates delivered without foetal distress from mothers of the Mérida (Spain) Birth Cohort who tested negative in the O'Sullivan screen. Neonatal normal values given as the mean (95% confidence interval) were: glucose, 75.3 mg/dL (68.29-82.29); cortisol, 7.4 microg/dL (6.85-7.97); GH, 16.7 ng/mL (14.87-18.60); insulin, 5.5 microUI/mL (4.12-6.88), IGF-155.2 ng/mL (50.82-59.53); QUICKI, 0.45 (0.43-0.48); HOMA-R, 1.36 (0.84-1.88); HOMA-S, 4.07 (2.66-5.49), the glucose/insulin ratio, 33.6 (24.58-42.67); the insulin/cortisol ratio, 0.8 (0.61-1.05). Hormone ranges (except for cortisol, whose values were lower) were equivalent to those of other studies. Cortisolaemia values cannot be associated with the type of delivery, as only three births (2.6%) were by caesarean section, while 20 (17.4%) were instrumental deliveries. Neonates from the lowest quartile of the insulin/cortisol ratio presented higher (p < 0.001) HOMA-S and QUICKI and lower (p < 0.01) HOMA-R values. The results of our study indicate normal ranges for insulin resistance and sensitivity at birth. The insulin/cortisol ratio at birth appears to be a good early indicator of insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Protocolmentioning

confidence: 99%

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Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Gesteiro¹,

Bastida

Sánchez‐Muniz

2008

Eur J Pediatr

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“…A total of 70 women completed the survey just before the first ultrasound pregnancy test at 12-15 week pregnancy, and were requested about their interest in performing an extra survey after delivery on major dietary changes occurring during the second and third trimesters. At weeks 24-28 of pregnancy, coinciding with their O'Sullivan glucose tolerance test, 26 information about twin pregnancies and gestational diabetes was obtained. A total of 16 mothers were excluded.…”

Section: Subjects and Methods Subjectsmentioning

confidence: 99%

Maternal diets with low healthy eating index or mediterranean diet adherence scores are associated with high cord-blood insulin levels and insulin resistance markers at birth

et al. 2012

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“…Our group has defined reference values for insulin resistance/sensitivity markers in neonates [59]. These ranges were obtained considering strict criteria at birth, as only term, normoweight, appropriate for gestational age, and without foetal distress (Apgar test evaluation) neonates whose mothers had normal glucose tolerance (O'Sullivan test evaluation) were studied [61]. The insulin resistance/sensitivity was calculated by the following indexes: quantitative insulin sensitivity check index (QUICKI), using the formula: 1/[(log Insulin)(μUI/mL) + (log Glucose) (mg/dL)]; homeostatic model assessment-insulin resistance (HOMA-IR), calculated as: Glucose (mmol/L) × Insulin (μUI/mL)/22.5.…”

Section: Reference Values In Neonates: Insulin Resistance/sensitivitymentioning

confidence: 99%

Hypercortisolaemia and Hyperinsulinaemia Interaction and their Impact upon Insulin Resistance/Sensitivity Markers at Birth

Alejos¹,

Sánchez‐Muniz²,

Bastida³

2017

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

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Information on insulin resistance/sensitivity in term-normoweight neonates is scarce. The hypothalamus-pituitary-adrenal cortex axis and pancreas are implicated in several aspects of foetal maturation and programming. This study aims to analyse the effects of a combination of hyperinsulinaemia plus hypercortisolaemia in such neonates together with their mothers℉ gestational glucose tolerance on growth hormone (GH), insulin-like growth factor-1 (IGF)-1, glucose, and insulin resistance/sensitivity markers [homeostatic model assessment-insulin resistance (HOMA-IR)/quantitative insulin sensitivity check index (QUICKI)] at birth. Furthermore, the importance of pregnancy diet quality on these markers is discussed. In a selected group of 187 term-normoweight non-distressed neonates, about 9% had increased insulin and cortisol cord-blood concentrations. In spite of normality criteria applied, the combination of hypercortisolaemia and hyperinsulinaemia at birth was associated with higher body weight, body length, glucose, HOMA-IR, GH, IGF-1 and glucose/insulin ratio values than those of neonates presenting low/normal concentrations of insulin and cortisol. Hyperinsulinaemia preferentially to hypercortisolaemia affected the markers studied. Impaired glucose tolerance prevalence was higher in mothers whose neonates were hyperinsulinaemic at birth. The hyperinsulinaemic plus hypercortisolaemic status was more prevalent in neonates whose mothers had poor Mediterranean diet adherence. Results show the importance of analysing insulin and cortisol in cord-blood even in termnormoweight neonates.

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Gestational Diabetes

Cited by 12 publications

References 33 publications

Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Insulin resistance markers in term, normoweight neonates. The Mérida cohort

Maternal diets with low healthy eating index or mediterranean diet adherence scores are associated with high cord-blood insulin levels and insulin resistance markers at birth

Hypercortisolaemia and Hyperinsulinaemia Interaction and their Impact upon Insulin Resistance/Sensitivity Markers at Birth

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