Gestational Diabetes is Associated with an Increased Expression of miR-27a in Peripheral Blood Mononuclear Cells

Radojičić, Ognjen; Dobrijević, Zorana; Robajac, Dragana; Gligorijević, Nevenka; Markovic, Vesna Mandic; Miković, Željko; Nedić, Olgica

doi:10.1007/s40291-022-00591-5

Cited by 10 publications

(10 citation statements)

References 57 publications

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“…Patient characteristics were extracted from all included studies to investigate overall heterogeneity regarding included patients. Ten studies diagnosed GDM using IADPSG criteria [ 9 , 19 , 20 , 21 , 24 , 29 , 31 , 33 , 43 , 55 ], seven used ADA criteria [ 17 , 18 , 25 , 28 , 34 , 37 , 38 ], three used national guidelines [ 16 , 36 , 51 ], and one study used WHO criteria [ 22 ], while the remaining studies did not define GDM diagnosis according to any explicit diagnostic criteria ( Supplementary Materials; Data Extraction Sheet ). Patients were generally included with no specific reference to the BMI of patients and control subjects; however, four studies only investigated obese or overweight subjects [ 18 , 20 , 21 , 37 ], and one study only investigated subjects with a BMI < 25 kg/m 2 [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…The sample material varied between plasma (32%) [ 25 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 51 ], serum (53%) [ 9 , 16 , 17 , 18 , 20 , 21 , 22 , 23 , 37 , 38 , 43 , 46 , 47 , 48 , 55 ], whole blood [ 24 ], and EVs (14%) [ 19 , 36 , 41 , 52 ]. Circulating miRNAs were quantified using a variety of approaches, such as discovery studies using small RNA sequencing followed by single miRNA reverse transcription–quantitative PCR (RT-qPCR) validation of selected miRNAs, RT-qPCR arrays, or candidate panels of single RT-qPCR assay, where RT-qPCR was by far the most used methodology.…”

Section: Resultsmentioning

confidence: 99%

“… Forest plots of the fixed-effect meta-analysis of ( A ) miR-17 [ 30 , 33 , 37 ], ( B ) miR-103 [ 16 , 20 , 21 ], ( C ) miR-125a/b [ 18 , 37 , 52 ], ( D ) miR-210 [ 28 , 33 , 41 ], and ( E ) miR-222 [ 18 , 28 , 29 , 51 ]. …”

Section: Resultsmentioning

confidence: 99%

“…A total of 4 studies examined miR-222 [ 18 , 28 , 29 , 51 ] and included 126 control subjects and 162 GDM patients. The SMD of the meta-analysis was −0.12, corresponding to an overall fold change of 0.88 in GDM patients (CI: −0.36–0.12 p > 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…Green scale (right side) corresponds to the percentage of NOS scale points fulfilled, and blue scale (left side) corresponds to the percentage of NOS scale points not fulfilled. References for evaluated studies: Pfeiffer et al (2020) [ 16 ], Ke et al (2022) [ 17 ], Zhao et al (2011) [ 18 ], Ye et al (2022) [ 19 ], Sørensen et al (2022) [ 20 ], Sørensen et al (2021) [ 21 ], Juchnicka et al (2022) [ 22 ], Abdeltawab et al (2022) [ 23 ], Stirm et al (2018) [ 24 ], Peng et al (2018) [ 25 ], Zhang et al (2021) [ 26 ], Wei et al (2021) [ 27 ], Wander et al (2017) [ 28 ], Radojičić et al (2022) [ 29 ], Martinez-Ibarra et al (2019) [ 9 ], Cao et al (2017) [ 30 ], Yoffe et al (2019) [ 31 ], Nair et al (2018) [ 32 ], Hromadnikova et al (2022) [ 33 ], Tagoma et al (2018) [ 34 ], Niu et al (2022) [ 35 ], Nair et al (2021) [ 36 ], Lamadrid-Romero et al (2018) [ 37 ], Zhou et al (2019) [ 38 ], Yu et al (2021) [ 39 ], Wang et al (2021) [ 40 ], Gillet et al (2019) [ 41 ], Li et al (2021) [ 42 ], Hocaoglu et al (2019) [ 43 ], Wen et al (2021) [ 44 ], Shen et al (2021) [ 45 ], Bhushan et al (2022) [ 46 ], Xiao et al (2020) [ 47 ], Zhang et al (2020) [ 48 ].…”

Section: Figurementioning

confidence: 99%

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Circulating microRNA as Biomarkers for Gestational Diabetes Mellitus—A Systematic Review and Meta-Analysis

Dinesen

El-Faitarouni

Frisk

et al. 2023

IJMS

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Gestational diabetes mellitus (GDM) is a severe pregnancy complication for both the woman and the child. Women who suffer from GDM have a greater risk of developing Type 2 diabetes mellitus (T2DM) later in life. Identification of any potential biomarkers for the early prediction of gestational diabetes can help prevent the disease in women with a high risk. Studies show microRNA (miRNA) as a potential biomarker for the early discovery of GDM, but there is a lack of clarity as to which miRNAs are consistently altered in GDM. This study aimed to perform a systematic review and meta-analysis to investigate miRNAs associated with GDM by comparing GDM cases with normoglycemic controls. The systematic review was performed according to PRISMA guidelines with searches in PubMed, Web of Science, and ScienceDirect. The primary search resulted in a total of 849 articles, which were screened according to the prior established inclusion and exclusion criteria. Following the screening of articles, the review was based on the inclusion of 35 full-text articles, which were evaluated for risk of bias and estimates of quality, after which data were extracted and relative values for miRNAs were calculated. A meta-analysis was performed for the miRNA species investigated in three or more studies: MiR-29a, miR-330, miR-134, miR-132, miR-16, miR-223, miR-155, miR-122, miR-17, miR-103, miR-125, miR-210, and miR-222. While some miRNAs showed considerable between-study variability, miR-29a, miR-330, miR-134, miR-16, miR-223, and miR-17 showed significant overall upregulation in GDM, while circulating levels of miR-132 and miR-155 were decreased among GDM patients, suggesting further studies of these as biomarkers for early GDM discovery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Circulating microRNA as Biomarkers for Gestational Diabetes Mellitus—A Systematic Review and Meta-Analysis

Dinesen

El-Faitarouni

Frisk

et al. 2023

IJMS

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The involvement of circulating miR‐146a and miR‐27a in patients with atherosclerotic cardiovascular disease after SARS‐CoV‐2 infection

Zhou,

Wei,

et al. 2024

Clinical Cardiology

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BackgroundAtherosclerotic cardiovascular disease (ASCVD) is a group of clinical diseases based on pathology of atherosclerosis that is the leading cause of mortality worldwide. There is a bidirectional interaction between ASCVD and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Alterations in circulating miRNAs levels are involved in the development of ASCVD in patients infected with SARS‐CoV‐2, however, the correlation between ASCVD co‐infection with SARS‐CoV‐2 and alterations of cardiac‐specific miRNAs is not well understood.HypothesisThe circulating miR‐146a and miR‐27a are involved in bidirectional interactions between ASCVD and SARS‐CoV‐2 infections.MethodsCirculating miR‐146a and miR‐27a levels were measured in serum and PBMCs deriving from ASCVD patients and controls after SARS‐CoV‐2 infection by qRT‐PCR analysis. The levels of neutralizing antibodies‐resistant SARS‐CoV‐2 in human serum was determined by competitive magnetic particle chemiluminescence method. Interleukin (IL)‐6 levels were detected by automatic biochemical analyzer using electrochemiluminescence.ResultsSignificant downregulation of circulating miR‐146a and upregulation of miR‐27a in ASCVD patients after infection with SARS‐CoV‐2 compared with controls were observed, among which the alterations were more evident in ASCVD patients comorbid with hyperlipidemia and diabetes mellitus. Consistently, correlation analysis revealed that serum miR‐146a and miR‐27a levels were associated with the levels of lipids and glucose, inflammatory response, and immune function in ASCVD patients. Remarkably, SARS‐CoV‐2 S protein RBD stimulation of PBMCs derived from both ASCVD and controls significantly downregulated miR‐146a, upregulated miR‐27a expression levels, and promoted IL‐6 release in vitro.ConclusionsThe circulating miR‐146a and miR‐27a are involved in metabolism, inflammation, and immune levels in patients with ASCVD after SARS‐CoV‐2 infection, laying the foundation for the development of strategies to prevent the risk of SARS‐CoV‐2 infection in ASCVD patients.

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Hsa_circ_0006260 Mediates Trophoblast Function by Fibronectin Type III Domains Containing Protein 5 via Interacting with miR-770-5p

Liu,

Hu,

Huang

et al. 2024

Biochem Genet

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Gestational Diabetes is Associated with an Increased Expression of miR-27a in Peripheral Blood Mononuclear Cells

Cited by 10 publications

References 57 publications

Circulating microRNA as Biomarkers for Gestational Diabetes Mellitus—A Systematic Review and Meta-Analysis

Circulating microRNA as Biomarkers for Gestational Diabetes Mellitus—A Systematic Review and Meta-Analysis

The involvement of circulating miR‐146a and miR‐27a in patients with atherosclerotic cardiovascular disease after SARS‐CoV‐2 infection

Hsa_circ_0006260 Mediates Trophoblast Function by Fibronectin Type III Domains Containing Protein 5 via Interacting with miR-770-5p

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