Gestational diabetes in the United States: temporal trends 1989 through 2004

Getahun, Darios; Nath, Carl; Ananth, Cande V.; Chavez, Martin; Smulian, John C.

doi:10.1016/j.ajog.2007.11.017

Cited by 251 publications

(178 citation statements)

References 15 publications

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“…Nevertheless, and in keeping with our previous studies (Darios et al 2008), our proteomics data are suggestive of increased inflammation in omental adipose tissue GDM.…”

Section: Discussionsupporting

confidence: 66%

“…Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy (Kuhl 1998), affects up to 18% of all pregnancies (Pregnancy 2010). Like type 2 diabetes, the prevalence rate of GDM has also increased dramatically in the last decade (Darios et al 2008, Laws & Sullivan 2009. Importantly, it is considered an important driver for the type 2 diabetes epidemic in many populations.…”

Section: Introductionmentioning

confidence: 99%

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2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue

Oliva

Barker

Rice

et al. 2013

Journal of Endocrinology

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Gestational diabetes mellitus (GDM) is a significant risk factor for the type 2 diabetes epidemic in many populations. Maternal adipose tissue plays a central role in the pathophysiology of GDM. Thus, the aim of this study was to determine the effect of GDM on the proteome of adipose tissue. Omental adipose tissue was obtained at the time of term Caesarean section from women with normal glucose tolerance (NGT) or GDM. 2D-difference gel electrophoresis (DIGE), followed by mass spectrometry, was used to identify protein spots (nZ6 patients per group). Western blotting was used for confirmation of six of the spot differences (nZ6 patients per group). We found 14 proteins that were differentially expressed between NGT and GDM adipose tissue (R1.4-fold, P!0.05). GDM was associated with an up-regulation of four proteins: collagen alpha-2(VI) chain (CO6A2 (COL6A2)), fibrinogen beta chain (FIBB (FGB)), lumican (LUM) and S100A9. On the other hand, a total of ten proteins were found to be down-regulated in adipose tissue from GDM women. These were alpha-1-antitrypsin (AIAT (SERPINA1)), annexin A5 (ANXA5), fatty acid-binding protein, adipocyte (FABP4), glutathione S-transferase P (GSTP (GSTP1)), heat-shock protein beta-1 (HSP27 (HSPB1)), lactate dehydrogenase B chain (LDHB), perilipin-1 (PLIN1), peroxiredoxin-6 (PRX6 (PRDX6)), selenium-binding protein 1 (SBP1) and vinculin (VINC (VCL)). In conclusion, proteomic analysis of omental fat reveals differential expression of several proteins in GDM patients and NGT pregnant women. This study revealed differences in expression of proteins that are involved in inflammation, lipid and glucose metabolism and oxidative stress and added further evidence to support the role of visceral adiposity in the pathogenesis of GDM.

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“…Nevertheless, and in keeping with our previous studies (Darios et al 2008), our proteomics data are suggestive of increased inflammation in omental adipose tissue GDM.…”

Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue

Oliva

Barker

Rice

et al. 2013

Journal of Endocrinology

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“…Various studies have presented similar results, highlighting concerns about increasing levels of diabetes in young women, a group which was thought to be at lower risk. 9,11 In the 15-24 age group, during this period, there was a 6.4 fold increase in the proportion of records of diabetes in hospital births. Health, resolution in 1998, b increasing remuneration for normal delivery and establishing a maximum payment limit for cesareans per hospital, may have contributed to the drop in cesarean rates in the SUS.…”

Section: Discussionmentioning

confidence: 90%

Diabetes nos partos hospitalares em sistemas de saúde público e privado

et al. 2013

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OBJETIVE:To analyze trends of diagnoses of diabetes mellitus in hospital deliveries. METHODS:Transversal study analyzing data on hospital deliveries for pregnant women living in Ribeirao Preto, SP, from 1998 to 2007. The data on diabetes mellitus in pregnancy were obtained from the Faculdade de Medicina de Ribeirao Preto of the Universidade de São Paulo Hospital Data Processing Center. The data analyzed were: age group, type of delivery (vaginal or cesarean), length of hospitalization and type of care: public (SUS) or private (private and supplemented health care). RESULTS:There was a 3.9 fold increase in the proportion of deliveries with a record of diabetes in relation to the total number of births (p = 0.01). This increase was of 4.5 times in deliveries in the public health care system (p = 0.01) and 3 times in private care. An increase in the presence of diabetes was observed in all age groups, proportionally larger in lower age groups. The frequency of cesarean delivery in pregnancies which recorded diabetes fell from 64.5% in 1998/1999 to 39.8% in 2006/2007 in the public system; in the private system the frequency remained over 90%. CONCLUSIONS:The presence of diabetes mellitus in hospital deliveries increased throughout the two year periods, despite a fall in the overall number of deliveries and an increase in the number of women of childbearing age living in Ribeirao Preto. This trend means that not only diagnosis and treatment, but also pre-pregnancy interventions which may reverse it are called for.

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“…Additionally, it recommends that women with glucose intolerance, excluding overt diabetes, with onset in or first recognized in pregnancy be classified as having gestational diabetes mellitus (GDM). Research has shown that the prevalence of both PDM (type 1 and type 2 diabetes) and GDM has been increasing over time in the USA (3)(4)(5)(6) .…”

mentioning

confidence: 99%

Differences in breast-feeding initiation and continuation by maternal diabetes status

Oza-Frank

Chertok

Bartley

2014

Public Health Nutr.

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Objective: To examine (i) the prevalence of and associations between breastfeeding initiation and continuation by maternal diabetes status and (ii) the reasons for not initiating and/or continuing breast-feeding by maternal diabetes status. Design: Secondary data analyses of a population-based cross-sectional study were conducting using data from the US Centers for Disease Control and Prevention's Pregnancy Risk Assessment Monitoring System (PRAMS), 2009-2011. Multivariable logistic regression was used to investigate the associations between breast-feeding initiation and continuation by diabetes status. Setting: Thirty states and New York City, USA. Subjects: Mothers of recently live-born infants, selected by birth certificate sampling. Results: Among 72 755 women, 8·8 % had gestational diabetes mellitus (GDM) and 1·7 % had pregestational diabetes mellitus (PDM). Breast-feeding initiation was similar among GDM and no diabetes mellitus (NDM) women (80·8 % v. 82·2 %, respectively, P = 0·2), but continuation was lower among GDM (65·7 % v. 68·8 %, respectively, P = 0·01). PDM women had lower initiation and continuation compared with NDM (78·2 %, P = 0·03 and 60·4 %, P < 0·01, respectively). In adjusted analyses, current smoking status was a significant effect modifier for initiation, but not for continuation. Conclusions: Differences in breast-feeding initiation and continuation prevalence by maternal diabetes status may reflect differences in prenatal education, indicating the need for increased efforts among PDM women. Additionally, nonsmoking women with PDM or GDM would benefit from additional breast-feeding education.

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Gestational diabetes in the United States: temporal trends 1989 through 2004

Cited by 251 publications

References 15 publications

2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue

2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue

Diabetes nos partos hospitalares em sistemas de saúde público e privado

Differences in breast-feeding initiation and continuation by maternal diabetes status

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