Gestational Diabetes Impairs Human Fetal Postprandial Brain Activity

Linder, Katarzyna; Schleger, Franziska; Kiefer-Schmidt, Isabelle; Fritsche, Louise; Kümmel, Stefanie; Heni, Martin; Weiss, Martin; Häring, Hans‐Ulrich; Preißl, Hubert; Fritsche, Andreas

doi:10.1210/jc.2015-2692

Cited by 54 publications

(60 citation statements)

References 31 publications

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“…A total of 72 pregnant women were enrolled in this study. They took part in a trial examining fetal response latencies to auditory stimuli measured with fMEG before and during an OGTT . During the fMEG measurement, fetal and maternal MCG were recorded simultaneously.…”

Section: Methodsmentioning

confidence: 99%

“…During the fMEG measurement, fetal and maternal MCG were recorded simultaneously. The results of fetal brain activity of 40 women taking part in the present study measured with fMEG were reported in a previously published paper …”

Section: Methodsmentioning

confidence: 99%

“…Our group recently published that human fetuses of insulin‐resistant mothers and mothers with GDM show alterations of the developing central nervous system . When performing fetal magnetoencephalography (fMEG) during an oral glucose tolerance test (OGTT), latencies of evoked fetal brain responses increased in pregnancies complicated by GDM compared with pregnancies in mothers with normal glucose tolerance . These results might indicate that maternal metabolism prenatally programmes central insulin resistance of the fetus with potential consequences in later life as described above.…”

Section: Introductionmentioning

confidence: 99%

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Gestational diabetes alters the fetal heart rate variability during an oral glucose tolerance test: a fetal magnetocardiography study

Fehlert

Fritsche

et al. 2016

BJOG

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gestational diabetes alters the fetal heart rate variability during an oral glucose tolerance test: a fetal magnetocardiography study

Fehlert

Fritsche

et al. 2016

BJOG

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“…However, even modest differences in food intake or food choices in early life can have lifelong repercussions, and the metabolic status of the mother during gestation influences the brain dynamics of the fetus (18). Obesity is most prevalent in lower socio-economic groups, and this is likely to reflect genetics (assortative mating), epigenetics and environmental factors.…”

Section: Early Life Experiencesmentioning

confidence: 99%

The determinants of food choice

et al. 2016

Self Cite

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Health nudge interventions to steer people into healthier lifestyles are increasingly applied by governments worldwide, and it is natural to look to such approaches to improve health by altering what people choose to eat. However, to produce policy recommendations that are likely to be effective, we need to be able to make valid predictions about the consequences of proposed interventions, and for this, we need a better understanding of the determinants of food choice. These determinants include dietary components (e.g. highly palatable foods and alcohol), but also diverse cultural and social pressures, cognitive-affective factors (perceived stress, health attitude, anxiety and depression), and familial, genetic and epigenetic influences on personality characteristics. In addition, our choices are influenced by an array of physiological mechanisms, including signals to the brain from the gastrointestinal tract and adipose tissue, which affect not only our hunger and satiety but also our motivation to eat particular nutrients, and the reward we experience from eating. Thus, to develop the evidence base necessary for effective policies, we need to build bridges across different levels of knowledge and understanding. This requires experimental models that can fill in the gaps in our understanding that are needed to inform policy, translational models that connect mechanistic understanding from laboratory studies to the real life human condition, and formal models that encapsulate scientific knowledge from diverse disciplines, and which embed understanding in a way that enables policy-relevant predictions to be made. Here we review recent developments in these areas.

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“…One interesting study recorded fetal brain activity triggered by glucose ingestion in healthy or GD pregnant subjects, and associated diabetes to a slower brain response of the offspring (Linder et al 2015). Using a STZ rat model, Jing et al (2014) found a decreased expression of IGF-1 and increased expression of insulin receptors in brains of E14, E16 and E18 fetuses from diabetic mothers, effects that were accompanied by reduced number of dendritic spines and smaller levels of the pre-synaptic protein synaptophysin.…”

Section: Memory and Brain Insulin Signalingmentioning

confidence: 99%

Consequences of gestational diabetes to the brain and behavior of the offspring

Sousa

Torres

Figueiredo

et al. 2018

An. Acad. Bras. Ciênc.

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Gestational diabetes mellitus (GD) is a form of insulin resistance triggered during the second/third trimesters of pregnancy in previously normoglycemic women. It is currently estimated that 10% of all pregnancies in the United States show this condition. For many years, the transient nature of GD has led researchers and physicians to assume that long-term consequences were absent. However, GD diagnosis leads to a six-fold increase in the risk of developing type 2 diabetes (T2D) in women and incidence of obesity and T2D is also higher among their infants. Recent and concerning evidences point to detrimental effects of GD on the behavior and cognition of the offspring, which often persist until adolescence or adulthood. Considering that the perinatal period is critical for determination of adult behavior, it is expected that the intra-uterine exposure to hyperglycemia, hyperinsulinemia and pro-inflammatory mediators, hallmark features of GD, might affect brain development. Here, we review early clinical and experimental evidence linking GD to consequences on the behavior of the offspring, focusing on memory and mood disorders. We also discuss initial evidence suggesting that downregulation of insulin signaling cascades are seen in the brains of GD offspring and could contribute to the consequences on their behavior.

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Gestational Diabetes Impairs Human Fetal Postprandial Brain Activity

Abstract: Fetal postprandial brain responses were slower in the offspring of women with GDM. This might indicate that gestational diabetes directly affects fetal brain development and may lead to central nervous insulin resistance in the fetus.

Cited by 54 publications

References 31 publications

Gestational diabetes alters the fetal heart rate variability during an oral glucose tolerance test: a fetal magnetocardiography study

Gestational diabetes alters the fetal heart rate variability during an oral glucose tolerance test: a fetal magnetocardiography study

The determinants of food choice

Consequences of gestational diabetes to the brain and behavior of the offspring

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