Gestational caloric restriction improves redox homeostasis parameters in the brain of Wistar rats: a screening from birth to adulthood

Stone, Vinícius; Crestani, Mariana Scortegagna; Saccomori, André Brum; Magro, Bárbara Mariño Dal; Maurmann, Rafael Moura; August, Pauline Maciel; Santos, Bernardo Gindri dos; Klein, Caroline; Hackenhaar, Fernanda Schäfer; Benfato, Mara da Silveira

doi:10.1016/j.jnutbio.2019.02.002

Cited by 8 publications

(8 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the hippocampus, even with increased mitochondrial function, superoxide was reduced. In a previous study, we had already observed similar modulation in concern to redox homeostasis, including DCFH oxidation, antioxidants modulation, and biomolecule damage; evidenced by impaired redox homeostasis at birth followed by adaptation throughout life, culminating in improved redox homeostasis in adulthood (Stone et al, 2019).…”

Section: Discussionmentioning

confidence: 55%

“…It is important to note that in Mayeur's study, no micronutrients malnutrition prevention was performed and the animals were submitted to a more severe restriction protocol (30%). If on one hand, our group showed positive redox modulation on pups born from 20% caloric restricted dams (concerning micronutrients malnutrition prevention) (Stone et al, 2019), on the other hand, 40% food restriction (without preventing malnutrition) caused several disruption in pups' and dams' redox homeostasis (Stone et al, 2016).…”

Section: Discussionmentioning

confidence: 87%

“…This concept evolved from Barker's studies on the thrifty phenotype, or Barker's hypothesis (Barker et al, 1989). Our group already showed how several different interventions may influence the offspring health when applied during pregnancy, such as Caloric Restriction (CR) (Stone et al, 2019), food restriction (FR) (Stone et al, 2016), high‐salt diet (Stocher et al, 2018), polyphenol supplementation (August et al, 2018), and swimming exercise (August et al, 2018; Klein et al, 2018, 2019; Marcelino et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Lamentably, this condition is similar to the general human population and also to pregnant women around the world, taking into account that obesity ratio between pregnant women is growing (Fisher et al, 2013) along with obese children population (de Onis et al, 2010). It is always important to state that CR protocol should not promote malnutrition, thus, considering equal or similar micronutrients consumption when comparing to control animals (Stone et al, 2019; McCay et al, 1935; Cerqueira and Kowaltowski, 2010).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adaptive effects of gestational caloric restriction in the mitochondria of Wistar rats' brain: A DOHaD approach

Stone

August

Crestani

et al. 2019

Intl J of Devlp Neuroscience

Self Cite

View full text Add to dashboard Cite

Developmental origins of health and disease (DOHaD) is a ield of biological science dedicated to investigating how diferent interventions during development afect an individual's life. Diet is an essential way to interact with the environment, and during pregnancy afects not only the mother but also can impact the next generations. One of these interventions is caloric restriction (CR), which has shown positive redox modulation in rats' ofspring when malnutrition is responsibly controlled. Considering that mitochondrial metabolism is determinant for redox status, we investigated parameters related to mitochondrial functionality and reactive species levels in ofspring's brain from rats delivered to pregnant caloric restricted dams. Therefore, pregnant rats were divided between control (ad libitum food) and CR (20% food restriction plus micronutrients supplementation) groups, and ofspring's brain was analyzed on post-natal days (PND) 0, 7, 21, and 60. Mitochondrial function, as well as superoxide content, were decreased in most brain areas on PND0 and went through adaptation, showing increased mass and membrane potential in adulthood. Concerning mitochondrial electron transport system (METS), the most afected area was the cerebellum, which was impaired at birth and activated at adulthood. In conclusion, our results show that gestational CR promotes adaptation from impaired mitochondrial parameters at birth, improving mitochondrial function when compared to control, without increasing superoxide generation, at adult age. More studies are necessary in order to support the use of CR as a clinical approach.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adaptive effects of gestational caloric restriction in the mitochondria of Wistar rats' brain: A DOHaD approach

Stone

August

Crestani

et al. 2019

Intl J of Devlp Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…The female Wistar rats were mated in a proportion of 1 male to 2 females per cage, and the pregnancy diagnosis was confirmed by the presence of sperm in the vaginal smear and it was considered as the gestational day zero [ 32 ]. Pregnant rats were randomly divided into two experimental groups treated by oral gavage: control (equivalent volume of distilled water) and naringin groups (100 mg/kg/day).…”

Section: Methodsmentioning

confidence: 99%

Naringin Supplementation during Pregnancy Induces Sex and Region-Specific Alterations in the Offspring’s Brain Redox Status

Santos

Klein

Crestani

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy.

show abstract

Caloric restriction and the developing brain

Matté

2021

Factors Affecting Neurodevelopment

View full text Add to dashboard Cite

Gestational caloric restriction improves redox homeostasis parameters in the brain of Wistar rats: a screening from birth to adulthood

Cited by 8 publications

References 50 publications

Adaptive effects of gestational caloric restriction in the mitochondria of Wistar rats' brain: A DOHaD approach

Adaptive effects of gestational caloric restriction in the mitochondria of Wistar rats' brain: A DOHaD approach

Naringin Supplementation during Pregnancy Induces Sex and Region-Specific Alterations in the Offspring’s Brain Redox Status

Caloric restriction and the developing brain

Contact Info

Product

Resources

About