Gestational age-specific reference intervals for blood copper, zinc, calcium, magnesium, iron, lead, and cadmium during normal pregnancy

Zhang, Zhan; Yuan, Enwu; Liu, Junjie; Lou, Xiaofeng; Jia, Liting; Li, Xiaofu; Zhang, Linlin

doi:10.1016/j.clinbiochem.2013.03.004

Cited by 33 publications

(36 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the serum concentrations of Co and Cu were higher in pregnant women than in the general population, whereas Zn and Se levels were lower. Those results are similar to those of previous studies in Turkish, Chinese, and Chilean populations [8,23,33], except for Co because no previous study compared Co concentrations in pregnant women with those in the general population.…”

Section: Discussionsupporting

confidence: 91%

“…Although previous studies have reported reference ranges for trace element concentrations in healthy pregnant women using blood samples [8,23,28,33], only a few studies have reported those concentrations in comparison with those in a general population of healthy non-pregnant women or healthy men [8,23,33]. Comparisons of trace element concentrations in healthy pregnant women in different previous studies are summarized in Table 4.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women

et al. 2016

View full text Add to dashboard Cite

This prospective study sought to investigate serum levels of trace elements (cobalt, copper, zinc, and selenium) and to assess their effects on pregnancy and neonatal outcomes. Serum levels of trace elements in 245 Korean pregnant women (median gestational age at delivery was 39 + 4 weeks and interquartile range was 38 + 4–40 + 1 weeks) were compared with those of 527 general adults and those of previous studies in other ethnic groups. Pregnancy and neonatal outcomes including gestational diabetes, preeclampsia, neonatal birth weight, and congenital abnormalities were assessed. The median serum trace element concentrations of all pregnant women were: cobalt: 0.39 μg/L (interquartile range, IQR 0.29–0.53), copper: 165.0 μg/dL (IQR 144.0–187.0), zinc: 57.0 μg/dL (IQR 50.0–64.0), and selenium: 94.0 μg/L (IQR 87.0–101.0). Serum cobalt and copper concentrations were higher in pregnant women than in the general population, whereas zinc and selenium levels were lower (p < 0.01). Concentrations of all four trace elements varied significantly during the three trimesters (p < 0.05), and seasonal variation was found in copper, zinc, and selenium, but was not observed for cobalt. The prevalence of preeclampsia was significantly lower with high copper (p = 0.03). Trace element levels varied by pregnancy trimester and season, and alteration in copper status during pregnancy might influence pregnancy outcomes such as preeclampsia.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women

et al. 2016

View full text Add to dashboard Cite

show abstract

“…All the subjects were assigned into four groups according to weeks of gestation: 13-20 (Group A), 21-27 (Group B), 28-35 (Group C), and 36-42 (Group D) weeks of gestation [15]. A total of 677 healthy nonpregnant women aged 21-35 years from the health clinic served as controls.…”

Section: Study Population and Sample Collectionmentioning

confidence: 99%

Evaluation of lead and essential elements in whole blood during pregnancy: a cross-sectional study

et al. 2015

View full text Add to dashboard Cite

show abstract

“…These metabolic changes are demonstrable even for micronutrients. A recent cross-sectional study performed in 2,380 healthy pregnant women demonstrated significant changes in serum concentrations of trace elements (Cu, Zn, Ca, Mg, Fe, Pb and Cd) compared with nonpregnant controls and a positive correlation with weeks of gestation for all trace elements with the exception of Zn (p < 0.05) [13]. Differently than the other nutrients, blood Mg and Fe concentrations were inversely correlated with weeks of gestation (p < 0.05).…”

Section: Nutritional Phenotype Of Pregnancymentioning

confidence: 99%

“…Differently than the other nutrients, blood Mg and Fe concentrations were inversely correlated with weeks of gestation (p < 0.05). Changes in micronutrient concentrations may be explained by modified gut absorption during pregnancy, altered excretion and tissue metabolism as well as modified placental transport/fetal utilization [13,14]. …”

Section: Nutritional Phenotype Of Pregnancymentioning

confidence: 99%

Multiple Micronutrient Needs in Pregnancy in Industrialized Countries

2014

View full text Add to dashboard Cite

Background: As nutritional deficiencies are known to lead to adverse pregnancy outcomes, a woman's nutritional status should be assessed preconceptionally with the goal of optimizing maternal, fetal and infant health. Worldwide micronutrient intakes do not fit pregnancy requirements, so that their supplementation is recommended from the beginning of pregnancy in most of the low- and middle-income countries. Conversely, data on multiple supplementation in developed countries appear few and controversial. Key Message: Although a balanced diet is generally accessible in industrialized countries, a switch to a high-fat and low-quality diet has led to an inadequate vitamin and mineral intake during pregnancy, so that recent data show the micronutrient intake and supplementation to be lower than recommended even in high-income countries, particularly for iron, folic acid, calcium and vitamin D. Conclusions: Currently, even if there is insufficient evidence to support routine supplementation at the population level, except for periconceptional folate supplementation, these results need to be evaluated at an individual level in order to avoid nutritional deficiencies and to encourage women to establish healthful dietary practices prior to conception. The new goal in industrialized countries needs to be an individualized approach that takes account of the phenotypic, genotypic and metabolic differences among individuals of the same population.

show abstract

Gestational age-specific reference intervals for blood copper, zinc, calcium, magnesium, iron, lead, and cadmium during normal pregnancy

Cited by 33 publications

References 30 publications

A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women

A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women

Evaluation of lead and essential elements in whole blood during pregnancy: a cross-sectional study

Multiple Micronutrient Needs in Pregnancy in Industrialized Countries

Contact Info

Product

Resources

About