Gestational age and childhood leukemia: A meta-analysis of epidemiologic studies

Wang, Yang-Feng; Wu, Liqun; Liu, Yi-Ni; Bi, Yang; Wang, Hong

doi:10.1080/10245332.2017.1396056

Cited by 11 publications

(15 citation statements)

References 40 publications

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“…We also found the risk of AML to be increased, again confirming results previously published. 26,31 Yet, and unlike previous studies, we found a strong association between preterm birth and later diagnosis of a germ cell tumor or retinoblastoma. For hepatic tumors, we were hampered by the low numbers with only three cases in our preterm population, but the OR was suggestive of an elevated risk.…”

Section: Discussioncontrasting

confidence: 99%

“…20,21 The risk of developing childhood cancer after having been born preterm has been studied previously. [22][23][24][25][26][27][28] Certain subtypes of childhood cancer, that is, hepatoblastoma [27][28][29][30] and acute myeloid leukemia (AML), 26,31 have been found to be associated with preterm birth. The possible association between other childhood cancers and preterm birth, however, remains inconclusive.…”

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confidence: 99%

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Preterm birth, neonatal therapies and the risk of childhood cancer

Seppala

Vettenranta

Leinonen

et al. 2020

Intl Journal of Cancer

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Our aim was to study the impact of preterm birth and neonatal therapies on the risk of childhood cancer using a nationwide, registry‐based, case‐control design. Combining population‐based data from Finnish Medical Birth Registry (MBR) and Finnish Cancer Registry, we identified a total of 2029 patients diagnosed with cancer under the age of 20 years and 10 103 age‐ and sex‐matched controls over the years 1996 to 2014. Information on the prenatal and perinatal conditions was obtained from the MBR. Gestational age was categorized into early (<32) and late preterm (32‐36) and term (≥37 weeks). Cancer risk among the preterm compared to term neonates was evaluated using conditional logistic regression. We identified 141 cancers among the preterm (20.8% of 678) vs 1888 cancers in the term children (16.5% of 11 454). The risk of any cancer was increased for the preterm (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.06‐1.57), especially for the early preterm (OR 1.84, 95% CI 1.16‐2.92). The risk of acute myeloid leukemia (AML; OR 2.33, 95% CI 1.25‐4.37), retinoblastoma (OR 3.21, 95% CI 1.22‐8.41) and germ cell tumors (OR 5.89, 95% CI 2.29‐15.18) was increased among the preterm compared to term. Germ cell tumors were diagnosed at a significantly younger age among the preterm. Neonatal therapies, for example, mechanical ventilation, were associated with an increased risk of childhood cancer independent of gestational age. Preterm, especially early preterm birth, is associated with an increased risk of childhood cancer, especially germ cell tumors and AML. Respiratory distress requiring neonatal intervention also appears to be associated with an increased risk.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

Preterm birth, neonatal therapies and the risk of childhood cancer

Seppala

Vettenranta

Leinonen

et al. 2020

Intl Journal of Cancer

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“…In the functional analyses, we observed significant enrichment for several GO terms related to embryonic development, regulation of process and immune system development. The pathway analyses identified a subset of these genes linked to diseases also associated with low gestational age, for example asthma [83], inflammatory bowel disease [84], type I/II diabetes [85] and cancer (leukaemia) [86]. Importantly, genes annotated to CpGs found stable across childhood also showed enrichment for infection-and immune-related conditions.…”

Section: Discussionmentioning

confidence: 99%

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

et al. 2020

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Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4–18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27–42 weeks), at Bonferroni significance, P < 1.06 × 10− 7, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.

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“…94 This can be explained by the fact that preterm babies have immature lungs and other vital organs, which exposed them to respiratory problems including infections, facing difficulty to adapt the extra-uterine life. Premature newborns are at risk for death during the neonatal period 21 due to higher rates of associated neonatal morbidities such as neonatal sepsis, 95 neonatal near miss and foetal malformations, 96 leukaemia, 97 retinopathy of prematurity, 12,21 respiratory distress, feed intolerance and jaundice 98 and neonatal sepsis. [98][99][100] A recent study conducted in Ethiopia also showed the highest rate of preterm mortality was attributed to respiratory problems distress syndrome (45%), infections (30%) and asphyxia (14%).…”

Section: Discussionmentioning

confidence: 99%

Effect of Preterm Birth on the Risk of Adverse Perinatal and Neonatal Outcomes in Ethiopia: A Systematic Review and Meta-Analysis

Admas

Yeshitila

Meselu

et al. 2021

INQUIRY

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Despite remarkable progress in the reduction of under-five mortality, the rate of perinatal and neonatal mortality is still high especially in developing countries. The adverse outcome associated with preterm birth is one of the major public health challenges in Africa. However, there are limited and inconsistent studies conducted on the effect of preterm birth on adverse perinatal and neonatal outcomes in Ethiopia. Therefore, this systematic review and meta-analysis aimed to investigate the association between preterm birth and its adverse perinatal and neonatal outcomes in Ethiopia. We systematically searched several electronic databases like PubMed, Web of Science, SCOPUS, CINAHL, Google Scholar, African Journals Online databases and Science Direct. All identified observational studies were included. The I 1 statistics were used to assess the heterogeneity among the studies. A random-effects model was computed to estimate the pooled effect of preterm birth on adverse perinatal and neonatal outcomes. Thirty-three studies with a total of 20 109 live births were included in the final meta-analysis. Our meta-analysis showed that preterm birth increased the odds of perinatal mortality by 10-folds [POR = 9.56 (95% CI: 5.47, 19.69)] and there was a 5.44-folds risk of stillbirth [Odds Ratio = 5.44 (95% CI: 3.57, 8.28)] among women who gave birth before 37 weeks of gestation. In addition, preterm birth was significantly associated with neonatal hypothermia [OR=3.54 (95% CI: 2.41, 5.21)], neonatal mortality [OR= 3.16 (95% CI: 1.57, 6.34). The sub-group analysis of this meta-analysis showed that there was an increased risk of neonatal sepsis [OR=2.33 (95% CI: 1.15, 4.71)] among preterm babies. Preterm births significantly increased the risk of adverse perinatal and neonatal outcomes in Ethiopia. Therefore, scale-up strategies and improving the quality of maternal and child health care providers should be an area of intervention to reduce adverse outcomes associated with preterm birth. The Federal Ministry of Health and concerned bodies should work towards the prevention of preterm birth and its adverse outcomes.

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Gestational age and childhood leukemia: A meta-analysis of epidemiologic studies

Cited by 11 publications

References 40 publications

Preterm birth, neonatal therapies and the risk of childhood cancer

Preterm birth, neonatal therapies and the risk of childhood cancer

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Effect of Preterm Birth on the Risk of Adverse Perinatal and Neonatal Outcomes in Ethiopia: A Systematic Review and Meta-Analysis

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