Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada)

Lucas, Michel; Dewailly, Éric; Muckle, Gina; Ayotte, Pierre; Bruneau, Suzanne; Gingras, Suzanne; Rhainds, Marc; Holub, Bruce J.

doi:10.1007/s11745-004-1274-7

Cited by 69 publications

(54 citation statements)

References 89 publications

(99 reference statements)

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“…Data points for the lowest quintile of mercury exposure in the upper quartile of seafood intake (n 10) and for highest quintile of mercury exposure in the lowest quartile of seafood intake (n 39) are not shown due to low statistical power Our findings of estimated levels of dietary Hg exposure are in agreement with what was found in a study of Swedish women of childbearing age, as well as similar to dietary exposure levels reported worldwide in women of childbearing age (44,45) . Studies of maternal Hg exposure and infant birth weight have until recently not reported significant associations (25,46,47) . Although studies have found associations between exposure to other environmental contaminants accumulating in fish and seafood and fetal growth (48,49) , it is only recently that reports of a direct adverse association to low-level Hg exposure have been published.…”

Section: Discussionmentioning

confidence: 99%

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Vejrup

Brantsæter

Knutsen

et al. 2013

Public Health Nutr.

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Objective: To examine the association between calculated maternal dietary exposure to Hg in pregnancy and infant birth weight in the Norwegian Mother and Child Cohort Study (MoBa). Design: Exposure was calculated with use of a constructed database of Hg in food items and reported dietary intake during pregnancy. Multivariable regression models were used to explore the association between maternal Hg exposure and infant birth weight, and to model associations with small-for-gestational-age offspring. Setting: The study is based on data from MoBa. Subjects: The study sample consisted of 62 941 women who answered a validated FFQ which covered the habitual diet during the first five months of pregnancy. Results: Median exposure to Hg was 0?15 mg/kg body weight per week and the contribution from seafood intake was 88 % of total Hg exposure. Women in the highest quintile compared with the lowest quintile of Hg exposure delivered offspring with 34 g lower birth weight (95 % CI 246 g, 222 g) and had an increased risk of giving birth to small-for-gestational-age offspring, adjusted OR 5 1?19 (95 % CI 1?08, 1?30). Although seafood intake was positively associated with increased birth weight, stratified analyses showed negative associations between Hg exposure and birth weight within strata of seafood intake. Conclusions: Although seafood intake in pregnancy is positively associated with birth weight, Hg exposure is negatively associated with birth weight. Seafood consumption during pregnancy should not be avoided, but clarification is needed to identify at what level of Hg exposure this risk might exceed the benefits of seafood.

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Section: Discussionmentioning

confidence: 99%

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Vejrup

Brantsæter

Knutsen

et al. 2013

Public Health Nutr.

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“…The possible reasons why the maximum cord-blood T-Hg level was about 70 times higher than the minimum level are that daily fi sh intake and the kinds of fi sh consumed differed markedly among study populations and that the method and quality control of mercury analyses differed among these laboratories. For instance, since arctic or subarctic inhabitants used to eat seal or whale (Dennis and Fehr 1975;Bjerregaard and Hansen 2000;Lucas et al 2004;Grandjean et al 2005), the cord-blood T-Hg concentrations in these areas seemed to be high. Also, Dallaire et al (2003) analyzed 248 cordblood samples of Inuit infants born in Nunavik (Québec, Canada), which were collected from 1994 to 2001, and observed a signifi cant reduction of T-Hg concentrations in cord blood (8.3% per year), as well as polychlorinated biphenyls (PCBs) and lead, whereas the average mercury concentrations in Faroese pregnant women decreased because of a dietary advisory issued by the health authorities in 1998 .…”

Section: Analytical Methods Of Mercury In Cord Blood and Tissuementioning

confidence: 99%

“…Cord blood: Lead Buchet et al 1978;Lauwerys et al 1978;Tsuchiya et al 1984;Truska et al 1989;Soong et al 1991;Grandjean et al 1992;Ong et al 1993;Klopov 1998;Rhainds et al 1999;Dallaire et al 2003;Lucas et al 2004;Vigeh et al 2006;Walker et al 2006Cadmium Buchet et al 1978Lauwerys et al 1978;Tsuchiya et al 1984;Truska et al 1989;Soong et al 1991;Ong et al 1993;Klopov 1998;Vigeh et al 2006;Walker et al 2006Manganese Tsuchiya et al 1984Vigeh et al 2006Arsenic Soong et al 1991 Antimony and cobalt Vigeh et al 2006 Polychlorinated biphenyls (PCBs) Rhainds et al 1999;Grandjean et al 2001;Dallaire et al 2003;Lucas et al 2004 Pesticides Rhainds et al 1999 Cord tissue: Lead Noda et al 1983;Tsuchiya et al 1984;Sugiyama et al 1996;Shaheen et al 2004Cadmium Noda et al 1983Tsuchiya et al 1984;Sugiyama et al 1996Manganese Noda et al 1983Tsuchiya et al 1984;Shaheen et al 2004…”

Section: Toxicants Authorsmentioning

confidence: 99%

Assessment of Intrauterine Methylmercury Exposure Affecting Child Development: Messages from the Newborn

Murata

Dakeishi

Shimada

et al. 2007

Tohoku J. Exp. Med.

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“…In a Canadian study, the associations between n-3 LCPUFA and environmental contaminants (such as mercury, lead and PCBs) and gestational age and birth weight were investigated (Lucas et al, 2004). n-3 LCPUFA and contaminant concentrations were measured in cord plasma in a seafood eating population (Nunavik, n = 454) and in a comparison group from southern Québec (n = 29).…”

Section: Developmental Toxicity Other Than Neurotoxicity and Immunotomentioning

confidence: 99%

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

2012

EFS2

450

160

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EFSA was asked by the European Commission to consider new developments regarding inorganic mercury and methylmercury toxicity and evaluate whether the Joint FAO/WHO Expert Committee on Food Additives (JECFA) provisional tolerable weekly intakes for methylmercury of 1.6 µg/kg body weight (b.w.) and of 4 µg/kg b.w. for inorganic mercury were still appropriate. In line with JECFA, the CONTAM Panel established a tolerable weekly intake (TWI) for inorganic mercury of 4 µg/kg b.w., expressed as mercury. For methylmercury, new developments in epidemiological studies from the Seychelles Child Developmental Study Nutrition Cohort have indicated that n-3 long-chain polyunsaturated fatty acids in fish may counteract negative effects from methylmercury exposure. Together with the information that beneficial nutrients in fish may have confounded previous adverse outcomes in child cohort studies from the Faroe Islands, the Panel established a TWI for methylmercury of 1.3 µg/kg b.w., expressed as mercury. The mean dietary exposure across age groups does not exceed the TWI for methylmercury, with the exception of toddlers and other children in some surveys. The 95 th percentile dietary exposure is close to or above the TWI for all age groups. High fish consumers, which might include pregnant women, may exceed the TWI by up to approximately six-fold. Unborn children constitute the most vulnerable group. Biomonitoring data from blood and hair indicate that methylmercury exposure is generally below the TWI in Europe, but higher levels are also observed. Exposure to methylmercury above the TWI is of concern. If measures to reduce methylmercury exposure are considered, the potential beneficial effects of fish consumption should also be taken into account. Dietary inorganic mercury exposure in Europe does not exceed the TWI, but inhalation exposure of elemental mercury from dental amalgam is likely to increase the internal inorganic mercury exposure; thus the TWI might be exceeded. This opinion focuses only on the risks related to dietary inorganic mercury and methylmercury exposure and does not assess the nutritional benefits linked to certain foods (e.g. fish and other seafood).A call for annual collection of chemical contaminant occurrence data in food and feed, including mercury, was issued by EFSA in December 2010. In response, EFSA received 59 820 results on mercury in food from 20 European countries, mainly covering the period from 2004 to 2011. A total number of 59 650 results were described with sufficient detail to be used in the statistical analysis of the respective food groups; 98.2 % of the samples were for total mercury, 1.8 % for methylmercury and three samples for inorganic mercury.All the 20 food groups available at the first level of FoodEx were covered in the current data collection. The food groups 'Fish and other seafood' and 'Meat and meat products' dominated the food product coverage with 36.8 % and 17.6 % respectively. These were followed by 'Grain and grain-based products' at 7.8 % and 'Vegetables an...

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Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada)

Cited by 69 publications

References 89 publications

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study

Assessment of Intrauterine Methylmercury Exposure Affecting Child Development: Messages from the Newborn

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

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