Geroscience From Cell-body Dynamics and Proteostasis Cooperation Supported by αB-crystallin and Human will ~ A Proposal of “Body-Mind Integrative Science”

Atomi, Yoriko; Shimizu, Miho; Ohto-Fujita, Eri; Atomi, Aya; Hayasaki, Saaya; Higashi, Yoshikazu; Atomi, Tomoaki

doi:10.1007/978-3-319-74715-6_13

Cited by 3 publications

(2 citation statements)

References 103 publications

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“…5) through tubulin/ microtubules-FA axis and intermediate filament of vimentinnuclear lamin axis, because αB-crystallin is a chaperone for free form of three cytoskeletal proteins of actin, tubulin and intermediate filament. [29][30][31] Nuclear skeletal lamin is a member of intermediate filaments, and overexpression of αB-crystallin protects the heart in dilated cardiomyopathy, and αB-crystallin protects lamin by heat stress on myoblasts, 32) there is a possibility that αB-crystallin contributed to the stability of lamin from stretch stress.…”

Section: Discussionmentioning

confidence: 99%

Molecular chaperone αB-crystallin regulates the dynamic stability of focal adhesion under mechanical stress conditions

Hayasaki

Sasai

Imayasu

et al. 2020

Jpn. J. Appl. Phys.

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Resilience to stretch stress is an important characteristic that helps maintain cell adhesion and consequently, human health. This study aimed to elucidate the underlying mechanism of adaptation to stretch stress regulated by the molecular chaperone αB-crystallin. Three rat myoblast L6 cell lines, wild type (L6-WT), αB-crystallin knock down (L6-KD), and αB-crystallin overexpressing (L6-OE) cells were used. Muscle cells are less motile because they are specialized for contraction. Forced stretch stress was given to the three cell lines on a soft adhesive sheet, and we found that L6-OE cells showed the highest resilience to stretch stress and the least motility compared to other cell lines. Conversely, L6-KD cells showed the least resilience to stretch stress. Vinculin staining showed that total focal adhesion (FA) size and area of L6-OE cells were significantly larger than those of other cell types. Thus αB-crystallin in myoblast cells contributes the resilience of FA stability during stretch stress.

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Section: Discussionmentioning

confidence: 99%

Molecular chaperone αB-crystallin regulates the dynamic stability of focal adhesion under mechanical stress conditions

Hayasaki

Sasai

Imayasu

et al. 2020

Jpn. J. Appl. Phys.

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“…In 2016, Baghini [7] simultaneously examined the cement and Styrene-butadiene rubber and studied the effect of this additive material on road construction. Yahya Atomi et al [8], have effectively improved soil properties by examining the improvement of soil properties of sterol butadiene rubber polymer. In 2020, Zimbardo et al [9] used a special polymer in collapsible sand and observed a decrease in the compressibility of sand soil.…”

Section: Introductionmentioning

confidence: 99%

Collapsibility Prediction of Stabilized Soil with Styrene-Butadiene Rubber Polymer Using ANFIS

2022

Teh. vjesn.

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Collapsible soils are among the problematic soils in nature that, due to moisture content increasing and under the same stress, show a high rate of decrease in volume. This volume reduction leads to loss of soil structure and ultimately to significant subsidence. Such soils in many parts of the world, including the Kerman province of Iran, necessitate researches regarding the collapsible soils' behavior and characteristics. This study aims to investigate the effect of butadiene rubber on the stabilization of collapsible soils. The tested fine-grained soils that have been sampled from two different sites were stabilized through injecting different percentages of butadiene (the number of experiments was 84). The ASTM D5333 Double-Consolidation Method was applied to examine the stabilized soils on intact soil samples. The results show that the penetrations of butadiene rubber and the formation of butadiene rubber columns have led to a reduction in soil collapse. Considering the development of intelligent systems using the prediction behavior of stabilized collapsible soils, the adaptive neural-fuzzy inference system (ANFIS) model was used to predict the degree of collapsibility of soil samples stabilized by injection of Styrene Butadiene Rubber.

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Practical Life Science to Understand and Utilize Your Own Body in which Cells Dynamically Respond to Dynamics

Atomi

2022

Emotional Engineering, Vol. 9

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Geroscience From Cell-body Dynamics and Proteostasis Cooperation Supported by αB-crystallin and Human will ~ A Proposal of “Body-Mind Integrative Science”

Cited by 3 publications

References 103 publications

Molecular chaperone αB-crystallin regulates the dynamic stability of focal adhesion under mechanical stress conditions

Molecular chaperone αB-crystallin regulates the dynamic stability of focal adhesion under mechanical stress conditions

Collapsibility Prediction of Stabilized Soil with Styrene-Butadiene Rubber Polymer Using ANFIS

Practical Life Science to Understand and Utilize Your Own Body in which Cells Dynamically Respond to Dynamics

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