Gerodontology: effects of ageing on the oral mucosa

Rivera, César; Arenas-Márquez, María Jesús

doi:10.4067/s0719-01072017000100009

Cited by 11 publications

(10 citation statements)

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“…Other CT areas showed some inflammatory cell infiltration. These findings matched those of Revira, et al [ 12] , who found that aging resulted in reduction in epithelial ridges, epithelial atrophy, reduction of cellular density and mitotic activity. They also reported increase in fibrous elements of CT in relation to its cellular components.…”

Section: Discussionsupporting

confidence: 91%

“…In oral tissues, this structural agerelated changes predispose to various oral diseases if not properly managed. Meanwhile, the aging process reduces tissue ability for regeneration due to decreased cellular density and mitotic activity, and this must be carefully considered while choosing a line of treatment like an implant or denture or so [ 12] . Agwaral, et al [ 13] , stated that age-related oral diseases can cause xerostomia, generalized oral pain, difficulty in speaking, mastication, and swallowing, thus compromising the patient's quality of life.…”

Section: Discussionmentioning

confidence: 99%

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Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

Awwad

2020

Egyptian Dental Journal

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Introduction: Aging greatly diminishes the ability of oral tissues to withstand various types of functional insults, and reduces cell regeneration. Hence, anti-oxidation is mandatory to preserve oral tissues especially while aging. Melatonin is an anti-oxidant with established potential in hindering age-related changes. Aim: to evaluate the extent of anti-oxidant and anti-inflammatory potentials of melatonin on aged hard palatal tissues of rats. Materials and Methods: twenty-one Albino rats 200-250 gms each, were used in this study. They were equally divided into 3 groups; Control Young Gp: 6 months of age, Control Senile Gp:18 months of age, and Melatonin Gp: 18 months of age. After 8 weeks, rats were sacrificed by high dose of anesthesia. The hard-palatal mucosae of all rats were separated and processed for histologic examination by H&E, Masson Trichrome stain, and immuno-histochemical staining by Anti-PCNA, then examined by light microscopy. Results: the control senile Gp showed statistically significant increase in vacuolated epithelial cells and area percentage of mature collagen fibers, as well as statistically significant reduction in PCNA-positive cells and apparent reduction of epithelial thickness. On the other hand, the melatonin Gp displayed statistically significant increase in PCNA-positive cells, area percentage of immature collagen fibers, while significant decrease in No. of vacuolated epithelial cells and apparent increase of epithelial thickness. Discussion: Aging resulted in deteriorated regeneration, enhanced apoptosis, with reduced cellularity and vascularity. On the other hand, melatonin greatly improved cellular proliferation, reduced apoptosis, enhanced CT tissue regeneration and collagen production. As well as reduction in inflammatory cells.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

Awwad

2020

Egyptian Dental Journal

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“…Increased prevalence in maxillary denture fracture reported by Takamiya 5 and found significant difference from mandible. The reason for this finding is that mandibular dentures being thinnest in the middle area plus less surface area as compared to maxilla results in more breakage 5,20,21 .…”

Section: Discussionmentioning

confidence: 99%

Frequency and Causes of Fracture of Acrylic Resin Complete Dentures in Edentulous patients

Iftikhar¹,

Saleem²,

Awais³

et al. 2022

PJMHS

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Background: The rehabilitation of edentulous patients requires acrylic resin complete dentures to fulfil their functional and esthetic needs. Fractures of dentures are one of the commonest complaints around the world. Aim: To evaluate the frequency of acrylic complete denture fractures among edentulous patients and find out their association with certain variables. Methodology: A cross sectional observational study was carried out in Prosthodontic department of Lahore Medical and Dental College, Lahore from 26th March 2020 to 26th September 2021. A total of 58 completely edentulous patients reported with fractured acrylic dentures were selected. Patients were evaluated both intra and extra orally to find out the cause and site of fracture. Various parameters namely, denture age, fracture sites, gender were statistically evaluated to find out their relationship with denture fracture. Results: Results showed that male patients; 56.9% were presenting more with fractured dentures than female; 43.10%. In males the midline denture fractures were most commonly seen 45.5%, whereas in females’ fracture at premolar area was commonly observed 28.0% however no statistical dependance between fractured dentures sites and gender was found. Denture fractures were most prevalent in mandibular arch 50% as compared to maxillary 39.7%. Mid line fracture was the commonest site observed in both maxillary 30.4% and mandibular arches 31.0%. Insignificant association between fracture sites and dental arches was seen. Maximum denture fractures were recorded in first 2 years of denture fabrication 55.2%. The most frequent cause of denture fracture was accidental falling 34.5%. Conclusion: The frequency of complete denture fracture is more in mandible as compared to maxilla and the main reason is patients’ negligence. The study also showed midline fracture of dentures to be the most frequent site of denture fracture. Keywords: Acrylic dentures, Complete dentures, Edentulism, Edentulous, Prosthesis, Tooth loss,

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“…The lining mucosa of the oral cavity is responsible for protection of the sensitive deeper tissues from forces of mastication and other potentially harmful insults. Alterations occurring within oral mucosa with aging, are reflected on the structure and function of senile tissues, minimizing their resistance to various insults [35] . Skin structural alterations also become apparent with senility, as many histological, biochemical and functional alterations occur within senile skin [36] .…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Effect of Melatonin Versus Vitamin C on Aged Labial Tissues in Albino Rats

Awwad

Hamid

2020

Egyptian Journal of Histology

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Background: Structural changes occur with aging, associated with fibrosis and inflammation in body tissues. Aging of oral mucosa causes alterations in oral epithelium and sub-epithelial tissues, due to reduction in certain growth factors, endogenous anti-oxidant enzymes, or both. Aim: to assess anti-aging potential of melatonin & vitamin C on albino rats' lips. Materials and Methods: 28 male albino rats were used, divided into: Group I: 7 rats aged 6 months (18 years in humans), Group II: 21 rats aged 24 months (72 years in humans), were equally subdivided into 3 subgroups 7 rats each as follows: Subgroup IIA: positive control for other subgroups; Subgroup IIB: received melatonin via gastric gavage (10mg/kg/day) for six consecutive weeks; Subgroup IIC: received vitamin C via gastric gavage (2mg/ml/day) for six consecutive weeks. At the end of the experiment, rats were sacrificed by a high dose of anesthesia. The lips were excised. Specimens were processed for histological examination, stained by H&E, Masson's Trichrome& Anti-VEGF, examined by light microscope. Results: Subgroup IIA showed statistically significant increase in number of vacuolated epithelial cells, statistically significant reduction in VEGF positive cells, apparent decrease in epithelial thickness, statistically significant reduction in immature collagen fibers' percentage within connective tissue (CT). Subgroups IIB & IIC, showed significant reduction in number of vacuolated epithelial cells and significant increase in VEGF positive cells and area percentage of immature collagen fibers in CT. However, subgroup IIB's epithelial structure showed better image and subgroup IIC's CT structure presented better image. Conclusion: Aging showed structural changes in skin & mucous membrane sides of rat lips, observed within both epithelium and CT. Melatonin & vit. C exhibited efficiency in counteracting these effects. Melatonin presented superior effect on keratinocytes, vit. C showed superiority in repairing senile CT components.

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Gerodontology: effects of ageing on the oral mucosa

Cited by 11 publications

References 0 publications

Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

Modulatory Role of Melatonin on the Structure of Hard Palatal Mucosa of Aged Rats

Frequency and Causes of Fracture of Acrylic Resin Complete Dentures in Edentulous patients

A Comparative Study of the Effect of Melatonin Versus Vitamin C on Aged Labial Tissues in Albino Rats

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