Abstract:Purpose
The study aimed to generate a stepwise method to reduce the workload of full-scale
RB1
sequencing for germline mutation screening in retinoblastoma (RB) patients. The implication of germline mutation in tumor focality was also determined in this study.
Methods
A stepwise method was created on the basis of “hotspot” exons analyzed using data on germline
RB1
mutation in the
RB1
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