Germline Genetic Mutations in Adult Patients with Sarcoma: Insight into the Middle East Genetic Landscape
Ramiz Abu-Hijlih,
Baha Sharaf,
Samer Salah
et al.
Abstract:Data on germline mutations in soft tissue and bone sarcomas are scarce. We sought to identify the prevalence of germline mutations in adult sarcoma patients treated at a tertiary cancer center. Newly diagnosed patients were offered germline genetic testing via an 84-gene panel. The prevalence of pathogenic germline variants (PGVs) and their association with disease-, and patient- related factors are reported. A total of 87 patients were enrolled, the median age was 48 (19–78) years, and 47 (54%) were females. … Show more
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