Germinal Testicular Tumors in Childhood

Weißbach, L.; Altwein, Jens E.; Stiens, R

doi:10.1159/000463762

Cited by 72 publications

(8 citation statements)

References 34 publications

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“…In these patients, two nerves (L1) which showed no reactions were cut to ensure that the As 2% of the solitary initial metastases in patients with stage B disease are on the contralateral side below surgery was radical. In one patient with left testicular the aorta mesenterica inferior, bilateral RLND should be The preservation of ejaculation to achieve paternity is limited in patients undergoing secondary RLND, because discussed [14]. The present results showed that antegrade ejaculation was preserved even after bilateral only a few patients will regain complete spermatogenesis after intensive chemotherapy.…”

mentioning

confidence: 59%

An intra‐operative seminal and prostate emission test as a control for nerve‐sparing procedures in primary and secondary retroperitoneal lymphadenectomy

Recker

Goepel

Otto

et al. 1996

British Journal of Urology

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A positive result in the seminal emission test predicted the preservation of antegrade ejaculation after surgery. The test is not necessary in patients with clinical stage A disease, but improves the chances of reducing morbidity. If the residual mass consists of necrosis or fibrosis, then electrostimulation during secondary RLND can help to identify important nerve structures when their origin is unknown initially. However, attempts to retain nerve function must not jeopardize the patient's survival. The test can be an option for clinical stage B disease with initial bilateral RLND, to identify and preserve emission-relevant nerves while the retroperitoneal space is removed radically. The test may also give additional information about the physiology of emission.

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mentioning

confidence: 59%

An intra‐operative seminal and prostate emission test as a control for nerve‐sparing procedures in primary and secondary retroperitoneal lymphadenectomy

Recker

Goepel

Otto

et al. 1996

British Journal of Urology

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“…Sonography can be helpful for detection of small tumors associated with a hydrocele. According to Weissbach et al [18] intrascrotal masses in children are germ-cell tumors in 71% of cases and nongerminal in 29%; the incidence was reported in 1169 children from their own experience and from the literature [18]. Considerations in the differential diagnosis of germ-cell tumors include benign stroma-cell tumors and Leydig-cell tumors.…”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

Testicular germ-cell tumors in childhood and adolescence

Haas¹,

Schmidt²

1995

World J Urol

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Testicular germ-cell tumors are relatively rare in childhood and adolescence, accounting for only 3.9% of all neoplasms. However, they have become a model for curable cancer. Furthermore, most of them have accurate serum markers [beta-human chorionic gonadotropin and alpha-fetoprotein], which provide in clinical stage I disease after semicastration a "wait and see" program. MAHO 82, 88, and 92 were cooperative studies on the treatment of testicular germ-cell tumors in childhood and adolescence. Between 1982 and 1993, 137 patients were registered. In all, 76 patients suffered from yolk-sac tumors (YST); 30, from differentiated teratomas (TD); 29, from malignant teratomas of either intermediate (MTI), undifferentiated (MTU), or trophoblastic type (MTT); and 2, from seminomas. All patients received semicastration. Chemotherapy was given to 53 patients on the basis of disease stage and histology. Standard therapy consisted of four courses of vinblastine, bleomycin and cisplatin. However, if viable tumor was suspected after two courses, delayed laparotomy was performed (seven patients). If there was then complete tumor regression, standard therapy was continued (four patients). If there was an incomplete tumor response, the patients received as salvage therapy three courses of etoposide (VP-16), ifosfamide, and cisplatin (three patients). Among the patients with YST, 73 had stage I disease and 3, higher-stage disease; 1 of these died due to tumor progression. In all, 56 patients were followed according to the "wait and see" policy; 9 of these needed a delayed standard chemotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…From reports given in the literature (20,22), c1inical staging alone was insufficient, since about 30% of stage I patients were proven to be stage 11 by staging laparotomy. Our results cannot add new information to this question because astaging laparotomy was performed in only 7113 cases.…”

Section: Stage I Yolk Sac Tumorsmentioning

confidence: 99%

“…To avoid a primary Iymphadenectomy with high risk for loss of ejaculation (22,23) The staging c1assification used was the Lugano staging (19). For stage I A-I C it is based on the findings obtained by semicastratio.…”

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confidence: 99%

Testicular Germ Cell Tumors

et al. 1995

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The MAHO studies 82, 88 and 92 were cooperative studies for the treatment of testicular germ cell tumors in childhood. Between 1992 and 1993 137 Patients were registered: 76 suffered from yolk sac tumors (YST), 30 from differentiated teratomas (TD), 29 from malignant teratomas of either intermediate (MTI), undifferentiated (MTU) or trophoblastic type (MTT) and 2 from seminoma. All patients received semicastratio. Chemotherapy was administered to 53 patients based on stage and histology. Standard therapy consisted of four courses of vinblastine, bleomycin and cisplatinum. However, if viable tumor was suspected after two courses delayed laparotomy was performed (7 patients). If there was then complete tumor regression, standard therapy was continued (4 pts). If there was incomplete tumor response, the patients received a salvage therapy with 3 courses of VP 16, ifosfamide and cisplatinum (3 pts). Results YST: 73 patients had stage I, 3 patients higher stages. 56 were followed according to "watch and wait" policy. 9 of these needed a delayed standard chemotherapy, one died. The disease free survival of all 76 patients is 98%. TD: 30 patients had stage I. The disease free survival is 100%. Malignant teratomas (MTI, MTU, MTT): 13 patients had stage I. 8 received adjuvant chemotherapy and 5 lymphadenectomy without chemotherapy. All patients survived disease free. 10 patients had stage II and received chemotherapy. All patients survived disease free. 6 patients had stage III. 3 died. Altogether 26 of 29 patients survived disease free. In summary, the probability of disease free survival of all 137 patients suffering from testicular germ cell tumors is 97% after a median observation time of 60 months.

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Germinal Testicular Tumors in Childhood

Cited by 72 publications

References 34 publications

An intra‐operative seminal and prostate emission test as a control for nerve‐sparing procedures in primary and secondary retroperitoneal lymphadenectomy

An intra‐operative seminal and prostate emission test as a control for nerve‐sparing procedures in primary and secondary retroperitoneal lymphadenectomy

Testicular germ-cell tumors in childhood and adolescence

Testicular Germ Cell Tumors

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