Germinal Centers and Antibody Production in Bone Marrow

Tew, John G.; Dilosa, Rose Marie; Burton, Gregory F.; Kosco, Marie H.; Kupp, Leo I.; Masuda, Arata; Szakal, Andras K.

doi:10.1111/j.1600-065x.1992.tb00633.x

Cited by 127 publications

(76 citation statements)

References 25 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3B). The presence of anti-Sm ASCs in BM and spleen suggests a splenic B cell response (31)(32)(33)(34)(35)(36), while the presence of anti-Sm ASCs in the MLN and LP suggests a peritoneal B-1 cell response (27)(28)(29)(30). To determine whether FO (transitional and mature) or MZ B cells are involved in this response, cells of each population were sorted and analyzed by ELISPOT.…”

Section: A Deficiency In Apoptotic Cell Clearance Results In Anti-sm mentioning

confidence: 99%

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells

Qian

Wang

Clarke

2004

The Journal of Immunology

View full text Add to dashboard Cite

Since apoptotic cell Ags are thought to be a source of self-Ag in systemic lupus erythematosus, we have examined the role of apoptotic cells in the regulation and activation of B cells specific for Sm, a ribonucleoprotein targeted in human and murine lupus. Using Ig-transgenic mice that have a high frequency of anti-Sm B cells, we find that apoptotic cell injection induces a transient splenic B cell response, while simultaneously causing extensive splenic and peritoneal anti-Sm B cell death. In contrast, mice deficient in the clearance of apoptotic cells develop a chronic anti-Sm response beginning at 1–2 mo of age. These mice have expanded marginal zone and B-1 B cell populations and anti-Sm B cells of both types are activated to form Ab-secreting cells. This activation appears to be Ag-specific, suggesting that activation is due to increased availability of apoptotic cell Ags. Since marginal zone and B-1 cells are positively selected, these data suggest a loss of ignorance rather than a loss of tolerance.

show abstract

Section: A Deficiency In Apoptotic Cell Clearance Results In Anti-sm mentioning

confidence: 99%

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells

Qian

Wang

Clarke

2004

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…This may indicate that different ligands drive germinal centre B cells into different differentiation pathways, namely either plasma cell or memory cell generation. That germinal centre B cells can indeed differentiate in either direction is supported by evidence from in vivo experiments (Coico et al, 1983;Tew et al, 1992).…”

Section: Introductionmentioning

confidence: 91%

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

et al. 1993

View full text Add to dashboard Cite

“…Binding to FDC is a prerequisite for GC B cells to survive. Cells that do not succeed in binding to FDC die rapidly by apoptosis (3)(4)(5). Besides the Ag-specific interaction, FDCs also provide a set of adhesion molecules and cytokine signals to facilitate the appropriate interaction with GC B cells (6).…”

Section: G Erminal Centers (Gc)mentioning

confidence: 99%

Functional Effects of TNF-α on a Human Follicular Dendritic Cell Line: Persistent NF-κB Activation and Sensitization for Fas-Mediated Apoptosis

Park

Lee

2003

The Journal of Immunology

View full text Add to dashboard Cite

Follicular dendritic cells (FDC) play crucial roles in germinal center (GC) formation and differentiation of GC B cells. FDC functions are influenced by cytokines produced in the GC. Among the GC cytokines, TNF is known to be essential for the formation and maintenance of the FDC network in the GC. We found that TNF is a mitogenic growth factor to an established FDC-like cell line, HK cells. Differing from most cell types which become desensitized to TNF action, HK cells exhibited persistent TNF signaling, as demonstrated by prolonged and biphasic NF-κB activation even after 3 days of TNF treatment. As a result, antiapoptotic genes including TNFR-associated factors 1 and 2, and cellular inhibitor of apoptosis proteins 1 and 2 were persistently induced by TNF, leading to the protection against TNF-mediated cell death. However, TNF pretreatment enhanced Fas-mediated apoptosis by up-regulating surface Fas expression in an NF-κB-dependent pathway. During the GC responses, proliferation followed by FDC death has not been documented. However, our in vitro results suggest that FDCs proliferate in response to TNF, and die by Fas-mediated apoptosis whose susceptibility is enhanced by TNF, representing a mode of action for TNF in the maintenance of FDC networks by regulating the survival or death of FDC.

show abstract

Germinal Centers and Antibody Production in Bone Marrow

Cited by 127 publications

References 25 publications

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

Functional Effects of TNF-α on a Human Follicular Dendritic Cell Line: Persistent NF-κB Activation and Sensitization for Fas-Mediated Apoptosis

Contact Info

Product

Resources

About