Germinal center derived malignant lymphoma in cystadenolymphoma

Abstract

Two cases of malignant non-Hodgkin's lymphoma arising in an Albrecht-Arzt-tumour are reported. In the first case a centroblastic-centrocytic lymphoma in a palatinal cystadenolymphoma of a 64-year-old female is described. In the other case a centroblastic lymphoma developed in an Albrecht-Arzt-tumor of the submandibular region in an 82-year-old man. The occurrence of a high-grade malignant lymphoma in cystadenolymphoma has not been reported in the literature so far.

T cell lymphoblastic lymphoma in parotidectomy for Warthin’s tumor: case report and review of the literature

“…However, according to Griesser et al there is no significant evidence that micro-environmental factors in WT facilitate the development of germinal center lymphomas [8]. In the case of Marioni et al the presence of two distinct parotid lesions-MALT lymphoma and WT-may be simply a coincidence [16].…”

“…The majority of non-NHLs involving WT were follicle-centre lymphomas (12/23 reported cases; 52,2%) [2, 4-8, 11, 12, 14, 15]. Two cases of diffuse large B cell lymphoma [8,19] and two cases of B-small lymphocytic lymphoma [10,18] have been reported. There are only two cases of Hodgkin's lymphoma [9,13], one case of large cell lymphoma [3], one case of mucosa associated lymphoid tissue (MALT) lymphoma [16], one case of mantle cell lymphoma [4] and one case of lymphoma which was not further classified [2].…”

“…Lymphomas associated with WT are extremely rare. A review of the English literature provided 23 cases of WT related to malignant lymphoma (Table 1) [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Considering only the cases with existing data, this association occurred in eighteen males (81,8%) and four females (18,2%), with a mean age of 67 years.…”

“…To date, there are 23 reported cases in the English literature of lymphomas associated with WT [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Most cases are B cell lymphomas-namely follicular lymphoma [2, 4-8, 11, 12, 14, 15], small lymphocytic lymphoma [10,18] and diffuse large B-cell lymphoma [8,19]-and are usually associated with generalized disease, which is either present at the time of diagnosis or develops subsequently. The co-existence of WT and T-cell lymphoma is extremely rare [17].…”

Lymphoid Lesions of the Head and Neck: A Model of Lymphocyte Homing and Lymphomagenesis

“…It can be a site of involvement by malignant lymphoma and, rarely, malignant lymphoma may present in a Warthin's tumor. The most common lymphoma in this site is follicular lymphoma (76,77). Hodgkin's lymphoma is occasionally seen (78).…”