Germinal Center Cell‐Derived Lymphomas of the Skin

Kerl, Helmut; Kresbach, H

doi:10.1111/j.1524-4725.1984.tb00901.x

Cited by 25 publications

(4 citation statements)

References 8 publications

(5 reference statements)

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“…cutaneous di¡use large B cell lymphomas of the leg. The speci¢c gene expression signatures found in FL and primary cutaneous di¡use large B cell lymphomas, not involving the leg, give further support for a GC origin of these entities, which was shown previously (Kerl and Kresbach, 1984;Gellrich et al, 2001) and may explain the overall favorable prognosis of these patients. A larger set of tumor samples may help to identify single or multiple genes, which will be of diagnostic, prognostic, and therapeutic value, and will intensify our understanding of the diverse biology of these tumors.…”

Section: Discussionsupporting

confidence: 63%

Gene Expression Profiles of Cutaneous B Cell Lymphoma

Storz

Rijn

Kim

et al. 2003

Journal of Investigative Dermatology

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We studied gene expression profiles of 17 cutaneous B cell lymphomas that were collected with 4-6 mm skin punch biopsies. We also included tissue from two cases of mycosis fungoides, three normal skin biopsies, and three tonsils to create a framework for further interpretation. A hierarchical cluster algorithm was applied for data analysis. Our results indicate that small amounts of skin tissue can be used successfully to perform microarray analysis and result in distinct gene expression patterns. Duplicate specimens clustered together demonstrating a reproducible technique. Within the cutaneous B cell lymphoma specimens two specific B cell differentiation stage signatures of germinal center B cells and plasma cells could be identified. Primary cutaneous follicular and primary cutaneous diffuse large B cell lymphomas had a germinal center B cell signature, whereas a subset of marginal zone lymphomas demonstrated a plasma cell signature. Primary and secondary follicular B cell lymphoma of the skin were closely related, despite previously reported genetic and phenotypic differences. In contrast primary and secondary cutaneous diffuse large B cell lymphoma were less related to each other. This pilot study allows a first glance into the complex and unique microenvironment of B cell lymphomas of the skin and provides a basis for future studies, which may lead to the identification of potential histologic and prognostic markers as well as therapeutic targets.

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Section: Discussionsupporting

confidence: 63%

Gene Expression Profiles of Cutaneous B Cell Lymphoma

Storz

Rijn

Kim

et al. 2003

Journal of Investigative Dermatology

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“…Differentiation of CLH from MZL using only hematoxylin and eosin‐stained sections remains difficult, however, and additional studies are usually employed in an attempt to demonstrate B‐cell predominance (40% of MZL cases have a B:T‐cell ratio of ≥ 3:1) 15 and a monoclonal B‐cell population. Primary cutaneous follicular center cell lymphoma, 23–26 especially when it demonstrates a follicular (multinodular) growth pattern, 26 can also closely mimic CLH.…”

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confidence: 99%

Heavy multinodular cutaneous lymphoid infiltrates: clinicopathologic features and B‐cell clonality

et al. 2002

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“…A lymphoma is considered to be "primary" to the skin if there is no extra-cutaneous disease at the time (and within the first 6 months) of its diagnosis (2,4,5). Primary cutaneous FCL has been reported in the European Organization for Research and Treatment of Cancer (EORTC) for Cutaneous Lymphomas (2) and in other studies as a distinct entity, which has a good prognosis and rarely disseminates to extracutaneous sites (4,6,7). But it has been argued, that the entity classified as cutaneous FCL in the EORTC is not the same as those described in other classifications (5,8).…”

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confidence: 99%